Mentoring Multidisciplinary Patient-Oriented Research in TB, HIV, and Global Health

指导结核病、艾滋病毒和全球健康领域的多学科、以患者为导向的研究

• 批准号: 10619230
• 负责人: Nippie Sarita Shah
• 金额: $ 19.53万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-23 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10619230
• 关键词: Affect; Area; Base Pairing; COVID-19; COVID-19 pandemic; COVID-19 pandemic effects; Cause of Death; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Data; Clinical Research; Clinical Trials; Clonal Expansion; Collaborations; Communicable Diseases; Communities; Data; Diagnosis; Disease; Drug resistance in tuberculosis; Ensure; Environment; Epidemic; Epidemiologist; Epidemiology; Extreme drug resistant tuberculosis; Foundations; Funding; Funding Opportunities; Genomics; Goals; HIV; HIV/TB; Health; Health Policy; Household; Immunology; Incidence; Individual; Interdisciplinary Study; International; K-Series Research Career Programs; Knowledge; Lead; Link; Location; M. tuberculosis genome; Measurement; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Molecular Epidemiology; Multi-Drug Resistance; Multidrug-Resistant Tuberculosis; Mycobacterium tuberculosis; Parents; Participant; Patient Care; Pattern; Persons; Pharmacology; Physicians; Policies; Prevention; Public Health; Research; Research Infrastructure; Resources; Rifampicin resistance; Role; Science; Scientific Advances and Accomplishments; Scientist; Social Mobility; South Africa; Specimen; Structure; Time; Training; Treatment outcome; Tuberculosis; United States National Institutes of Health; Universities; Work; career; career development; co-infection; community setting; design; detection limit; effective intervention; epidemiologic data; epidemiology study; experience; genome sequencing; global health; improved; innovation; insight; interest; mathematical model; multidisciplinary; mycobacterial; next generation; novel; novel diagnostics; novel therapeutics; patient oriented; patient oriented research; prevent; programs; research study; resistant strain; skills; social; social contact; success; training opportunity; transmission process; whole genome; Affect; Area; Base Pairing; COVID-19; COVID-19 pandemic; COVID-19 pandemic effects; Cause of Death; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Data; Clinical Research; Clinical Trials; Clonal Expansion; Collaborations; Communicable Diseases; Communities; Data; Diagnosis; Disease; Drug resistance in tuberculosis; Ensure; Environment; Epidemic; Epidemiologist; Epidemiology; Extreme drug resistant tuberculosis; Foundations; Funding; Funding Opportunities; Genomics; Goals; HIV; HIV/TB; Health; Health Policy; Household; Immunology; Incidence; Individual; Interdisciplinary Study; International; K-Series Research Career Programs; Knowledge; Lead; Link; Location; M. tuberculosis genome; Measurement; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Molecular Epidemiology; Multi-Drug Resistance; Multidrug-Resistant Tuberculosis; Mycobacterium tuberculosis; Parents; Participant; Patient Care; Pattern; Persons; Pharmacology; Physicians; Policies; Prevention; Public Health; Research; Research Infrastructure; Resources; Rifampicin resistance; Role; Science; Scientific Advances and Accomplishments; Scientist; Social Mobility; South Africa; Specimen; Structure; Time; Training; Treatment outcome; Tuberculosis; United States National Institutes of Health; Universities; Work; career; career development; co-infection; community setting; design; detection limit; effective intervention; epidemiologic data; epidemiology study; experience; genome sequencing; global health; improved; innovation; insight; interest; mathematical model; multidisciplinary; mycobacterial; next generation; novel; novel diagnostics; novel therapeutics; patient oriented; patient oriented research; prevent; programs; research study; resistant strain; skills; social; social contact; success; training opportunity; transmission process; whole genome

Dr. Shah is a physician-scientist with 15 years of experience leading patient-oriented research (POR) on diagnosis, treatment, and prevention of tuberculosis (TB) globally, including drug-resistant TB and TB/HIV co- infection. Her experience with U.S. and international public health programs, including the Centers for Disease Control & Prevention (CDC) where she trained and worked for a decade, provides a strong foundation for integrating research into policy and patient care. This K24 award will allow her to enhance and expand her successful mentorship in POR by providing vital protected time for training in advanced methods for studying TB transmission, and developing a structured mentoring program. Worldwide, TB is the leading cause of death among people living with HIV, with drug-resistant TB threatening decades of progress in TB and HIV control. Drug-resistant TB epidemics are driven primarily by person-to-person transmission of resistant strains, and innovative approaches to improve our understanding of TB transmission are urgently needed to guide effective interventions. Similarly, there is a need to train the next generation of scientists in multidisciplinary TB/HIV and global health POR. Dr. Shah’s robust research program supported by NIH, Gates Foundation, and CDC provides exciting training opportunities that attract trainees interested in multidisciplinary TB & HIV POR. She has a strong track record of mentorship of U.S. and international trainees in diverse areas of TB & HIV clinical research, and many of her mentees have pursued academic careers and K awards. In addition, through her role as Director of the Clinical Core for the NIH P30 Emory/Georgia TB Research Advancement Center and mentor on D43 and T32 programs, she is well placed to provide outstanding research and training opportunities. Biospecimens, clinical, and epidemiologic data from Dr. Shah’s ongoing NIH R01-funded CONTEXT study provide new opportunities for insights into TB transmission, including the impact of the COVID-19 pandemic on social contact patterns that are a key factor in disease spread. The CONTEXT study will serve as the parent study for the new research proposed in this K24 that will: 1) characterize Mtb genomic relatedness using long-read sequencing and evaluate the impact on transmission networks; and 2) characterize changes in social contact patterns during the COVID-19 pandemic and estimate the impact on TB incidence. Each aim is designed to integrate mentees who have experience and interest in growing their careers in these emerging areas of TB transmission science. Dr. Shah’s research and mentoring program is facilitated by her long-standing, cross-disciplinary collaborations with leading experts in mycobacterial genomics, pharmacology, immunology, clinical trials, and mathematical modeling. In addition, the outstanding training resources, funding opportunities, and research infrastructure at Emory will be integrated into Dr. Shah’s mentoring program to create an environment that enables the success of her trainees to pursue independent, impactful careers in TB, HIV, and global health POR.

Shah博士是一位身体科学家，拥有15年的经验领先的以患者为导向的研究（POR） 全球结核病（TB）的诊断，治疗和预防，包括耐药结核和TB/HIV共同 感染。她在美国和国际公共卫生计划中的经验，包括疾病中心 控制与预防（CDC），她训练和工作了十年，为 将研究整合到政策和患者护理中。这个K24奖将使她能够增强和扩展她 通过为研究的高级方法提供重要的保护时间，在POR中成功进行了训练 结核病传播，并制定结构化的心理计划。全球，结核病是死亡的主要原因 在患有艾滋病毒的人中，在结核病和艾滋病毒控制方面具有抗药性结核病威胁性数十年。 抗药性结核病发作是由抗性菌株的人对人传播而驱动的， 迫切需要采用创新的方法来提高我们对结核病传播的理解以指导有效 干预措施。同样，有必要在多学科结核/艾滋病毒中培训下一代科学家 全球卫生局。 Shah博士的强大研究计划，由NIH，盖茨基金会和CDC支持 提供令人兴奋的培训机会，吸引多学科TB和HIV POR有趣的学员。她 在TB＆HIV临床领域的美国和国际学员的心态有很强的记录 研究及其许多梅内斯（Menees）都从事学术职业和K奖。另外，通过她 作为NIH P30 Emory/Georgia TB研究进步中心的临床核心主任和 Menor在D43和T32计划中，她很适合提供出色的研究和培训 机会。 Shah持续的NIH R01资助的生物测量，临床和流行病学数据 上下文研究为了解结核病传播提供了新的机会，包括 COVID-19关于社会接触模式的大流行，这是疾病传播的关键因素。上下文研究 将作为本k24中提出的新研究的家长研究，该研究将：1）特征MTB基因组。 使用长阅读测序的相关性并评估对传输网络的影响；和2） 表征在19日大流行期间社会接触模式的变化并估计对结核病的影响 发病率。每个目标旨在整合有经验和兴趣发展的男性 TB传播科学的这些新兴领域的职业。 Shah博士的研究和心理计划是 她与分枝杆菌领先专家长期以来的跨学科合作促进了 基因组学，药理学，免疫学，临床试验和数学建模。此外，杰出的 Emory的培训资源，资金机会和研究基础设施将被整合到Dr. Shah的心理计划，以创造一个使她的培训成功购买的环境 结核病，艾滋病毒和全球卫生局的独立，有影响力的职业。