CORE--TUMOR BANK

核心——肿瘤库

• 批准号: 7142525
• 负责人: Robert C Young
• 金额: $ 3.86万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-10 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7142525
• 关键词: biomedical facility; cancer registry /resource; sample collection; tissue /cell preparation; tissue resource /registry

The Tumor Bank Facility (TBF) is a centralized resource for Fox Chase Cancer Center (FCCC) designated as the source of normal and tumor tissues for cancer research. The TBF is responsible for collecting, banking, and distributing normal and tumor specimens (fresh, frozen, or paraffin-embedded) accrued from consented patients treated surgically at FCCC. Accrual has increased 50% since the year of our last review (500 in 1999 versus 751 specimens in 2003). Usage of frozen samples has stabilized around 600 samples a year, peaking at 848 in 2002 (range during the last four years: 569-848 samples per year). The annual usage of paraffin sections of human tissues has stabilized between 2,000-4,000, whereas cut paraffin tissue microarray (TMA) sections grew steadily to 150 in 2003 and 2004 shows continued growth. In addition, the TBF continues to provide comprehensive pathology support, both at the technical and interpretative levels for FCCC investigators. Since our last review, the following new policies and services have been implemented: 1) a new Prioritization Subcommittee has been established, 2) we have increased the number of accrued tissues and their respective aliquots, 3) we introduced TMAs and extraction of nucleic acids from normal and neoplastic tissues to minimize depletion of our banked specimens. The introduction of TMAs has been very successful and has helped to reduce depletion of valuable tissues. A total of 35 TMAs are now available (total 1,891 tissue cores). We have distributed 40 TMA sections in 2002 and 149 sections in 2003. Similarly, we have started extracting and distributing nucleic acids to three investigators (total 73 samples in 2003. 4) A new Web-based data entry-system and database has been created. The TBF works closely with the Population Studies Facility to ensure that critical clinical information is linked to each of our de-identified tissue specimens. All our donors have been consented following NIH guidelines. The Facility follows the established guidelines of quality control (QC) and tissues are distributed only to IRB-approved projects. Furthermore, all operations, prioritization and distribution activities are overseen by the Tumor Bank and Biosample Repository Advisory Committee. This Facility is utilized by 24 peer-reviewed investigators from seven different Programs in all three Divisions. Seventy-seven percent (77%) of its use is by investigators with peer-reviewed funding.

肿瘤银行设施（TBF）是Fox Chase Cancer Center（FCCC）的集中资源 被指定为用于癌症研究的正常组织和肿瘤组织的来源。 TBF负责收集，银行业和分发正常和肿瘤标本（新鲜，冷冻或石蜡填充），该标本是在FCCC外科手术治疗的同意患者中得到的。自上次审查年以来，应计增长50％（1999年为500，而2003年的751个标本）。冷冻样品的使用每年稳定在600个样品中，2002年达到848（范围为过去四年：每年569-848个样品）。人类组织的石蜡切片的年度使用稳定在2,000-4,000之间，而切断的石蜡组织微阵列（TMA）切片在2003年和2004年稳定增长到150，显示出持续的增长。此外，在FCCC研究人员的技术和解释水平上，TBF继续提供全面的病理支持。自上次审查以来，已经实施了以下新的政策和服务：1）建立了新的优先级小组委员会，2）我们增加了应计组织及其各自的等分试样的数量，3）我们引入了TMAS和从正常和肿瘤组织中提取核酸的核酸，以最大程度地减少银行塑料的消耗。 TMA的引入非常成功，并有助于减少有价值的组织的消耗。现在共有35个TMA（总共1,891个组织核）。我们在2002年分配了40个TMA部分，并在2003年分发了149个部分。同样，我们已经开始向三个研究者提取和分发核酸（2003年总共73个样本。4），创建了一个新的基于Web的数据输入系统和数据库。 TBF与人口研究机构紧密合作，以确保关键的临床信息与我们的每个识别组织标本有关。我们所有的捐助者均遵循NIH指南。该设施遵循既定的质量控制指南（QC），组织仅分配给IRB批准的项目。此外，肿瘤库和生物样品存储库咨询委员会监督所有操作，优先级和分配活动。该设施由24个同行评审使用 来自所有三个部门的七个不同计划的调查人员。 77％ （77％）的使用是通过同行评审资金进行的调查员。