Northwestern University O'Brien Kidney National Resource Center

西北大学奥布莱恩肾脏国家资源中心

• 批准号: 10754080
• 负责人: Alfred L. George
• 金额: $ 99.21万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754080
• 关键词: Affect; American; Area; Biological Products; Biomedical Engineering; Biosensor; Budgets; California; Career Choice; Cells; Cessation of life; Chemistry; Communicable Diseases; Communication; Communities; Coupling; Dedications; Development; Diagnostic; Discipline; Disease; Education; Educational workshop; Emerging Technologies; Ensure; Event; Exposure to; Goals; High School Student; Home; Homing; Human; Image; In Vitro; Incidence; Incubators; Individual; Internships; Investigation; Ions; Kidney; Kidney Diseases; Kidney Failure; Label; Mass Spectrum Analysis; Medicare; Medicine; Mentors; Mentorship; Methods; Mission; Molecular; Monitor; Nanotechnology; Oncology; Organ; Pathogenesis; Patient Care; Persons; Pharmaceutical Preparations; Phenotype; Physiologic Monitoring; Political Factor; Proteins; Proteomics; RNA; Reagent; Renal function; Research; Research Personnel; Resource Development; Resources; Risk; Science; Scientist; Services; Skin; Structure; Students; Talents; Technology; Therapeutic; Time; Tissue imaging; Tissues; United States; Universities; Vaccines; Vision; bioelectronics; biomedical resource; cardiovascular risk factor; care costs; cell type; comorbidity; cost; design; functional genomics; gene function; gene therapy; high school program; in vivo; innovation; intercalation; kidney cell; minority communities; nanocarrier; nanoparticle; nanoscale; new technology; new therapeutic target; novel strategies; novel therapeutics; operation; physical science; programs; protein function; research and development; screening; small molecule; social factors; success; theories; therapeutic development; therapeutic target; tool

SUMMARY – NU-NRC OVERALL Kidney diseases affect 37 million Americans, placing them at major risk for cardiovascular events, other co- morbidities, and death. While there have been exciting recent advances in our field, to impact these staggering numbers, it is critical to identify new therapeutic targets, expand our understanding of disease pathogenesis and develop new methods to target specific cell types in the kidney. To do this, we must push disciplinary boundaries, build new discovery platforms and partner with orthogonal disciplines. A major unmet challenge in kidney research is the dearth of technologies and platforms that can incorporate the complexity and diversity of kidney structure, cellular phenotypes and function in their design and execution. The proposed Northwestern University National Resource Center (NU-NRC) will meet this challenge by leveraging innovations in the physical sciences to provide unique tools, reagents, and platforms to kidney researchers. By design, these resources take advantage of tissue and cellular diversity, making them powerful technologies for discovery- based kidney research and therapeutic development. The overarching theme of the NU-NRC is to adapt powerful physical sciences theory, tools, platforms, and approaches to advance kidney investigation in a Physical Sciences-Kidney Resource Center. The major goals of the Center are to A) harness physical science advances to provide new approaches to solve unmet challenges in kidney research and discovery, and B) to provide easy access to physical science tools, reagents and platforms to the broader kidney community to catalyze their research and spur innovation. We will accomplish these goals through four specific aims: 1. Establish a Biomedical Resource Core focused on established nanotechnology methods for cell-specific delivery of therapeutic and diagnostic payloads (small molecules and biologics) 2. Establish a Resource Development Core focused on nascent technologies in diverse areas of physical sciences to catalyse kidney research. 3. Establish an Administrative Core to oversee all operations of the Center and ensure new technologies are made readily available to the kidney research community and 4. Provide an immersive summer SciHigh research program for high school students. A dedicated, energetic and talented transdisciplinary scientific and administrative team at Northwestern and the University of Southern California will ensure NU-NRC fulfills its mission to transform kidney research through physical science solutions and move us closer to realizing its bold vision: physical science solutions to cure kidney diseases.

摘要 – NU-NRC 总体 肾脏疾病影响着 3700 万美国人，使他们面临心血管事件和其他疾病的重大风险。 虽然我们的领域最近取得了令人兴奋的进展，但影响这些令人震惊的。 数字，确定新的治疗靶点、扩大我们对疾病发病机制的理解和 开发针对肾脏中特定细胞类型的新方法为此，我们必须突破学科界限， 建立新的发现平台并与正交学科合作是肾脏领域尚未解决的重大挑战。 研究缺乏能够整合肾脏复杂性和多样性的技术和平台 其设计和执行中的结构、细胞表型和功能。 大学国家资源中心 (NU-NRC) 将利用以下领域的创新来应对这一挑战： 物理科学旨在为肾脏研究人员提供独特的工具、试剂和平台。 资源利用组织和细胞多样性，使其成为强大的发现技术 - 基于肾脏的研究和治疗开发。 NU-NRC 的首要主题是采用强大的物理科学理论、工具、平台和 在物理科学-肾脏资源中心推进肾脏研究的方法。 该中心的目标是 A) 利用物理科学进步提供新方法来解决未满足的问题 肾脏研究和发现中的挑战，以及 B) 提供轻松获取物理科学工具、试剂的机会 我们将向更广泛的肾脏界提供平台，以促进他们的研究并刺激创新。 通过四个具体目标来实现这些目标： 1. 建立一个生物医学资源核心，重点关注 建立了用于细胞特异性递送治疗和诊断有效负载（小 2. 建立一个专注于新兴技术的资源开发核心 物理科学的不同领域来促进肾脏研究 3. 建立一个行政核心来监督。 中心的所有运作并确保新技术可随时用于肾脏研究 社区和 4. 为高中生提供沉浸式夏季 SciHigh 研究计划。 西北大学和西北大学拥有一支敬业、充满活力、才华横溢的跨学科科学和管理团队 南加州大学将确保 NU-NRC 履行其转变肾脏研究的使命 物理科学解决方案，让我们更接近实现其大胆愿景：物理科学解决方案来治愈 肾脏疾病。