Childhood Cancer and Industrial Pollution (CHIP)

儿童癌症与工业污染 (CHIP)

• 批准号: 10046486
• 负责人: Julia Heck
• 金额: $ 14.99万
• 依托单位: UNIVERSITY OF NORTH TEXAS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10046486
• 关键词: Acute Lymphocytic Leukemia; Address; Adult; Air Pollution; Birth; Birth Records; California; Carcinogens; Case-Control Studies; Categories; Cause of Death; Central Nervous System Neoplasms; Chemical Exposure; Chemicals; Child; Childhood; Chronic; Data; Data Reporting; Development; Disease; Environment; Environmental Exposure; Environmental Health; Etiology; Exposure to; Funding; General Population; Goals; Government regulations; Health; Health Status; Hematologic Neoplasms; Human; Industrial Waste; Industrialization; Industry; International Agency for Research on Cancer; Justice; Knowledge; Lead; Life; Link; Literature; Malignant Childhood Neoplasm; Malignant Neoplasms; Measurement; Nephroblastoma; Neuroblastoma; Nickel; Occupational Exposure; Outcome; Pesticides; Poison; Pollution; Population Study; Pregnancy; Prevention; Prevention strategy; Recommendation; Recording of previous events; Recovery; Recycling; Reporting; Research; Research Design; Research Personnel; Resources; Retinoblastoma; Rhabdomyosarcoma; Risk; Sample Size; Sampling; Selection Bias; Site; Source; Specific qualifier value; Survivors; Techniques; Testing; Tetrachloroethylene; Toxic Environmental Substances; Toxics Release Inventory; Trichloroethanes; United States Environmental Protection Agency; United States National Institutes of Health; Waste Management; Work; air monitoring; anticancer research; base; cancer risk; cancer subtypes; cancer type; carcinogenicity; cohort; early childhood; environmental chemical; experience; interest; land use; leukemia; neoplasm registry; pesticide exposure; pollutant; population based; prospective

Project summary Cancer is the leading cause of death by disease among children, with an expected 11,060 childhood cancer cases in 2019. The effects of pediatric cancers extend beyond early life, with survivors having diminished health status and a greater risk for chronic health problems in comparison to the general population. In adults, it is clearly established that occupational exposure to very high levels of specific agents has increased cancer risks. Environmental toxins are strongly suspected by the public to contribute etiologically to pediatric cancers, and it is important that the environmental determinants of pediatric cancers are systematically investigated to support or refute these links. The proposed project is a population-based case-control study of exposure to industrial pollution in pregnancy and early childhood in relation to childhood cancer development. We propose to take cases from two NIH-funded studies (the Air Pollution and Childhood Cancers study and the Pesticide Exposure and Childhood Cancers study) and examine residential proximity to sources of industrial pollution; we have previously reconstructed full residential histories for a portion of our sample. Controls were selected at random from California birth records (N=29,445 cases of specified childhood cancer types, 983,440 controls). Exposure measurements will be taken from the Environmental Protection Agency's Toxics Release Inventory (TRI). The exposures of primary interest in the proposed study include suspected and established carcinogens which are amongst the most commonly released toxic agents by industries in California. We will focus on agents of particular interest for carcinogenic review by the International Agency for Research on Cancer. The study's wealth of existing data on other environmental exposures and potential confounders, in addition to the use of GIS for development of detailed exposure metrics, will enable the investigators to make an actionable contribution to the current state of knowledge regarding environmental causes of pediatric cancers.

项目摘要 癌症是儿童疾病死亡的主要原因，预计有11,060个儿童癌症 2019年的病例。儿科癌症的影响超出了早期生活，幸存者的影响减少了 与普通人群相比，健康状况和慢性健康问题的风险更大。在成年人中 显然已经确定，职业暴露于极高的特定药物会增加癌症 风险。公众强烈怀疑环境毒素，以对儿科癌症的病因做出贡献， 重要的是，对小儿癌的环境决定因素进行系统的研究 支持或反驳这些链接。拟议的项目是基于人群的病例对照研究 与儿童癌症发展有关的怀孕和幼儿期的工业污染。我们建议 从两项NIH资助的研究中采取病例（空气污染和儿童期癌症研究和农药 暴露和童年癌研究）并检查与工业污染源的住宅邻近性； 我们以前已经重建了一部分样本的完整住宅历史。选择对照 从加利福尼亚的出生记录中随机（n = 29,445例指定的儿童癌症类型，983,440 控件）。曝光测量将从环境保护局的毒物释放中进行 库存（TRI）。拟议的研究中，主要兴趣的暴露包括可疑和已建立 致癌物是加利福尼亚州行业最常见的有毒药物之一。我们将 专注于国际研究机构对致癌审查特别感兴趣的代理人 癌症。该研究在其他环境暴露和潜在混杂因素的现有数据中拥有丰富的财富 除了使用GIS开发详细的暴露指标，还将使研究人员能够使 对有关小儿环境原因的当前知识状态的可行贡献 癌症。