COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN

苏丹寄生虫病合作研究

• 批准号: 3091498
• 负责人: JEFFREY F WILLIAMS
• 金额: $ 34.48万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-09-30 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3091498
• 关键词: Africa; communicable disease control; epidemiology; parasitic diseases

This is a collaborative project between biomedical researchers at the Michigan State University schools of medicine, and faculty and staff at the Ministry of Health, and Faculty of Medicine, University of Khartoum, Democratic Republic of Sudan. It focuses on fundamental aspects of three major tropical disease entities which impose major constraints on the health, productivity, progress and potential of the Sudanese people. In the coming year (September 1980-August 1981) we propose to build on the foundations laid by our current efforts in the establishment, renovation and equipping of laboratory and field bases in Sudan, the development of cooperative agreements between scientific participants from all the institutions involved, and the delineation of reasonable programs of investigation, suited to the priorities, environment and immediate opportunities in Sudan. In schistosomiasis, we intend to consolidate our preliminary studies on the spectrum of therapeutic regimens used in Sudan and their place in medical care and preventive medical strategies, by developing a detailed clinical/pharmacological investigative protocol: this will be applied both to the agents presently routinely administered and to others to which we hope to have access as their suitability for trial purposes is evaluated. In malaria, we shall begin to collect and characterize Plasmodium falciparum strains, and measure the effects of immune factors on the outcome of in vitro assays of drug sensitivity. Results will be evaluated in relation to other strains from Africa, Asia and Latin America. Onchocerciasis transmission in Sudan will be studied through field collections of data on vector type, availability and distribution and correlated with epidemiological data on infection rates and intensity in humans. Preliminary studies will be undertaken to develop immunologic reagents for the detection and purification of antigens of O. volvulus for immunopathological work in the future.

这是密歇根州生物医学研究人员之间的合作项目 州立大学医学院，以及教职员工 卫生和医学院，喀土穆大学，民主共和国 苏丹。 它着重于三种主要热带疾病的基本方面 对健康，生产力，进步施加重大限制的实体 和苏丹人民的潜力。 在来年（1980年9月至8月 1981年）我们建议以我们目前的努力为基础建立 苏丹实验室和现场基地的建立，翻新和装备， 科学参与者之间合作协议的发展 所有涉及的机构，以及合理计划的划定 调查，适合优先事项，环境和即时机会 在苏丹。 在血吸虫病中，我们打算巩固我们的初步研究 在苏丹使用的治疗方案及其在医疗中的位置 通过开发详细的护理和预防性医疗策略 临床/药理研究方案：这两者都将应用于 目前，代理商经常管理，我们希望向其他代理商管理 评估了其适合试用目的的访问权限。 在疟疾 我们将开始收集和表征恶性疟原虫菌株，并 测量免疫因子对药物体外测定结果的影响 灵敏度。 结果将根据其他菌株评估 非洲，亚洲和拉丁美洲。 苏丹的OnChocerceriasis传播将是 通过有关向量类型，可用性和 分布并与感染率的流行病学数据相关 人类的强度。 将进行初步研究以发展 免疫试剂用于检测和纯化O的抗原。 未来进行免疫病理学工作的Volvulus。