BIOCIDAL POLYMERS FOR DENTAL WATER CONTAMINATION CONTROL

用于控制牙科用水污染的杀菌聚合物

• 批准号: 2713304
• 负责人: JEFFREY F WILLIAMS
• 金额: $ 9.95万
• 依托单位: HALOSOURCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 1999-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2713304
• 关键词: antiinfective agents; clinical biomedical equipment; communicable disease control; dental research; dentistry; electron microscopy; polymers; surface coating; water microbiology; water quality; water supply; water treatment

In this research proposal an entirely novel chemical technology is applied to a problem of national importance to the healthcare industry, arising from "device related infections" during patient care (1,2). Microbial contamination of in-dwelling devices is commonplace and is not satisfactorily resolved by currently available approaches (silver impregnated catheters, or silver/antimicrobial combinations (3,4)). Recent advances in N- Halamine polymer chemistry permit the creation of "contact biocidal" surfaces expressing rapid, potent efficacy against bacterial and viral pathogens in fluid streams (5,6). New developments provide for coatings to be laid down on substrates commonly used in medical devices; these coatings show about 100% control of Pseudomonas biofilm formation in 72 hour experiments (7). In the proposed studies, quantitative microbiological evaluations of adherent organisms, fluorescence microscopy of live/dead differentiation, and scanning and transmission election microscopy will be used to characterize a range of novel polymeric compounds (7), over time and in the presence of a variety of organic bioburdens. Results will be used in selection of polymeric coating procedures to be evaluated as candidates for further development as components of "infection resistant" devices (such as catheters, shunts, urine and colostomy bags) with far reaching commercial and health care implications nationally and internationally. PROPOSED COMMERCIAL APPLICATION: Commercial applications include cartridges to be included in the dental unit waterlines so as to provide an antimicrobial, decontaminating component in the pathway of water to the patient. Also possible is the development of tubing or devices that could be periodically re-charged with antibacterial activity by exposure to bleach (hypochlorite) as a means of maintaining control over microbial contamination of dental unit water. Application to the control of air quality is also possible, depending on the configuration of the decontamination pathway devised to incorporate the antimicrobial polymers.

在这项研究建议中，一种完全新颖的化学技术应用于对医疗保健行业的国家重要性问题，这是由于患者护理期间的“相关感染”引起的（1,2）。室内设备的微生物污染很常见，并且没有通过当前可用的方法（银浸渍导管或银/抗菌组合（3,4）来令人满意地解决。 N-葫芦聚合物化学的最新进展允许创建“接触性杀生物”表面，该表面表达了针对流体流中细菌和病毒病原体的快速，有效的功效（5,6）。新的开发项目规定了对医疗设备常用的底物进行涂料；这些涂层在72小时实验中显示了大约100％的假单胞菌生物膜形成（7）。 在拟议的研究中，对粘附生物的定量微生物学评估，生物/死亡分化的荧光显微镜以及扫描和传播选举显微镜将用于表征一系列新型的聚合物化合物（7），随着时间的流逝，随着时间的流逝，以及各种有机生物生物物种的存在。结果将用于选择聚合物涂料程序，以作为进一步开发的候选者评估，作为“抗感染”设备的组成部分（例如导管，分流器，尿液和结肠造口术袋），其在国内和国际上具有遥远的商业和医疗保健意义。拟议的商业应用：商业应用包括将墨盒包含在牙科单元的水线中，以便向患者提供水中的抗菌，衰老的成分。还可能是通过暴露于漂白剂（次氯甲层）来定期重新充电的管道或设备的开发，以维持对牙科单位水的微生物污染的一种手段。还可以在控制空气质量的情况下应用，这取决于设计为结合抗菌聚合物的净化途径的构型。