Parental Occupation and Childhood Cancers

父母职业与儿童癌症

• 批准号: 8456948
• 负责人: Julia Heck
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-15 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8456948
• 关键词: Adult; Animals; Area; Birth; Brain Neoplasms; Cadmium; Calcitriol; Cancer Control; Cancer Etiology; Carcinogens; Case-Control Studies; Categories; Cause of Death; Central Nervous System Neoplasms; Cessation of life; Child; Childhood; Childhood Leukemia; Chromium; Classification; Cohort Studies; Collaborations; Communicable Diseases; Complex; Data; Data Collection; Data Set; Databases; Denmark; Detection; Diagnosis; Diethylstilbestrol; Digit structure; Disease; Dust; Economics; Employment; Epidemiologic Studies; Etiology; Exposure to; Fathers; Fetus; Funding; Gases; Genetic Predisposition to Disease; Hematologic Neoplasms; Hematopoietic; Home environment; Human; Industry; International; International Agency for Research on Cancer; Ionizing radiation; Lead; Length; Light; Link; Literature; Livestock; Location; Malignant Bone Neoplasm; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of central nervous system; Manganese; Meat; Medical History; Metals; Mothers; Motor Vehicles; Nephroblastoma; Nested Case-Control Study; Nickel; Occupational; Occupational Exposure; Occupational Health; Occupational Malignant Neoplasm; Occupations; Paint; Paper; Parents; Particulate; Paternal Exposure; Pensions; Persons; Pigments; Policies; Population; Prevention strategy; Production; Publishing; Recording of previous events; Registries; Regulation; Research; Resources; Risk; Risk Factors; Safety; Sampling; Smoking; Solvents; Source; Sun Exposure; Techniques; Textiles; Therapeutic; Time; Virus; Welding; Woman; Wood material; Work; Workplace; asphalt; base; cancer risk; cancer type; case control; chemotherapeutic agent; cohort; design; environmental chemical; exhaust; interest; leukemia; men employment; mortality; neoplasm registry; population based; prospective; social; tool; tumor; women employment

DESCRIPTION (provided by applicant): Cancer is the second leading cause of death among children, but despite extensive research, the etiology of childhood cancers remains largely unknown. The workplace is an important source of environmental chemicals and other agents and these exposures may be inadvertently transferred to the fetus or to the home. Research on parental occupational exposures and childhood cancer has suggested several links, but there remain areas of research that are understudied, with one of the most notable gaps being a lack of information on maternal occupational exposures. We propose a large (N=537,000) nested case-control study of children born in Denmark 1965-2010 to examine risks of cancer from parental occupational exposures. Cases will be taken from the Denmark Cancer Registry and controls will be selected at random from the Denmark Central Population Registry. We will have additional information on each child's peri-natal history from the Medical Births Registry. Information on parental job titles is available from the Central Population Registry and information on industry of employment will be taken from the Supplementary Pension Fund, a supplement to the state pension that was established in 1964 and retains information on all employed persons residing in Denmark. We will further use job-exposure matrices that have been previously developed for studies of occupational health in Denmark. Our aims are to focus on maternal occupational exposures and specific hypotheses of suspected carcinogens that have been observed in the literature. This proposal presents an exciting opportunity to identify specific cancer-occupational links, with the possibility of informing policy on workplace safety regulation and encouraging research on therapeutic and preventive strategies.

描述（由申请人提供）：癌症是儿童死亡的第二大原因，但尽管进行了广泛的研究，儿童癌症的病因仍然很大程度上未知。工作场所是环境化学品和其他物质的重要来源，这些接触可能会无意中转移到胎儿或家里。关于父母职业暴露和儿童癌症的研究表明了一些联系，但仍有一些研究领域尚未得到充分研究，其中最显着的差距之一是缺乏关于母亲职业暴露的信息。我们建议对 1965 年至 2010 年在丹麦出生的儿童进行一项大型（N = 537,000）巢式病例对照研究，以检查父母职业暴露导致的癌症风险。病例将从丹麦癌症登记处抽取，对照将从丹麦中央人口登记处随机选择。我们将从医疗出生登记处获得有关每个孩子围产期病史的更多信息。有关父母职称的信息可从中央人口登记处获得，有关就业行业的信息将从补充养老金基金中获取，该基金是 1964 年设立的国家养老金的补充，保留了居住在丹麦的所有就业人员的信息。我们将进一步使用之前为丹麦职业健康研究而开发的工作暴露矩阵。我们的目标是关注母亲的职业暴露和文献中观察到的可疑致癌物的具体假设。该提案提供了一个令人兴奋的机会来确定特定的癌症与职业之间的联系，并有可能为工作场所安全监管政策提供信息，并鼓励治疗和预防策略的研究。

项目成果

The risk of childhood brain tumors associated with delivery interventions: A Danish matched case-control study.

• DOI: 10.1016/j.canep.2021.102077
• 发表时间: 2022-03
• 期刊: Cancer epidemiology
• 影响因子: 2.6
• 作者: Yeh KW;He D;Hansen J;Carpenter CL;Ritz B;Olsen J;Heck JE
• 通讯作者: Heck JE

A review and meta-analysis of outdoor air pollution and risk of childhood leukemia.

• DOI: 10.1080/10590501.2015.1002999
• 发表时间: 2015
• 期刊: Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
• 作者: Filippini T;Heck JE;Malagoli C;Del Giovane C;Vinceti M
• 通讯作者: Vinceti M

Parental occupational organic dust exposure and selected childhood cancers in Denmark 1968-2016.

• DOI: 10.1016/j.canep.2020.101667
• 发表时间: 2020-04
• 期刊: Cancer epidemiology
• 影响因子: 2.6
• 作者: Volk J;Heck JE;Schmiegelow K;Hansen J
• 通讯作者: Hansen J

Parental age and childhood cancer risk: A Danish population-based registry study.

• DOI: 10.1016/j.canep.2017.06.010
• 发表时间: 2017-08
• 期刊: Cancer epidemiology
• 影响因子: 2.6
• 作者: Contreras ZA;Hansen J;Ritz B;Olsen J;Yu F;Heck JE
• 通讯作者: Heck JE

Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study.

母亲在怀孕期间接触苯和 PM10 是否会增加先天畸形的风险？

• DOI: 10.1016/j.scitotenv.2015.09.051
• 发表时间: 2016
• 期刊: The Science of the total environment
• 作者: Vinceti,Marco;Malagoli,Carlotta;Malavolti,Marcella;Cherubini,Andrea;Maffeis,Giuseppe;Rodolfi,Rossella;Heck,JuliaE;Astolfi,Gianni;Calzolari,Elisa;Nicolini,Fausto
• 通讯作者: Nicolini,Fausto