Non-invasive optical detection of cerebral hemodynamics and metabolic transients

脑血流动力学和代谢瞬态的无创光学检测

• 批准号: 9185520
• 负责人: SERGIO FANTINI
• 金额: $ 21.23万
• 依托单位: TUFTS UNIVERSITY MEDFORD
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9185520
• 关键词: Accounting; Assessment tool; Biological; Blood; Blood capillaries; Blood flow; Boa; Brain; Brain imaging; Calibration; Cardiovascular system; Cell Respiration; Cerebrovascular Circulation; Cerebrum; Complement; Conscious; Critical Care; Data; Data Analyses; Detection; Development; Diagnosis; Diffuse; Disease; Functional Imaging; Functional Magnetic Resonance Imaging; Hemoglobin; Human; Imaging Techniques; Individual; Lead; Maps; Measurement; Measures; Metabolic; Methods; Modeling; Near-Infrared Spectroscopy; Neurologic; Optical Methods; Optics; Oxygen; Oxygen Consumption; Pain; Pain Measurement; Patients; Perfusion; Physiological; Pike fish; Process; Research; Resolution; Rest; Signal Transduction; Spectrum Analysis; Spin Labels; Stimulus; Structure; Techniques; Testing; Time; Tissues; Translating; Venous; Yang; base; blood oxygen level dependent; capillary; cerebral blood volume; cerebral hemodynamics; clinical application; data modeling; follow-up; hemodynamics; hemoglobin D; human subject; innovation; interest; metabolic rate; millisecond; nervous system disorder; neuroimaging; neurovascular; novel; optical imaging; pressure; public health relevance; response; tool

Project Summary: This project aims to demonstrate the feasibility of non-invasive optical measurements of the dynamic time courses of hemodynamic and metabolic changes associated with brain activation, systemic changes in mean arterial pressure, and spontaneous hemodynamic oscillations in human subjects. Functional near-infrared spectroscopy (fNIRS) is a non-invasive optical technique that measures the cerebral concentrations of oxy-hemoglobin (O) and deoxy-hemoglobin (D). The biological origin of O and D changes includes hemodynamic changes described by cerebral blood volume (CBV) and cerebral blood flow (CBF), and metabolic changes described by the cerebral metabolic rate of oxygen (CMRO2). We have recently introduced a novel hemodynamic model that translates dynamic changes in CBV, CBF, and CMRO2 into O and D changes that are measured by fNIRS. It is a multi-compartment model that takes into account the dynamic effects associated with capillary and venous blood transit times. Because our model predicts that fNIRS signals depend on the difference of CBF and CMRO2 changes, we propose to complement fNIRS with measurements of CBF with diffuse correlation spectroscopy (DCS), which is also a non-invasive optical technique. We propose to perform the analysis of concurrent and co-localized fNIRS and DCS data with our new hemodynamic model to generate dynamic traces of CBV, CBF, and CMRO2 that describe hemodynamic and metabolic transients and fluctuations. This is an innovative approach with respect to current methods in the fields of functional MRI and optical imaging that are commonly based on steady state models, which are intrinsically inadequate for the study of transient conditions. We also hypothesize that a universal dynamic relationship between optically measured CBV and CBF can be identified to allow for dynamic measurements of CBV, CBF, and CMRO2 with stand-alone fNIRS. We will perform human studies to demonstrate the feasibility of the proposed methods to characterize brain activation, controlled perturbations to the mean arterial pressure, and spontaneous hemodynamic oscillations at rest. This project will result in the development of a powerful optical tool for the functional study of the human brain to characterize brain activation conditions and resting state functional connectivity. Such a tool can significantly impact functional neuroimaging research and find clinical applications in the diagnosis and assessment of neurovascular disorders.

项目摘要：该项目旨在证明非侵入性光学测量的可行性 与大脑激活相关的血液动力学和代谢变化的动态时间课程 人类受试者中平均动脉压的变化和自发性血流动力学振荡。功能 近红外光谱法（FNIRS）是一种无创的光学技术，可测量大脑 氧血红蛋白（O）和脱氧血红蛋白（D）的浓度。 O和D的生物学起源 包括由脑血容量（CBV）和脑血流（CBF）描述的血液动力学变化，以及 氧脑代谢率描述的代谢变化（CMRO2）。我们最近介绍了 一种新型的血液动力学模型，将CBV，CBF和CMRO2的动态变化转化为O和D 通过FNIRS测量的变化。这是一个多室模型，它考虑了动态 与毛细血管和静脉血液过渡时间相关的影响。因为我们的模型预测FNIRS信号 取决于CBF和CMRO2变化的差异，我们建议与测量相辅相成 具有分散相关光谱（DC）的CBF的CBF，这也是一种非侵入性光学技术。我们 提议与我们的新数据对并发和共定位的FNIRS和DCS数据进行分析 血液动力学模型以生成CBV，CBF和CMRO2的动态痕迹，以描述血液动力学和 代谢瞬变和波动。这是关于当前方法的创新方法 通常基于稳态模型的功能性MRI和光学成像领域 本质上不足以研究瞬态条件。我们还假设是通用的动态 可以确定光学测量的CBV和CBF之间的关系，以允许动态测量 CBV，CBF和CMRO2具有独立的FNIRS。我们将进行人类研究以证明可行性 提出的表征大脑激活的方法，控制平均动脉压的扰动 和静止时自发性血流动力学振荡。该项目将导致一个强大的发展 人脑功能研究的光学工具以表征脑激活条件和静止 状态功能连接。这样的工具可以显着影响功能性神经影像学研究，并发现 神经血管疾病的诊断和评估中的临床应用。