Core D: Research Support (Anderson)

核心 D：研究支持（安德森）

• 批准号: 8695376
• 负责人: Kim A. Anderson
• 金额: $ 32.41万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695376
• 关键词: Adoption; Analytical Chemistry; Anus; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Markers; Chemicals; Chemistry; Collaborations; Collection; Communities; Complex; Data; Data Set; Development; Devices; Environment; Evaluation; Feedback; Genome; Health; Instruction; Investigation; Isomerism; Laboratories; Methods; Online Systems; Recording of previous events; Relative (related person); Research; Research Personnel; Research Support; Risk; Sampling; Signal Recognition Particle; Superfund; System; Techniques; Testing; Work; analytical method; analytical tool; base; chemical standard; method development; molecular mass; new technology; programs; remediation; repository; screening

PROJECT SUMMARY (See instructions): The research and regulatory communities acknowledge the need to develop analytical methods for PAHs and substitute PAHs (x-PAHs). The recent US EPA IRIS 2010 document Development of a Relative Potency Factory (RFP) Approach for Polycyclic Aromatic Hydrocarbon Mixtures says, "While whole mixture assessment is preferred . . . chemical analysis of the components of mixtures is limited . . . The RPF approach is limited by the small number of PAHs for which there are analytical chemistry." It is challenging to analyze PAHs and x-PAHs in environmental and biological matrices because the samples are complex, the numerous isomers of alkylated and high-molecular-mass compounds are often difficult to differentiate, and we often lack standards and suitable reference materials. We will provide rapid chemical screening and quantitative analysis of mixtures from applicable matrices. The Chemistry Core provides Superfund Center Investigators with critical specialized analytical expertise. We will develop advanced techniques and methods for PAHs and mixtures. The need for new analytical methods continues to top the list of data gaps cited by agency workgroups. We need to further develop our 1,201 analyte screening method to "know thy environment" paralling the genome "know thyself technical advances. We will continue to develop a synthesis unit to make chemical standards that are not commercially available. We enable the work of our biomedical projects by synthesizing PAH metabolites. We plan to expand our synthesis component to include PAHs and substituted PAHs that are not currently commercially available. The lack of commercial standards constitutes a critical barrier to analytical method development and subsequent biomedical testing. We will continue to develop a centralized repository for exposure-based mixture reference materials, standards, and passive sampling devices. We propose to develop new Superfund reference materials, including bioavailable Superfund based materials and pre-and post-remediation extracts. We will make these well-characterized mixtures available to SRP investigators. We will also prepare and distribute passive sampling devices to SRP investigators and US EPA project managers for pilot investigations and evaluation.

项目摘要（参见说明）： 研究和监管界承认需要开发多环芳烃和替代多环芳烃 (x-PAH) 的分析方法。最近的美国 EPA IRIS 2010 文件《开发多环芳烃混合物的相对效力工厂 (RFP) 方法》指出，“虽然首选整个混合物评估……混合物成分的化学分析有限……RPF 方法是受到分析化学中多环芳烃数量较少的限制。”分析环境和生物基质中的 PAH 和 x-PAH 具有挑战性，因为样品很复杂，烷基化和高分子质量化合物的众多异构体通常难以区分，而且我们经常缺乏标准和合适的参考材料。我们将对适用基质中的混合物进行快速化学筛选和定量分析。化学核心为超级基金中心研究人员提供关键的专业分析专业知识。我们将开发针对多环芳烃和混合物的先进技术和方法。对新分析方法的需求仍然是机构工作组列出的数据缺口的首要问题。我们需要进一步开发我们的 1,201 种分析物筛选方法，以“了解你的环境”，与基因组“了解你自己”的技术进步并行。我们将继续开发合成装置，以制定尚未商业化的化学标准品。我们使我们的生物医学工作得以开展我们计划扩大我们的合成成分，以包括目前尚未商业化的多环芳烃和替代多环芳烃。商业标准的缺乏构成了分析方法开发和后续的关键障碍。我们将继续开发基于暴露的混合物参考材料、标准品和被动采样设备的集中存储库，我们建议开发新的 Superfund 参考材料，包括基于生物可利用的 Superfund 材料和修复前和修复后提取物。我们还将向 SRP 研究人员和美国 EPA 项目经理准备和分发被动采样设备，以进行试点调查和评估。