Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease

组织类器官作为宿主生理学和疾病病理生理学的模型

• 批准号: 9914441
• 负责人: Thale Cross Jarvis
• 金额: $ 1.3万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9914441
• 关键词: Affect; Area; Biomedical Research; British Columbia; Canada; Cell model; Clinical Trials; Collaborations; Communities; Development; Diagnosis; Disease; Dissection; Educational workshop; Engineering; Environmental Exposure; Explosion; Fertilization; Functional disorder; Health; Human; Human Biology; Intervention; Knowledge; Learning; Malignant Neoplasms; Methodology; Methods; Modeling; Molecular; Organ; Organoids; Outcome; Participant; Pathway interactions; Patients; Pharmaceutical Preparations; Physiology; Population; Property; Public Health; Regenerative Medicine; Reproduction; Research; Research Personnel; Scientist; System; Techniques; Technology; Therapeutic; Tissues; Touch sensation; Toxic effect; Translating; Vision; Work; body system; clinical practice; design; disease diagnosis; innovation; innovative technologies; novel; novel diagnostics; novel therapeutics; posters; precision medicine; programs; screening; symposium; therapeutic development; tool

ABSTRACT Support is requested for a Keystone Symposia conference entitled Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease, organized by Drs. Thaddeus S. Stappenbeck and Linda G. Griffith. The conference will be held in Vancouver, British Columbia Canada from January 19-23, 2020. Tissue organoids are becoming an increasingly sophisticated experimental system that is of importance in investigative work on nearly every organ system. There has been a recent explosion of techniques and platforms that enable dissection of fundamental questions, modeling cellular alterations in disease states and screening of compounds and molecules to discover new pathways. Fundamental work into organoid properties has developed the potential of organoids to become new methods for diagnosis, therapeutic selection and even to serve as regenerative medicine therapeutics themselves. This conference will bring together experts in organoids from various tissues and will create valuable cross-fertilization of ideas and approaches that will benefit many fields. A major gap is that this technology is being siloed in areas of specific tissues and molecular pathways. A general conference that cuts across all organs and major utilities will be of high value and will encourage groups to share ideas across organ systems. The conference program will also include engineering approaches that will highlight novel developments in organoid technology. As a result of this conference, it is anticipated that participants will have a much better understanding of the capabilities of organoid systems and see new avenues for exploration. This conference is designed to emphasize synthesis over reductionism. An additional aim of this conference is to help investigators make the connection to develop new diagnostic and therapeutic tools using organoids.

抽象的 请求支持题为“组织类器官作为宿主模型”的 Keystone 研讨会 疾病的生理学和病理生理学，由博士组织。撒迪厄斯·S·斯塔彭贝克 (Thaddeus S. Stappenbeck) 和琳达·G. 格里菲斯.会议将于2020年1月19日至23日在加拿大不列颠哥伦比亚省温哥华举行。 组织类器官正在成为一个日益复杂的实验系统，在以下方面具有重要意义： 几乎每个器官系统的调查工作。最近出现了技术和技术的爆炸式增长 能够剖析基本问题、对疾病状态下的细胞变化进行建模的平台 筛选化合物和分子以发现新途径。类器官特性的基础工作 开发了类器官成为诊断、治疗选择和治疗新方法的潜力 甚至可以用作再生医学疗法本身。本次会议将汇聚各领域专家 来自不同组织的类器官，将创造有价值的思想和方法的交叉受精 惠及诸多领域。一个主要差距是这项技术被孤立在特定组织和区域 分子途径。跨越所有机关和主要公用事业的大会将具有很高的价值 并将鼓励团体跨器官系统分享想法。会议议程还将包括 工程方法将突出类器官技术的新发展。结果是 会议上，预计与会者将对 类器官系统并寻找新的探索途径。本次会议旨在强调综合 过度还原论。这次会议的另一个目的是帮助研究人员建立联系以发展 使用类器官的新诊断和治疗工具。