ANTIMICROBIAL TEXTILES FOR HEALTHCARE WORKER PROTECTION

用于保护医护人员的抗菌纺织品

• 批准号: 2718040
• 负责人: JEFFREY F WILLIAMS
• 金额: $ 6.69万
• 依托单位: HALOSOURCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2718040
• 关键词: communicable disease control; material; occupational health /safety; safety equipment

Healthcare workers are occupationally exposed to infectious agents in body fluids and wastes. Personal protection garments and devices provide physical barriers to prevent strike-through of disease agents onto skin or membranes (1). However, the emergence of new pathogens and drug- resistant strains has heightened awareness of inanimate surfaces, including clothing, as sources of transmissible organisms (2). The need for better protective measures is paramount. Recent advances in textile chemistry permit production of textiles with covalently linked N-Halamine antimicrobial activity, conveniently rechargeable, and expressing rapid, potent efficacy against bacterial and fungal pathogens (3,4). We propose to examine the antiviral/antibacterial capacity of N-Halamine textiles, mimicking circumstances under which antimicrobial fabrics must function to reduce infective risks from contamination. Enveloped (VSV) and non- enveloped viruses (EMCV) and antibiotic-resistant bacteria (VRE, MRSA) in blood, body fluids, will be targeted. Quantitative recovery of inocula applied to textiles subjected to different levels of N-Halamine loading will serve to determine survival of organisms. The experiments should establish the potential for incorporating antimicrobial activity into fabrics, and justify longer term evaluation of the approach using a broader range of pathogens, including HIV. This should lead to on-site assessment of protective benefits of N-Halamine clothing. PROPOSED COMMERCIAL APPLICATIONS: If N-Halamine-treated textiles show speed and effectiveness against important types of viral and bacterial pathogens even in blood and other body fluids, and can eventually be shown to decrease occupational exposure of skin and mucous membranes to disease agents, the commercial implications are many. The finding may lead to incorporation of this novel textile chemistry into production of protective clothing and devices for healthcare workers and others (emergency and law enforcement personnel) who may be at risk of occupational exposure to human pathogens.

医护人员在职业上接触过传染病药物 体液和废物。个人保护服装和设备提供 防止疾病剂撞向皮肤的物理障碍 或膜（1）。但是，新的病原体和药物的出现 抗性菌株提高了对无生命表面的认识， 包括衣服，作为可传染生物的来源（2）。需要 对于更好的保护措施至关重要。纺织品的最新进展 化学允许生产具有共价连接的n-Halamine的纺织品 抗菌活性，方便地充电，表达快速， 针对细菌和真菌病原体的有效疗效（3,4）。我们建议 要检查N-山拉敏纺织品的抗病毒/抗菌能力， 模仿抗菌织物必须起作用的情况 减少污染中的感染风险。包裹（VSV）和非 - 包络病毒（EMCV）和抗生素耐药菌（VRE，MRSA） 在血液中，体液将被靶向。接种物的定量恢复 适用于承受不同级别的N-卤化物加载的纺织品 将用于确定生物的生存。实验应该 确定将抗菌活性纳入 织物，并证明使用A的长期评估是合理的 包括艾滋病毒在内的更广泛的病原体。这应该导致现场 评估N-甲胺服装的保护益处。 拟议的商业应用： 如果N-HALAMINE处理的纺织品显示出速度和有效性 重要类型的病毒和细菌病原体，即使在血液和其他 体液，最终可以证明可以减少职业 皮肤和粘膜暴露于疾病剂，商业 含义很多。这一发现可能导致纳入其中 新颖的纺织化学反应到保护性服装的生产和 医疗工作者和其他人的设备（紧急和执法部门 人员）可能有职业接触人的风险 病原体。