BIOCIDAL POLYMERS FOR DENTAL WATER CONTAMINATION CONTROL

用于控制牙科用水污染的杀菌聚合物

• 批准号: 2713304
• 负责人: JEFFREY F WILLIAMS
• 金额: $ 9.95万
• 依托单位: HALOSOURCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 1999-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2713304
• 关键词: antiinfective agents; clinical biomedical equipment; communicable disease control; dental research; dentistry; electron microscopy; polymers; surface coating; water microbiology; water quality; water supply; water treatment

In this research proposal an entirely novel chemical technology is applied to a problem of national importance to the healthcare industry, arising from "device related infections" during patient care (1,2). Microbial contamination of in-dwelling devices is commonplace and is not satisfactorily resolved by currently available approaches (silver impregnated catheters, or silver/antimicrobial combinations (3,4)). Recent advances in N- Halamine polymer chemistry permit the creation of "contact biocidal" surfaces expressing rapid, potent efficacy against bacterial and viral pathogens in fluid streams (5,6). New developments provide for coatings to be laid down on substrates commonly used in medical devices; these coatings show about 100% control of Pseudomonas biofilm formation in 72 hour experiments (7). In the proposed studies, quantitative microbiological evaluations of adherent organisms, fluorescence microscopy of live/dead differentiation, and scanning and transmission election microscopy will be used to characterize a range of novel polymeric compounds (7), over time and in the presence of a variety of organic bioburdens. Results will be used in selection of polymeric coating procedures to be evaluated as candidates for further development as components of "infection resistant" devices (such as catheters, shunts, urine and colostomy bags) with far reaching commercial and health care implications nationally and internationally. PROPOSED COMMERCIAL APPLICATION: Commercial applications include cartridges to be included in the dental unit waterlines so as to provide an antimicrobial, decontaminating component in the pathway of water to the patient. Also possible is the development of tubing or devices that could be periodically re-charged with antibacterial activity by exposure to bleach (hypochlorite) as a means of maintaining control over microbial contamination of dental unit water. Application to the control of air quality is also possible, depending on the configuration of the decontamination pathway devised to incorporate the antimicrobial polymers.

在这项研究提案中，一种全新的化学技术应用于解决对医疗保健行业具有全国重要性的问题，该问题是由患者护理期间的“设备相关感染”引起的 (1,2)。留置装置的微生物污染很常见，目前可用的方法（银浸渍导管或银/抗菌组合 (3,4)）无法令人满意地解决这一问题。 N-Halamine 聚合物化学的最新进展允许创建“接触式杀菌”表面，对流体流中的细菌和病毒病原体表现出快速、有效的功效 (5,6)。新的发展使得涂层可以沉积在医疗器械常用的基材上；这些涂层在 72 小时的实验中显示出对假单胞菌生物膜形成的约 100% 控制 (7)。 在拟议的研究中，随着时间的推移和在各种存在的情况下，将使用贴壁生物的定量微生物学评估、活/死分化的荧光显微镜以及扫描和透射电子显微镜来表征一系列新型聚合物（7）。有机生物负载。结果将用于选择聚合物涂层程序，以作为进一步开发的候选方案进行评估，作为“抗感染”装置（例如导管、分流器、尿液和结肠造口袋）的组件，在国内和国际上具有深远的商业和医疗保健影响。拟议的商业应用：商业应用包括安装在牙科综合治疗台水管中的滤筒，以便在通往患者的水路中提供抗菌、净化成分。还可能开发出可以通过暴露于漂白剂（次氯酸盐）来定期补充抗菌活性的管道或装置，作为控制牙科综合治疗台水的微生物污染的一种手段。也可以应用于空气质量控制，具体取决于设计用于掺入抗菌聚合物的净化路径的配置。