University of Hawaii Cancer Center CCSG

夏威夷大学癌症中心 CCSG

• 批准号: 10837568
• 负责人: Naoto T Ueno
• 金额: $ 219.1万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10837568
• 关键词: Address; Analytical Biochemistry; Appointment; Authorization documentation; Bioinformatics; Biometry; Budgets; Cancer Biology; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Etiology; Cancer Research Project; Catchment Area; Characteristics; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Health Education; Community Networks; Community Outreach; Community Trial; Education; Environment; Ethnic Origin; Evaluation; Faculty; Faculty Recruitment; Financial Support; Foundations; Funding; Genomics; Goals; Guam; Hawaii; Health system; Infrastructure; Intervention; Intervention Trial; Investigation; Investments; Malignant Neoplasms; Medical; Mission; Native Hawaiian; Natural Resources; Network-based; Patient Care; Peer Review; Policies; Population; Population Sciences; Prevention trial; Process; Public Health; Public Health Practice; Publications; Research; Resource Sharing; Risk Assessment; Science; Statutes and Laws; Strategic Planning; Translating; Universities; anticancer research; authority; cancer clinical trial; cancer health disparity; cancer prevention; cancer risk; cancer therapy; community engagement; drug discovery; ethnic diversity; health care delivery; inter-institutional; member; metabolomics; novel; nutrition; operation; population based; programs; recruit; square foot

ABSTRACT The mission of the University of Hawai‘i Cancer Center (UHCC) is to reduce the burden of cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural and environmental characteristics of Hawai‘i and the Pacific. To accomplish this mission, UHCC is organized into two cancer research programs: Population Sciences in the Pacific (PSP) and Cancer Biology (CB). Programs are each organized with two components spanning the study of basic mechanism and etiologies of cancer to addressing targets and interventions in order to translate discovery to the population it serves. Within its programs, UHCC has a strong foundation of cancer research with over $15 million in peer-reviewed funding, 68% of which is from the NCI. PSP has 24 full members and CB has 18 full members who are highly collaborative as evidenced by a high percentage of intra- and inter-programmatic, and inter-institutional, research collaborations and publications. To facilitate successful attainment of research goals, UHCC supports five shared resources: Biostatistics, Genomics and Bioinformatics, Analytical Biochemistry, Nutrition Support, and Metabolomics. UHCC serves a unique ethnically diverse catchment area in Hawai‘i and the Pacific and a unique environment rich in natural resources. This drives UHCC’s focus on ethnic diversity and cancer and research and community engagement directed toward addressing significant cancer health disparities among specific populations, including Native Hawaiians. Research programs, community education, public health and clinical trial interventions are targeted toward cancers of importance in the catchment area and basic investigations include evaluation of compounds from the environment for drug discovery research. A unique, community-network based clinical research enterprise has been established through which UHCC provides access to cancer clinical trials for over 70% of the Hawai‘i population; this is supported in part by a UHCC-led affiliation of three competing health systems as a cooperative venture supporting UHCC. Cancer prevention activities across the Pacific, in collaboration with the University of Guam and others, have had major impact on cancer control and have led to the formation of the UHCC-led Trans-Pacific Partnership for Cancer Prevention. The importance of UHCC in the region is exemplified by its significant impact on cancer control legislation and State cancer policy. The University of Hawai‘i (UH) has made significant investments in UHCC. With the recruitment new Director, UH reaffirmed the Director’s direct authority over faculty appointments and affairs, Center budget and operations, and space allocation in the 187,000 sq. ft. Cancer Center building. The University, Governor and State have provided increased financial support for operations and authorized numerous faculty recruitments to strengthen existing programs and embark on new initiatives informed through the UHCC strategic planning process in support of its mission to reduce the burden of cancer.

抽象的 夏威夷大学癌症中心 (UHCC) 的使命是通过以下方式减轻癌症负担： 研究、教育、患者护理和社区外展，重点关注独特的种族、文化和 为了完成这一使命，UHCC 被组织为夏威夷和太平洋地区的环境特征。 两个癌症研究项目：太平洋人口科学（PSP）和癌症生物学（CB）。 每个项目都由两个组成部分组成，涵盖基本机制和病因学的研究 癌症的目标和干预措施，以便将发现转化为它所服务的人群。 UHCC 的项目拥有坚实的癌症研究基础，拥有超过 1500 万美元的同行评审资金， 其中68%来自NCI，PSP有24名正式会员，CB有18名正式会员，都是高度的。 合作性，高比例的项目内、项目间以及机构间研究就证明了这一点 为了促进研究目标的成功实现，UHCC 支持五个项目。 共享资源：生物统计学、基因组学和生物信息学、分析生物化学、营养学 支持和代谢组学 UHCC 为夏威夷和美国独特的种族多元化集水区提供服务。 太平洋和自然资源丰富的独特环境推动了 UHCC 对种族多样性和文化的关注。 癌症与研究以及社区参与旨在解决重大癌症健康问题 特定人群之间的差异，包括夏威夷原住民的研究计划、社区教育、 公共卫生和临床试验干预措施针对流域内的重要癌症 基础研究包括评估环境中的化合物以进行药物发现研究。 独特的、基于社区网络的临床研究企业已经建立，UHCC 通过该企业 为超过 70% 的夏威夷人口提供癌症临床试验的机会，这在一定程度上得到了 由 UHCC 领导的三个相互竞争的卫生系统作为支持 UHCC 癌症的合作企业。 与关岛大学和其他机构合作，在整个太平洋地区开展的预防活动取得了重大成果 对癌症控制产生影响，并促成了由 UHCC 领导的跨太平洋癌症伙伴关系的形成 预防。UHCC 在该地区的重要性体现在其对癌症控制的重大影响。 夏威夷大学 (UH) 对 UHCC 进行了大量投资。 通过招聘新主任，呃重申了主任对教师任命和任命的直接权力 事务、中心预算和运营以及 187,000 平方英尺癌症中心大楼的空间分配。 大学、州长和州为运营提供了更多的财政支持，并授权 大量招聘教师以加强现有项目并开展新举措 UHCC 战略规划流程支持其减轻癌症负担的使命。

项目成果

Analysis and Performance Assessment of the Whole Genome Bisulfite Sequencing Data Workflow: Currently Available Tools and a Practical Guide to Advance DNA Methylation Studies.

• DOI: 10.1002/smtd.202101251
• 发表时间: 2022-03
• 期刊: Small methods
• 影响因子: 12.4
• 作者: Gong T;Borgard H;Zhang Z;Chen S;Gao Z;Deng Y
• 通讯作者: Deng Y

cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue.

• DOI: 10.1371/journal.pone.0030477
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Loo LW;Cheng I;Tiirikainen M;Lum-Jones A;Seifried A;Dunklee LM;Church JM;Gryfe R;Weisenberger DJ;Haile RW;Gallinger S;Duggan DJ;Thibodeau SN;Casey G;Le Marchand L
• 通讯作者: Le Marchand L

Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis.

• DOI: 10.1016/j.ebiom.2016.03.023
• 发表时间: 2016-05
• 期刊: EBioMedicine
• 影响因子: 11.1
• 作者: Ching T;Peplowska K;Huang S;Zhu X;Shen Y;Molnar J;Yu H;Tiirikainen M;Fogelgren B;Fan R;Garmire LX
• 通讯作者: Garmire LX

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.

• DOI: 10.1186/s12916-022-02702-9
• 发表时间: 2023-01-04
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Papadimitriou, Nikos;Bull, Caroline J.;Jenab, Mazda;Hughes, David J.;Bell, Joshua A.;Sanderson, Eleanor;Timpson, Nicholas J.;Smith, George Davey;Albanes, Demetrius;Campbell, Peter T.;Kury, Sebastien;Le Marchand, Loic;Ulrich, Cornelia M.;Visvanathan, Kala;Figueiredo, Jane C.;Newcomb, Polly A.;Pai, Rish K.;Peters, Ulrike;Tsilidis, Kostas K.;Boer, Jolanda M. A.;Vincent, Emma E.;Mariosa, Daniela;Gunter, Marc J.;Richardson, Tom G.;Murphy, Neil
• 通讯作者: Murphy, Neil

Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls.

• DOI: 10.1158/1940-6207.capr-13-0037
• 发表时间: 2013-08
• 期刊: Cancer prevention research (Philadelphia, Pa.)
• 作者: Terry KL;Karageorgi S;Shvetsov YB;Merritt MA;Lurie G;Thompson PJ;Carney ME;Weber RP;Akushevich L;Lo-Ciganic WH;Cushing-Haugen K;Sieh W;Moysich K;Doherty JA;Nagle CM;Berchuck A;Pearce CL;Pike M;Ness RB;Webb PM;Australian Cancer Study (Ovarian Cancer);Australian Ovarian Cancer Study Group;Rossing MA;Schildkraut J;Risch H;Goodman MT;Ovarian Cancer Association Consortium
• 通讯作者: Ovarian Cancer Association Consortium