University of Hawaii Cancer Center CCSG

夏威夷大学癌症中心 CCSG

• 批准号: 10837568
• 负责人: Naoto T Ueno
• 金额: $ 219.1万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10837568
• 关键词: Address; Analytical Biochemistry; Appointment; Authorization documentation; Bioinformatics; Biometry; Budgets; Cancer Biology; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Etiology; Cancer Research Project; Catchment Area; Characteristics; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Health Education; Community Networks; Community Outreach; Community Trial; Education; Environment; Ethnic Origin; Evaluation; Faculty; Faculty Recruitment; Financial Support; Foundations; Funding; Genomics; Goals; Guam; Hawaii; Health system; Infrastructure; Intervention; Intervention Trial; Investigation; Investments; Malignant Neoplasms; Medical; Mission; Native Hawaiian; Natural Resources; Network-based; Patient Care; Peer Review; Policies; Population; Population Sciences; Prevention trial; Process; Public Health; Public Health Practice; Publications; Research; Resource Sharing; Risk Assessment; Science; Statutes and Laws; Strategic Planning; Translating; Universities; anticancer research; authority; cancer clinical trial; cancer health disparity; cancer prevention; cancer risk; cancer therapy; community engagement; drug discovery; ethnic diversity; health care delivery; inter-institutional; member; metabolomics; novel; nutrition; operation; population based; programs; recruit; square foot

ABSTRACT The mission of the University of Hawai‘i Cancer Center (UHCC) is to reduce the burden of cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural and environmental characteristics of Hawai‘i and the Pacific. To accomplish this mission, UHCC is organized into two cancer research programs: Population Sciences in the Pacific (PSP) and Cancer Biology (CB). Programs are each organized with two components spanning the study of basic mechanism and etiologies of cancer to addressing targets and interventions in order to translate discovery to the population it serves. Within its programs, UHCC has a strong foundation of cancer research with over $15 million in peer-reviewed funding, 68% of which is from the NCI. PSP has 24 full members and CB has 18 full members who are highly collaborative as evidenced by a high percentage of intra- and inter-programmatic, and inter-institutional, research collaborations and publications. To facilitate successful attainment of research goals, UHCC supports five shared resources: Biostatistics, Genomics and Bioinformatics, Analytical Biochemistry, Nutrition Support, and Metabolomics. UHCC serves a unique ethnically diverse catchment area in Hawai‘i and the Pacific and a unique environment rich in natural resources. This drives UHCC’s focus on ethnic diversity and cancer and research and community engagement directed toward addressing significant cancer health disparities among specific populations, including Native Hawaiians. Research programs, community education, public health and clinical trial interventions are targeted toward cancers of importance in the catchment area and basic investigations include evaluation of compounds from the environment for drug discovery research. A unique, community-network based clinical research enterprise has been established through which UHCC provides access to cancer clinical trials for over 70% of the Hawai‘i population; this is supported in part by a UHCC-led affiliation of three competing health systems as a cooperative venture supporting UHCC. Cancer prevention activities across the Pacific, in collaboration with the University of Guam and others, have had major impact on cancer control and have led to the formation of the UHCC-led Trans-Pacific Partnership for Cancer Prevention. The importance of UHCC in the region is exemplified by its significant impact on cancer control legislation and State cancer policy. The University of Hawai‘i (UH) has made significant investments in UHCC. With the recruitment new Director, UH reaffirmed the Director’s direct authority over faculty appointments and affairs, Center budget and operations, and space allocation in the 187,000 sq. ft. Cancer Center building. The University, Governor and State have provided increased financial support for operations and authorized numerous faculty recruitments to strengthen existing programs and embark on new initiatives informed through the UHCC strategic planning process in support of its mission to reduce the burden of cancer.

抽象的 夏威夷大学癌症中心（UHCC）的任务是通过 研究，教育，患者护理和社区宣传，重点是独特的种族，文化和 夏威夷和太平洋的环境特征。为了完成这项任务，UHCC被组织成 两个癌症研究计划：太平洋（PSP）和癌症生物学（CB）的人口科学。 每个程序都有两个组成部分，涵盖了基本机制和病因的研究 为了解决目标和干预措施的癌症，以将发现转化为所服务的人群。之内 UHCC的计划是癌症研究的坚实基础，并拥有超过1500万美元的同行评审资金， 其中68％来自NCI。 PSP有24个正式成员，CB有18个正式成员 合作的是，很大比例的机构间和机构间研究 合作和出版物。为了促进成功实现研究目标，UHCC支持五个 共享资源：生物统计学，基因组学和生物信息学，分析生物化学，营养 支持和代谢组学。 UHCC在夏威夷为独特的种族多元化集水区服务 太平洋和独特的自然资源环境。这促使UHCC专注于种族多样性和 癌症，研究和社区参与旨在解决重大癌症健康 包括夏威夷人在内的特定人群之间的差异。研究计划，社区教育， 公共卫生和临床试验干预措施针对集水区重要性的癌症 基本研究包括评估来自药物发现研究环境的化合物。一个 建立了基于社区网络的独特，基于社区网络的临床研究企业。 为超过70％的夏威夷人口提供了癌症临床试验的机会；这部分由 UHCC领导的三个竞争卫生系统的分支机构，作为支持UHCC的合作风险。癌症 整个太平洋的预防活动，与关岛大学和其他人合作，都有很重要的 对癌症控制的影响，并导致建立了UHCC领导的癌症的跨太平洋伙伴关系 预防。 UHCC在该地区的重要性是用对癌症控制的重大影响来体现的 立法和州癌症政策。夏威夷大学（UH）在UHCC上进行了大量投资。 在招聘新任董事的情况下，UH重申了董事对任命的直接授权和 在187,000平方英尺的癌症中心大楼中的事务，中心预算和运营以及空间分配。这 大学，州长和州已为运营提供了更多的财政支持并授权 众多教师招聘以加强现有计划并着手开展新的计划 UHCC的战略规划过程支持其减少癌症燃烧的使命。

项目成果

Obesity and non-Hodgkin lymphoma survival in an ethnically diverse population: the Multiethnic Cohort study.

• DOI: 10.1007/s10552-014-0447-6
• 发表时间: 2014-11
• 期刊: CANCER CAUSES & CONTROL
• 影响因子: 2.3
• 作者: Leo, Qi Jie Nicholas;Ollberding, Nicholas J.;Wilkens, Lynne R.;Kolonel, Laurence N.;Henderson, Brian E.;Le Marchand, Loic;Maskarinec, Gertraud
• 通讯作者: Maskarinec, Gertraud

Maintenance Outcomes of the Children's Healthy Living Program on Overweight, Obesity, and Acanthosis Nigricans Among Young Children in the US-Affiliated Pacific Region: A Randomized Clinical Trial.

• DOI: 10.1001/jamanetworkopen.2022.14802
• 发表时间: 2022-06-01
• 期刊: JAMA network open
• 影响因子: 13.8

Associations of Subtype and Isomeric Plasma Carotenoids with Prostate Cancer Risk in Low-Income African and European Americans.

• DOI: 10.1158/1055-9965.epi-20-1785
• 发表时间: 2021-10
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Lee SA;Cai Q;Franke AA;Steinwandel M;Wu J;Wen W;Zheng W;Blot WJ;Shu XO
• 通讯作者: Shu XO

Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study.

• DOI: 10.1158/1055-9965.epi-14-0129
• 发表时间: 2014-11
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Park SL;Caberto CP;Lin Y;Goodloe RJ;Dumitrescu L;Love SA;Matise TC;Hindorff LA;Fowke JH;Schumacher FR;Beebe-Dimmer J;Chen C;Hou L;Thomas F;Deelman E;Han Y;Peters U;North KE;Heiss G;Crawford DC;Haiman CA;Wilkens LR;Bush WS;Kooperberg C;Cheng I;Le Marchand L
• 通讯作者: Le Marchand L

Vitamin D deficiency and insufficiency in Hawaii: Levels and sources of serum vitamin D in older adults.

• DOI: 10.1002/ajhb.23636
• 发表时间: 2022-03
• 期刊: American journal of human biology : the official journal of the Human Biology Council
• 作者: Oshiro CE;Hillier TA;Edmonds G;Peterson M;Hill PL;Hampson S
• 通讯作者: Hampson S