Maternal acetaminophen use and childhood cancer

母亲使用对乙酰氨基酚与儿童癌症

• 批准号: 10852089
• 负责人: Julia Heck
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF NORTH TEXAS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10852089
• 关键词: Acetaminophen; Address; Administrative Supplement; Age; Amblyopia; Asthma; Autoimmune Diseases; Birth; Caring; Case/Control Studies; Cerebral Palsy; Child; Childhood Leukemia; Chronic Obstructive Pulmonary Disease; Code; Cohort Studies; Colitis; Collaborations; Communities; Complex Analysis; Confounding Factors (Epidemiology); Congenital Heart Defects; Control Groups; Data; Databases; Denmark; Diagnosis; Diagnostic; Down Syndrome; Eczema; Epilepsy; Foundations; Funding; Goals; Grant; Guidelines; Health; Hospitals; Hypertension; ICD-9; Individual; Infantile spasms; Intake; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Investigation; Link; Longevity; Malignant Childhood Neoplasm; Malignant Neoplasms; Managed Care; Maternal Age; Maternal and Child Health; Medical; Medical Records; Mental Health; Musculoskeletal; National Health Insurance; Obstructive Sleep Apnea; Occupational; Parents; Participant; Patient Care Management; Patients; Persons; Pharmacologic Substance; Phenotype; Pneumonia; Population; Population Registers; Pregnancy; Prevalence; Prevalence Study; Registries; Reporting; Research; Research Design; Resources; Risk; Risk Estimate; Sample Size; Sampling; Selection Bias; Taiwan; Thyroid Gland; abortion; autism spectrum disorder; cancer diagnosis; cohort; community setting; comorbidity; early childhood; health care service utilization; hypercholesterolemia; improved; leukemia; neoplasm registry; population based; prenatal; prospective; respiratory; screening; screening guidelines; young adult

Project Summary/Abstract This proposal is responsive to NOT-OD-22-137: Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. We aim to address Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” We will build upon our large study of 2.3 million Taiwanese births, in which we are investigating maternal pharmaceutical intake in pregnancy and associations with childhood cancer; Aims of the parent study will not change. In the US, the population prevalence of Down syndrome (DS) is 250,000 persons, and 6000 children with DS are born in the US each year. Children with Down syndrome have a substantially increased risk for leukemia, and elevated risk for a number of other conditions. The proposed study will utilize data from a large cohort of Taiwanese children to examine comorbid conditions in children with Down syndrome. Participants in our study include all children born in Taiwan 2004-2015. Down syndrome and other diagnoses will be ascertained from the National Health Insurance Database in Taiwan. Results will be confirmed in a large cohort of Danish children. The goals of this project are to better understand comorbidities in Down syndrome to improve screening guidelines and management of patient care.

项目摘要/摘要 该提案对NOT-OD-22-137的响应：包括 （研究整个生命周期的同时发生条件以了解唐氏综合症）项目。我们的目标 解决组件2：“在整个生命周期中，大量患有唐氏综合症的人组装到 进行深度表型和研究共存条件。 台湾出生，我们正在研究怀孕和关联的材料药物摄入量 儿童癌；父母研究的目的不会改变。在美国，人口流行率 综合征（DS）为25万人，每年美国有6000名DS儿童出生。有孩子的孩子 综合征对白血病的风险大大增加，并且许多其他疾病的风险升高。 拟议的研究将利用大量台湾儿童的数据检查合并症 在唐氏综合症的儿童中。我们研究的参与者包括所有在2004 - 2015年台湾出生的孩子。向下 将从台湾的国家健康保险数据库中确定综合征和其他诊断。 结果将在大量丹麦儿童中得到确认。该项目的目标是更好地理解 唐氏综合症的合并症，以改善筛查指南和患者护理的管理。