BRIDGES for Evaluation of Health Outcomes, Repercussions and Impacts in Zones of

评估健康结果、后果和影响的桥梁

• 批准号: 8133631
• 负责人: Kim A. Anderson
• 金额: $ 32.74万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-11-22 至 2012-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8133631
• 关键词: Address; Affect; Air; Ames Assay; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Assay; Biological Availability; Chemicals; Collaborations; Communities; Coupled; Data; Detection; Development; Devices; Diagnostic; Disasters; Embryo; Environmental Exposure; Environmental Health; Evaluation; Exposure to; Fingerprint; Florida; Generations; Goals; Grant; Health; Health Professional; Health education; Human; In Situ; Individual; Internet; Life; Louisiana; Measurement; Measures; Methods; Mexico; Modeling; Oils; Online Systems; Outcome; Pattern Recognition; Process; Public Health; Reaction; Relative (related person); Research Project Grants; Risk; Risk Assessment; Sampling; Site; Source; Superfund; System; Technology; Testing; Time; Toxic effect; Uncertainty; Water; Work; Zebrafish; analytical tool; chemical spill; environmental stressor; hazard; innovation; microbial; novel; organic contaminant; outreach; response; tool; zebrafish development

DESCRIPTION (provided by applicant): The goals of the proposed project will be to use passive samplers in the Gulf of Mexico before, during and post impact from the Deepwater Horizon Spill of 2010. The passive samplers are biological response indicator devices for gauging environmental stressors (BRIDGES) developed as part of a Superfund Center grant. The devices are air and water passive sampling devices (PSD) that bridge environmental exposure and biological response/effect. They can provide for high throughput samples and rapid turnaround of data. They sequester polycyclic aromatic hydrocarbons (PAHs), oxygenated PAHs (OPAHs) as well as other organic contaminants. OPAHs are potentially more mobile, bioavailable and/or persistent than PAHs. There is growing evidence that OPAHs have important toxicological significance. Dispersants that increase bioavailability coupled with sites exposed to UV may increase OPAHs. The use of complementary bioanalytical tools that quantify bioavailability PAH processes is important to understand disasters such as chemical spill risk. Specific Aim 1: Deploy a set of BRIDGES, air and water bio-analytical tools, regionally in the Gulf of Mexico before, during and post impact to quantitatively sequester bioavailable contaminants. Specific Aim 2: Develop discriminatory pattern recognition and multivariate regression assessments of components in PSD extracts and contaminant source type. Specific Aim 3: Utilize the zebrafish developmental model and Ames assay to test the relative potency of pre-, during and post-impact Deepwater Horizon spill BRIDGES extracts. From a translational perspective, a significant data gap currently exists with respect to oxygenated PAHs and the risk assessment process, currently only the 16 priority PAHs in air is EPA's focus. OPAHs are known to be important hazards, the detection and quantification will provide new and very important information on the complexity of the spill that is not currently being captured. The Outreach, in collaboration, will relate environmental health education that applies to the Gulf of Mexico Oil Spill research of the Project and disseminate to individuals working and living in the states along the coastline of the Gulf of Mexico using novel methods including the web. PUBLIC HEALTH RELEVANCE: Rapid generation of high throughput bioavailable PAHs data in air and water from the Deepwater Horizon Spill in LA, MS, AL, and FL will have standalone value. First creation of bioavailable oxygenated PAH data will be invaluable to understanding effects on environmental and human health. Providing pertinent PAH health information to be delivered using novel methods via the web will fill identified information gaps needed by community leaders, and public health professionals.

描述（由申请人提供）：拟议项目的目标是在 2010 年深水地平线泄漏事故发生之前、期间和之后在墨西哥湾使用被动采样器。被动采样器是用于测量环境压力源的生物反应指示装置（BRIDGES）是作为超级基金中心赠款的一部分开发的。这些设备是空气和水被动采样设备 (PSD)，可连接环境暴露和生物反应/效应。它们可以提供高通量样品和快速数据周转。它们可以隔离多环芳烃 (PAH)、含氧多环芳烃 (OPAH) 以及其他有机污染物。 OPAH 可能比 PAH 更具流动性、生物利用度和/或持久性。越来越多的证据表明 OPAH 具有重要的毒理学意义。增加生物利用度的分散剂加上暴露于紫外线的部位可能会增加 OPAHs。使用补充生物分析工具来量化 PAH 过程的生物利用度对于了解化学品泄漏风险等灾难非常重要。具体目标 1：在影响之前、期间和之后在墨西哥湾区域部署一套桥梁、空气和水生物分析工具，以定量隔离生物可利用的污染物。具体目标 2：对 PSD 提取物和污染物源类型中的成分进行区分模式识别和多元回归评估。具体目标 3：利用斑马鱼发育模型和 Ames 试验来测试深水地平线溢油 BRIDGES 提取物在影响前、影响期间和影响后的相对效力。从转化的角度来看，目前含氧多环芳烃和风险评估流程方面存在显着的数据差距，目前 EPA 只关注空气中 16 种优先的多环芳烃。众所周知，OPAH 是一种重要的危害，检测和量化将为目前尚未捕获的泄漏的复杂性提供新的、非常重要的信息。外展活动将与该项目合作，将适用于墨西哥湾漏油研究的环境健康教育联系起来，并使用包括网络在内的新颖方法向在墨西哥湾沿岸各州工作和生活的个人进行传播。 公共健康相关性：快速生成洛杉矶、密西西比州、阿拉巴马州和佛罗里达州深水地平线泄漏事件中空气和水中的高通量生物可利用多环芳烃数据将具有独立价值。首次创建生物可利用的含氧多环芳烃数据对于了解对环境和人类健康的影响具有不可估量的价值。通过网络使用新颖的方法提供相关的多环芳烃健康信息将填补社区领导和公共卫生专业人员所需的已知信息空白。