Molecular Biology and Genetics Program

分子生物学和遗传学计划

基本信息

批准号：
9071324
负责人：
KAREN E KNUDSEN
金额：
$ 3.09万
依托单位：
THOMAS JEFFERSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9071324
关键词：
Biochemistry Biology Cancer Center Cancer Patient Cell Proliferation Cells Collaborations Diagnosis Faculty Gene Expression Regulation Gene Targeting Genes Genetic Programming Genetic Transcription Goals Grant Hematologic Neoplasms Immunity Influentials Institutes Journals Malignant Neoplasms Medical Research Molecular Molecular Biology Molecular Genetics Nature Normal Cell Oncogenes Paper Peer Review Peer Review Grants Postdoctoral Fellow Prevention therapy Process Publications Publishing Solid Neoplasm Testing Training Transcriptional Regulation Translating Translational Research Tumor Markers Universities base cancer diagnosis cancer prevention cell growth cost design gene discovery gene function graduate student improved interest meetings member mouse model neoplastic cell novel novel diagnostics novel therapeutic intervention personalized medicine prognostic programs targeted treatment tumor tumorigenesis

Biochemistry Biology Cancer Center Cancer Patient Cell Proliferation Cells Collaborations Diagnosis Faculty Gene Expression Regulation Gene Targeting Genes Genetic Programming Genetic Transcription Goals Grant Hematologic Neoplasms Immunity Influentials Institutes Journals Malignant Neoplasms Medical Research Molecular Molecular Biology Molecular Genetics Nature Normal Cell Oncogenes Paper Peer Review Peer Review Grants Postdoctoral Fellow Prevention therapy Process Publications Publishing Solid Neoplasm Testing Training Transcriptional Regulation Translating Translational Research Tumor Markers Universities base cancer diagnosis cancer prevention cell growth cost design gene discovery gene function graduate student improved interest meetings member mouse model neoplastic cell novel novel diagnostics novel therapeutic intervention personalized medicine prognostic programs targeted treatment tumor tumorigenesis

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项目摘要

Program 2, the Molecular Biology and Genetics of Cancer Program (MBG), integrates fundamental studies in the control of gene transcription and regulation with the genetic and molecular mechanisms underlying the most common types of solid tumors and hematological malignancies. An integral part of the KCC since 1991, this program focuses on gene discovery and gene function analyses in order to exploit the translational potential of these studies for cancer diagnosis, assessment, prevention and therapy. The long-term goal of this program is to discover information useful in designing "personalized therapies" for cancer patients. The Molecular Biology and Genetics of Cancer Program brings together 22 faculty members from 10 academic departments (including the Lankenau Institute for Medical Research and the Department of Biochemistry and Molecular Biology of Drexel University) who are supported by NCI ($3.25 million total costs) and other peer-reviewed grants ($7.80 million total costs). Many members of this program have made important discoveries that have been translated into improved cancer diagnosis and assessment, and into novel therapeutic approaches. In the last five years, program members have continued to interact productively, publishing approximately 100 papers/year in some of the best known and more influential journals such as Nature, Mol.Cell, J.Clin.Invest., Immunity, PNAS. Of papers published since 2007, 21.0% have been the result of intra-programmatic collaborations and 31.3% the result of inter-programmatic collaborations. The program has 15-20 graduate students and more than 80 postdoctoral fellows. Their training and the interactions, both intra- and inter-programmatic, among all members are supported by monthly meetings that enhance the program's translational focus.

计划2，《癌症计划的分子生物学和遗传学》（MBG），整合了基础研究用遗传和分子机制控制基因转录和调节实体瘤和血液学恶性肿瘤的最常见类型。自1991年以来，KCC不可或缺的一部分，该程序的重点是基因发现和基因功能分析，以利用翻译这些研究的癌症诊断，评估，预防和治疗的潜力。长期目标该计划是为了发现用于设计癌症患者“个性化疗法”的信息。这分子生物学和癌症计划的遗传学汇集了来自10个学术的22名教职员工部门（包括兰卡纳医学研究所和生物化学系 Drexel University的Molecular Biologular Biologuly）得到了NCI的支持（总计325万美元）和其他同行评审赠款（总成本为780万美元）。该计划的许多成员已经发现了重要的发现已转化为改善癌症的诊断和评估，并将其转化为新型治疗方法。在过去的五年中，计划成员继续有效地互动，出版在一些最著名和更具影响力的期刊（例如自然）中，大约有100篇论文 Mol.Cell，J.Clin.Invest。，免疫，PNAS。自2007年以来发表的论文中，有21.0％的结果是策略内协作，31.3％是程序间协作的结果。该程序有15-20名研究生和80多个博士后研究员。他们的训练和互动，都在所有成员中，在所有成员中，每月会议都支持程序的翻译重点。