Environmental Exposures & Sleep in the Nurses' Health Study 3

环境暴露

• 批准号: 10677271
• 负责人: Cindy Robin Hu
• 金额: $ 4.54万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677271
• 关键词: 18 year old; Accelerometer; Address; Adult; Affect; Agreement; Air Pollution; Anxiety; Arts; Behavior; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Chronic; Cognition; Complex; Development; Diabetes Mellitus; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Exposure to; Fellowship; Female; Future; Geographic Distribution; Geography; Goals; Gold Alloys; Green space; Health; Health Status; Health Technology; Health behavior; Hour; Human; Humidity; Individual; Investigation; Joints; Light; Link; Location; Longitudinal cohort; Maintenance; Measurement; Measures; Mediating; Mediation; Mental Depression; Mental Health; Mentorship; Metabolic; Neighborhoods; Nurses; Nurses' Health Study; Nursing Students; Obesity; Outcome; Pathway interactions; Patient Self-Report; Performance; Physical activity; Physiological; Polysomnography; Population; Positioning Attribute; Process; Prospective cohort; Public Health Schools; Recommendation; Recording of previous events; Recovery; Reporting; Research; Resources; Risk; Risk Factors; Role; Science; Seasons; Shapes; Sleep; Sleep Deprivation; Socioeconomic Status; Source; Temperature; Time; Training; United States; Universities; Validation; Woman; Wrist; actigraphy; built environment; cohort; doctoral student; epidemiology study; experience; fitbit; graduate school; health data; health determinants; insight; interest; mHealth; male; men; physical conditioning; population health; pre-doctoral; public health intervention; repaired; sleep health; smartphone application; social; tool; walkability; wearable device

PROJECT SUMMARY The goal of this F31 fellowship application is to support and promote the training of Cindy R. Hu, currently a pre-doctoral student in the Department of Environmental Health of the Harvard TH Chan School of Public Health and the Graduate School of Arts and Sciences at Harvard University. Her long-term research interests focus on the associations of multiple environmental exposures on sleep. Ms. Hu has assembled a group of leading experts as her Sponsors and Co-Sponsors including Drs. Jaime Hart, Brent Coull, Peter James, and Susan Redline. Sleep is an important component of human health; it is a process that serves key functions in cognition, performance, physiological repair, and recovery. Inadequate sleep has been linked to many physical health outcomes like cardiovascular disease, diabetes, and obesity, as well as mental health outcomes such as anxiety and depression. A nation-wide analysis showed an uneven geographic distribution of insufficient sleep across the US; this geographic variability may be explained by a confluence of social and environmental determinants of health. Environmental exposures that shape one’s sleeping environment as well as exposures that are experienced during wake can impact sleep health. Of particular interest due to their modifiability are built environment factors, such as light at night, neighborhood greenspace, and walkability have been shown to affect sleep. Currently, environmental epidemiological studies of sleep often rely on self-reported measures of sleep. The development of mobile health technologies provides an opportunity to quantitatively measure sleep in ecologically valid and free-living (i.e. non-laboratory) conditions on a larger scale, but requires validation against research standards. In addition to quantitative assessments of sleep, mobile health data can provide rich information on GPS location and behaviors like physical activity, which allow for investigation of mechanisms that link environmental exposures to sleep. Another key aspect of furthering our understanding of how the environment impacts sleep is the utilization of an exposomic framework; to our knowledge, no study has examined the effects of multiple exposures on sleep. Using the unique resources of the Nurses’ Health Study 3 (NHS3) longitudinal cohort, Ms. Hu will receive extensive training in multiple aspects of exploring the impacts of the environment on sleep, ranging from how to compare objective measures from multiple sources (Aim 1), using mobile health panel studies to examine associations between features of the built environment on sleep outcomes (Aim 2), and how to scale these insights to a full cohort of US women and men (Aim 3). This will position her to be a future leader in the field of the environment and sleep through high-quality mentorship and extensive professional development opportunities.

项目概要 F31 奖学金申请的目标是支持和促进 Cindy R. Hu 的培训，她目前是一名 哈佛大学陈曾熙公共卫生学院环境健康系博士生 她的长期研究兴趣集中在哈佛大学艺术与科学研究生院。 胡女士组建了一组领先的睡眠环境暴露协会。 专家作为她的发起人和共同发起人，包括 Jaime Hart、Brent Coull、Peter James 和 Susan 博士。 红线。睡眠是人类健康的重要组成部分；它是一个在认知、 睡眠不足与许多身体健康有关。 心血管疾病、糖尿病和肥胖等结果，以及焦虑等心理健康结果 一项全国范围的分析显示，睡眠不足的地理分布不均匀。 美国；这种地理差异可能是由社会和环境决定因素的共同作用来解释的 影响健康的环境暴露以及影响睡眠环境的暴露。 由于其可修改性，醒来期间经历的经历会影响睡眠健康，因此特别令人感兴趣。 环境因素，例如夜间光线、社区绿地和步行便利性已被证明 目前，睡眠的环境流行病学研究通常依赖于自我报告的测量方法。 移动健康技术的发展为定量测量睡眠提供了机会。 在更大规模的生态有效和自由生活（即非实验室）条件下，但需要验证 除了睡眠的定量评估之外，移动健康数据还可以提供根据研究标准的数据。 有关 GPS 位置和身体活动等行为的丰富信息，可用于调查 将环境暴露与睡眠联系起来的机制是加深我们对睡眠的理解的另一个关键方面。 据我们所知，环境如何影响睡眠是利用暴露组，没有研究； 利用护士健康中心的独特资源研究了多次暴露对睡眠的影响。 研究3（NHS3）纵向队列中，胡女士将接受多方面的广泛培训，探索 环境对睡眠的影响，包括如何比较多个来源的客观测量值 （目标 1），使用移动健康小组研究来检查建筑环境特征之间的关联 睡眠结果（目标 2），以及如何将这些见解推广到整个美国女性和男性群体（目标 3）。 将使她成为环境领域的未来领导者，并通过高质量的指导来睡眠 以及广泛的专业发展机会。