Bioinformatics

生物信息学

基本信息

批准号：
9071334
负责人：
KAREN E KNUDSEN
金额：
$ 12.31万
依托单位：
THOMAS JEFFERSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9071334
关键词：
Bioinformatics Bioinformatics Shared Resource Biomedical Research Biometry Cancer Center Cancer Patient Clinical Clinical Research Clinical Trials Collaborations Communities Community Hospitals Complement Computer software Computers Consultations Contracts Core Facility Data Data Analyses Databases Disasters Equipment Funding Generations Grant Health Insurance Portability and Accountability Act Individual Informatics Information Technology Instruction Malignant Neoplasms Mining Mission NCI Center for Cancer Research Operations Research Pathology Peer Review Privacy Publications Recovery Regulation Reporting Research Research Activity Research Infrastructure Research Personnel Research Project Grants Reservations Resource Informatics Resource Sharing Resources Security Services Specimen System Technology Tissue Banking Tissue Banks Translational Research United States National Institutes of Health Universities anticancer research biomedical informatics cancer genomics cohort common rule data management direct application human subject informatics shared resource interest interoperability member neoplasm registry operation programs repository software development tool tumor registry web site

项目摘要

PROJECT SUMMARY (See instructions): The Informatics Shared Resource (ISR) serves as a biomedical research informatics resource for KCC's basic, clinical, and translational investigators. This support includes infrastructure! provisioning, software development or acquisition, and consultative collaboration. ISR services are available directly to peer reviewed funded cancer investigators, or indirectly to other cancer center core facilities, thereby providing services to all program members. The ISR also provides informatics support for the clinical research activities of the Jefferson Kimmel Cancer Center Network of community hospitals. More specifically, the ISR supports cancer center research by developing and/or deploying: 1) Clinical trials applications to give clinical researchers the tools to manage clinical trials data, including mandated reporting. 2) Biospecimen repository applications to help tissue bank staff manage specimen accessioning and distribution, and provide investigators with an ordering mechanism and information characterizing specimens available for research. 3) Data warehousing and mining applications to provide cancer researchers with a research data mart that integrates clinical, biospecimen, cancer registry, clinical trials, and experimental data for cohort identification and hypothesis generation. 4) Infrastructure and applications for other KCC shared resources to facilitate access to their services. The ISR thus provides KCC investigators with ready access to integrated comprehensive information on clinical trials, cancer patients, and research specimens, as well as providing a single portal for requesting equipment and services from KCC shared resources. In all its activities, the ISR recognizes interoperability as crucial to the sharing of research data and resources to promote efficient cancer research, and utilizes standards articulated by the NCI and the biomedical informatics community. Software applications are hosted on servers with networked storage located at a commercial data center contracted by the University, providing professional data center security and disaster recovery services. The ISR employs best practices with regard to data privacy and security complying with the Common Rule, HIPAA, and state regulations.

项目摘要（请参阅说明）：信息学共享资源（ISR）是KCC基本，临床和翻译研究人员的生物医学研究信息学资源。此支持包括基础架构！提供，软件开发或获取以及协商合作。 ISR服务可直接用于同行评审的经过资助的癌症调查人员，或间接向其他癌症中心核心设施提供，从而为所有计划成员提供服务。 ISR还为杰斐逊·金梅尔癌症中心社区医院网络的临床研究活动提供信息学支持。更具体地说，ISR通过开发和/或部署来支持癌症中心的研究： 1）为临床研究人员提供临床试验应用程序，以管理临床试验数据，包括授权报告。 2）生物测量存储库应用程序，以帮助组织库员工管理标本登录和分发，并为调查人员提供订购机制和信息，以表征可用于研究的标本。 3）数据仓库和采矿应用，以为癌症研究人员提供一个研究数据MART，该研究MART整合了临床，生物环境，癌症注册中心，临床试验和实验数据，以进行队列鉴定和假设产生。 4）其他KCC共享资源的基础架构和应用程序，以促进访问其服务。因此，ISR为KCC调查人员提供了准备访问有关临床试验，癌症患者和研究标本的综合信息，并提供了单个门户网站，用于从KCC共享资源那里索取设备和服务。在所有活动中，ISR都认为互操作性对于共享研究数据和资源以促进有效的癌症研究至关重要，并利用了NCI和生物医学信息学界阐明的标准。软件应用程序托管在服务器上，该服务器的网络存储位于大学合同的商业数据中心，提供专业数据中心安全和灾难恢复服务。 ISR对符合共同规则，HIPAA和州法规的数据隐私和安全性采用了最佳实践。