Translational Research

转化研究

基本信息

批准号：
9071331
负责人：
KAREN E KNUDSEN
金额：
$ 24.62万
依托单位：
THOMAS JEFFERSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9071331
关键词：
Adopted Applications Grants Archives Basic Science Biological Assay Biological Markers Biological Preservation Blood Body Fluids Cancer Center Clinical Clinical Data Clinical Pathology Clinical Research DNA Data Databases Development Equipment Evaluation Excision Experimental Animal Model Faculty Funding Goals Growth Histocompatibility Testing Histology Human Image Analysis Improve Access In Situ Individual Information Systems Instruction Ischemia Laboratories Lasers Location London Malignant Neoplasms Microdissection Mission Molecular Analysis Online Systems Operative Surgical Procedures Paraffin Pathology Patients Preparation Principal Investigator Procedures Process Publications Quality Control RNA Research Research Personnel Resource Sharing Resources Services Slide Specimen Staining method Stains Surgical Pathology System Time Tissue Banking Tissue Banks Tissue Microarray Tissue Procurements Tissues Translational Research Tumor Bank Tumor Tissue University Hospitals Update base benefit sharing cell type human tissue improved innovation member neoplastic neurosurgery next generation sequencing novel marker patient subsets programs sample collection targeted treatment time interval tissue processing tissue resource trial design

项目摘要

PROJECT SUMMARY (See instructions): Since the inception of the Translational Research Shared Resource its mission has been to provide tissue processing, slide preparation, histochemical staining, and immunohistochemical staining for human neoplastic tissue and experimental animal model tissue being utilized by KCC researchers. This shared resource has also provided procurement, banking and distribution of human neoplastic tissue in order to facilitate translational research. The caBlG caTissue biospecimen management application has been used by tissue bankers since 2007 to enter clinical and pathogical specimen annotation, as well as track specimen storage and distribution. This biospecimen database integrates access to 7 campus specimen collections having about 440,000 specimens from 170,000 individuals. In addition, the Translational Research Shared Resource provides tissue microarrays construction service with paraffin archive material from the resource tumor/tissue bank. Laser microdissection of distinct cell and tissue types for molecular analysis can be performed on the resource's Laser Microdissection system. For all of the capabilities offered by the Translational Research Shared Resource, staff is available to provide technical support and pathology expertise to KCC investigators. Between 2008 and 2011 23 principal investigators from all programs of the KCC benefited from this shared resource.

项目摘要（请参阅说明）：自转化研究的成立以来，其使命是为人类肿瘤组织和KCC研究人员使用的人类肿瘤组织和实验动物模型组织提供组织加工，幻灯片制备，组织化学染色和免疫组织化学染色。该共享资源还提供了人类肿瘤组织的采购，银行和分配，以促进转化研究。自2007年以来，组织银行家已使用CABLG Catissue Biospecimen Management应用程序进入临床和病原标本注释，以及轨道标本的存储和分布。该Biospecimen数据库集成了对170,000个人的大约440,000个标本的7个校园标本收集的访问。此外，转化研究共享资源提供了组织微阵列建筑服务，并提供了来自资源肿瘤/组织库的石蜡档案材料。可以在资源的激光显微解剖系统上进行不同细胞和组织类型的激光显微解剖。对于所有功能由转化研究共享资源提供的，员工可以为KCC调查人员提供技术支持和病理专业知识。在2008年至2011年之间，来自KCC所有计划的所有计划的主要研究人员都从这种共享资源中受益。