BRIDGES for Evaluation of Health Outcomes, Repercussions and Impacts in Zones of

评估健康结果、后果和影响的桥梁

• 批准号: 8195395
• 负责人: Kim A. Anderson
• 金额: $ 10.97万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-11-22 至 2012-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195395
• 关键词: Address; Affect; Air; Ames Assay; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Assay; Biological Availability; Chemicals; Collaborations; Communities; Coupled; Data; Detection; Development; Devices; Diagnostic; Disasters; Embryo; Environmental Exposure; Environmental Health; Evaluation; Exposure to; Fingerprint; Florida; Generations; Goals; Grant; Health; Health Professional; Health education; Human; In Situ; Individual; Internet; Life; Louisiana; Measurement; Measures; Methods; Mexico; Modeling; Oils; Online Systems; Outcome; Pattern Recognition; Process; Public Health; Reaction; Relative (related person); Research Project Grants; Risk; Risk Assessment; Sampling; Site; Source; Superfund; System; Technology; Testing; Time; Toxic effect; Uncertainty; Water; Work; Zebrafish; abstracting; analytical tool; chemical spill; environmental stressor; hazard; innovation; microbial; novel; organic contaminant; outreach; response; tool; zebrafish development

Abstract The goals of the proposed project will be to use passive samplers in the Gulf of Mexico before, during and post impact from the Deepwater Horizon Spill of 2010. The passive samplers are biological response indicator devices for gauging environmental stressors (BRIDGES) developed as part of a Superfund Center grant. The devices are air and water passive sampling devices (PSD) that bridge environmental exposure and biological response/effect. They can provide for high throughput samples and rapid turnaround of data. They sequester polycyclic aromatic hydrocarbons (PAHs), oxygenated PAHs (OPAHs) as well as other organic contaminants. OPAHs are potentially more mobile, bioavailable and/or persistent than PAHs. There is growing evidence that OPAHs have important toxicological significance. Dispersants that increase bioavailability coupled with sites exposed to UV may increase OPAHs. The use of complementary bioanalytical tools that quantify bioavailability PAH processes is important to understand disasters such as chemical spill risk. Specific Aim 1: Deploy a set of BRIDGES, air and water bio-analytical tools, regionally in the Gulf of Mexico before, during and post impact to quantitatively sequester bioavailable contaminants. Specific Aim 2: Develop discriminatory pattern recognition and multivariate regression assessments of components in PSD extracts and contaminant source type. Specific Aim 3: Utilize the zebrafish developmental model and Ames assay to test the relative potency of pre-, during and post-impact Deepwater Horizon spill BRIDGES extracts. From a translational perspective, a significant data gap currently exists with respect to oxygenated PAHs and the risk assessment process, currently only the 16 priority PAHs in air is EPA's focus. OPAHs are known to be important hazards, the detection and quantification will provide new and very important information on the complexity of the spill that is not currently being captured. The Outreach, in collaboration, will relate environmental health education that applies to the Gulf of Mexico Oil Spill research of the Project and disseminate to individuals working and living in the states along the coastline of the Gulf of Mexico using novel methods including the web.

抽象的 拟议项目的目标是之前在墨西哥湾使用被动采样器， 2010 年深水地平线泄漏事件期间和之后的影响。被动采样器是 用于测量环境压力源的生物反应指示装置（BRIDGES） 作为超级基金中心赠款的一部分开发。该设备为空气和水被动采样 连接环境暴露和生物反应/效应的设备（PSD）。他们可以 提供高通量样品和数据的快速周转。它们隔离多环 芳香烃 (PAH)、含氧多环芳烃 (OPAH) 以及其他有机化合物 污染物。 OPAH 可能比 PAH 更具流动性、生物利用度和/或持久性。 越来越多的证据表明 OPAH 具有重要的毒理学意义。分散剂 增加生物利用度以及暴露于紫外线的部位可能会增加 OPAH。使用 量化 PAH 过程生物利用度的补充生物分析工具对于 了解化学品泄漏风险等灾难。具体目标 1：部署一组桥梁、空中桥梁 和水生物分析工具，在墨西哥湾地区的影响之前、期间和之后 定量隔离生物可利用的污染物。具体目标 2：制定歧视性政策 PSD 提取物中成分的模式识别和多元回归评估 和污染源类型。具体目标 3：利用斑马鱼发育模型和 艾姆斯测定法测试深水地平线泄漏事件发生前、发生期间和发生后的相对效力 桥梁摘录。从转化的角度来看，目前存在显着的数据差距 关于含氧多环芳烃和风险评估流程，目前只有 16 个优先事项 空气中的多环芳烃是 EPA 关注的焦点。众所周知，OPAH 是一种重要的危害，检测和 量化将提供有关泄漏复杂性的新的、非常重要的信息， 目前尚未被捕获。通过合作，外展活动将涉及环境健康 适用于墨西哥湾漏油项目研究的教育并传播至 在墨西哥湾沿岸各州工作和生活的个人使用小说 方法包括网络。