BIOCIDAL POLYMERS FOR CONTROL OF DEVICE CONTAMINATION

用于控制设备污染的杀菌聚合物

• 批准号: 2715724
• 负责人: JEFFREY F WILLIAMS
• 金额: $ 9.99万
• 依托单位: HALOSOURCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-15 至 1999-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2715724
• 关键词: antiseptic sterilization; biomaterial development /preparation; biomaterial evaluation; catheterization; chemical synthesis; clinical biomedical equipment; colon surgery; copolymer; fluorescence microscopy; method development; nosocomial infection control; polymers; scanning electron microscopy; transmission electron microscopy; urinary catheterization

In this research proposal an entirely novel chemical technology is applied to a problem of national importance to the healthcare industry, arising from "device related infections" during patient care (1,2). Microbial contamination of in-dwelling devices is commonplace and is not satisfactorily resolved by currently available approaches (silver impregnated catheters, or silver/antimicrobial combination (3,4)). Recent advances in N-Halamine polymer chemistry permit the creation of "contact biocidal" surfaces expressing rapid, potent efficacy against bacterial and viral pathogens in fluid stream (5,6). New developments provide for coatings to be laid down on substrates commonly used in medical devices; these coating show about 100% control of Pseudomonas biofilm formation in 72 hour experiments (7). In the proposed studies, quantitative micro-biological evaluations of adherent organisms, fluorescence microscopy of live/dead differentiation, and scanning and transmission electron microscopy will be used to characterize a range of novel polymeric compounds (7), over time and in the presence of a variety of organic bioburdens. Results will be used in selection of polymeric coating procedures to be evaluated as candidates for further development as components of "infection resistant" devices (such as catheters, shunts, urine and colostomy bags) with far reaching commercial and health care implications nationally and internationally. PROPOSED COMMERCIAL APPLICATION: Novel N-Halamine polymers could prove valuable in the control and prevention of microbial contamination of the surfaces of many medical devices. Polymer coatings can now be created with a wide range of physicochemical characteristics suitable for production of contact biocidal surfaces on substrates commonly used in medical catheters and other devices, such as polyurethane. Successful inhibition of bacterial adhesion and colonization could open up commercial product opportunities that address device related infections, a problem of enormous significance to the health-care industry nationally and internationally.

在这项研究建议中，一种完全新颖的化学技术是 适用于对医疗保健行业的国家重要性的问题， 由患者护理期间的“相关感染”引起（1,2）。 室内设备的微生物污染很常见，不是 通过当前可用的方法令人满意地解决（银 浸渍的导管或银/抗菌组合（3,4）。 N-卤化聚合物化学的最新进展允许创建 “接触杀生物”表面，表达了快速，有效的功效 流体流中的细菌和病毒病原体（5,6）。新事态发展 提供在通常使用的基材上放置涂料 医疗设备；这些涂层显示假单胞菌的100％控制 72小时实验中的生物膜形成（7）。在拟议的研究中， 定量的微生物学评估，对粘附生物， 活/死分化，扫描和 透射电子显微镜将用于表征范围 随着时间的流逝，新型聚合化合物（7）的存在 各种有机生物库。结果将用于选择 聚合物涂料程序将作为候选者进行评估 作为“抗感染”设备的组成部分的开发（例如 导管，分流器，尿液和结肠造口袋） 国内和国际上的商业和医疗保健影响。 拟议的商业应用： 新型的N-夏服聚合物可以证明在控制中很有价值 预防许多医学表面的微生物污染 设备。现在可以使用广泛的聚合物涂料来创建 适合生产接触的物理化学特征 在医疗导管和 其他设备，例如聚氨酯。成功抑制细菌 粘附和殖民化可以打开商业产品机会 该解决与设备相关的感染的解决方案，这是一个巨大的问题 在国内和国际上对医疗保健行业的意义。