COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN

苏丹寄生虫病合作研究

基本信息

批准号：
3091503
负责人：
JEFFREY F WILLIAMS
金额：
$ 28.62万
依托单位：
BRIGHAM YOUNG UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-09-01 至 1994-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3091503
关键词：
Africa parasitic disease chemotherapy parasitic diseases

项目摘要

The overall project objective is to carry forward a collaborative program of tropical parasitic disease research on several basic problems which underlie the major health priorities of the Republic of Sudan. The solutions we seek should permit inferences to be drawn which are of value to those involved in the characterization, prevention, treatment and control of parasitic diseases elsewhere in the tropics. Four widespread and important human parasitoses will be addressed: malaria, schistosomiasis, onchocerciasis and leishmaniasis. Malaria is by far the most important disease in Sudan; in the absence of chemotherapeutic or vector control interventions the outcome of infection is largely the result of host-immune response - parasite interactions. The nature of these, specifically with regard to T cell responsiveness to defined antigens and the pattern of cell-mediated effector mechanisms in well characterized subsets of endemic area populations form the focus for proposal #1. Contemporary approaches to schistosomiasis in the field depend on widespread use of anthelmintic drugs. The accurate assessment of their impact in terms of pathology and its resolution has only recently become possible using non-invasive ultrasound technology. In proposal #2 we extend our findings on cross-sectional analysis of Symmer;s fibrosis in affected communities to include biochemical and immunological correlates of the onset and disposition of pathologic changes in this most important component of schistosomal disease. The potential impact of ivermectin, a newly developed microfilaricidal agent, on onchocerciasis in Sudan is enormous. However, major questions remain about its pharmacology and mode of action and the role of host-immune responses in its efficacy in vivo and the adverse consequences of treatment. These will be explored in proposal #3 on onchocerciasis. Leishmaniasis, common in rural areas of eastern Sudan, involves immune mechanisms in its pathogenesis which are not well characterized. Longitudinal monitoring of cell-mediated and immunoglobulin types of responses in persons at different disease stages and during and after treatment will be used to establish mechanisms in its pathogenesis which are not well characterized. Longitudinal monitoring of cell-mediated and immunoglobulin types of responses in persons at different disease stages and during and after treatment will be used to establish mechanisms that operate in pathogenesis and after treatment will be used to establish mechanisms that operate in pathogenesis and in the onset of cure and perhaps protection (Project #4. Sustained involvement of Sudanese administrators, professionals, and technicians throughout this program will ensure enhancement of national research capacity for the future, and the research results should contribute to improvements in health care for the affected human populations throughout the country.

总体项目目标是进行协作计划关于几个基本问题的热带寄生疾病研究是苏丹共和国的主要健康重点。这我们寻求的解决方案应允许提出有价值的推论涉及参与特征，预防，治疗和控制热带其他地方的寄生疾病。四个广泛并将解决重要的人类寄生虫：疟疾，血吸虫病，chocerceriasis和Leishmanisis。到目前为止，疟疾是苏丹最重要的疾病；在没有化学治疗或向量控制干预措施感染的结果在很大程度上是宿主免疫反应的结果 - 寄生虫相互作用。的本质这些，特别是关于T细胞对定义的响应的抗原和细胞介导的效应器机制的模式特有的特有地区人口的亚集构成了重点提案＃1。现代的血吸虫病方法取决于广泛使用驱虫药。准确的评估它们在病理学及其解决方面的影响只有最近使用非侵入性超声技术成为可能。在提案＃2我们扩展了我们的发现在受影响社区中的纤维化包括生化和病理发作和处置的免疫学相关性血吸虫病最重要组成部分的变化。这伊维菌素的潜在影响，一种新开发的微丝剂，在苏丹的尾尾cer虫上是巨大的。但是，仍然存在主要问题关于它的药理学和作用方式以及宿主免疫的作用其体内功效的反应和治疗。这些将在OnChocerciasis提案3中进行探讨。利什曼病在苏丹东部农村地区常见，涉及免疫其发病机理中的机制未得到很好的特征。细胞介导的和免疫球蛋白类型的纵向监测在不同疾病阶段以及之后和之后的人反应治疗将用于在其发病机理中建立机制没有很好的特征。细胞介导的纵向监测和在不同疾病阶段的人的免疫球蛋白类型的反应类型在治疗期间和之后，将用于建立机制在发病机理和治疗后将使用以建立在发病机理和治愈发作中起作用的机制也许保护（项目＃4。苏丹人的持续参与整个计划的管理人员，专业人士和技术人员将确保增强未来国家研究能力，并研究结果应有助于改善医疗保健全国受影响的人口。

项目成果

期刊论文数量（100）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

African serum interference in the determination of chloroquine sensitivity in Plasmodium falciparum.

非洲血清干扰恶性疟原虫氯喹敏感性测定。

DOI：
10.1007/bf00926589
发表时间：
1984
期刊：
Zeitschrift fur Parasitenkunde (Berlin, Germany)
影响因子：
0
作者：
Carlin,JM;VandeWaa,JA;Jensen,JB;Akood,MA
通讯作者：
Akood,MA

Chromosomes of Babesia bovis and Babesia bigemina.

牛巴贝虫和二联巴贝虫的染色体。

DOI：
10.1016/0166-6851(92)90041-h
发表时间：
1992
期刊：
Molecular and biochemical parasitology
影响因子：
1.5
作者：
Ray,BK;Bailey,CW;Jensen,JB;Carson,CA
通讯作者：
Carson,CA

Prospects for prophylaxis of parasitism.

预防寄生的前景。

DOI：
10.1016/0020-7519(87)90149-4
发表时间：
1987
期刊：
International journal for parasitology
影响因子：
4
作者：
Williams,JF
通讯作者：
Williams,JF

Plasma chloroquine measurement in the evaluation of Plasmodium falciparum sensitivity.

血浆氯喹测量评价恶性疟原虫敏感性。

DOI：
发表时间：
1990
期刊：
The Journal of tropical medicine and hygiene
影响因子：
0
作者：
Saeed,BO;Hassabalrasoul,MA;Ibrahim,KE;Abdel-Karim,EI;Salih,SA;Hassan,IM;Khider,S;Bayoumi,RA
通讯作者：
Bayoumi,RA

Lack of cross-resistance to 4-aminoquinolines in chloroquine-resistant Plasmodium falciparum in vitro.

体外耐氯喹恶性疟原虫对 4-氨基喹啉缺乏交叉耐药性。