Near-infrared spectral imaging of the breast for cancer detection and monitoring

用于癌症检测和监测的乳腺近红外光谱成像

• 批准号: 8191273
• 负责人: SERGIO FANTINI
• 金额: $ 46.44万
• 依托单位: TUFTS UNIVERSITY MEDFORD
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-12 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8191273
• 关键词: Area; Benign; Breast; Breast Cancer Detection; Cancer Detection; Cancer Diagnostics; Clinical; Collection; Data; Detection; Development; Discrimination; Effectiveness; Engineering; Female breast; Hemoglobin; Human; Image; Lesion; Light; Lipids; Malignant - descriptor; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Neoplasms; Mammography; Maps; Medical center; Methods; Monitor; Neoadjuvant Therapy; Optical Instrument; Optics; Outcomes Research; Oxygen saturation measurement; Pattern; Phase; Reproducibility; Research; Research Activity; Resolution; Sampling; Scanning; Scheme; Spatial Distribution; Testing; Time; Tissues; Treatment Efficacy; Water; Work; analytical tool; base; breast lesion; cancer regression; cancer therapy; chromophore; clinical application; clinical practice; design; hemodynamics; image reconstruction; imaging modality; in vivo; instrument; instrumentation; interest; malignant breast neoplasm; novel; optical imaging; prototype; reconstruction; research and development; response; tool; tumor progression

DESCRIPTION (provided by applicant): This project involves (1) the development of a novel instrument for optical imaging of the human breast, and (2) pilot clinical tests to demonstrate the effectiveness of the proposed instrument in detecting breast cancer and monitoring response to neoadjuvant therapy of breast cancer. The proposed instrument features levels of spatial sampling (25 points/cm2 on the x-y scanning plane), spectral sampling (0.5 points/nm over the wavelength band 650-1000 nm), and temporal resolution (20 full spectra/s) that are not simultaneously achieved by any existing optical mammography instrument. These instrumentation capabilities will be used to enhance the information content of optical mammograms in terms of spatial information (depth discrimination, tomographic reconstruction of hemoglobin/water/lipid/scattering-parameters distributions), quantitative oximetry, and temporal hemodynamics characterization. The planned clinical tests will specifically test the hypothesis that intrinsic optical contrast provided by hemoglobin, water, lipids, and scattering parameters in breast tissue allows for the detection of breast cancer, its discrimination from benign breast lesions, and for monitoring effectiveness of neoadjuvant breast cancer therapy. The broad objective of this application is the development of optical mammography as a stand-alone clinical tool for breast cancer detection, and for monitoring effectiveness of therapy. PUBLIC HEALTH RELEVANCE: This research can open new opportunities for clinical practice in the areas of breast cancer detection and prediction of response to treatment. In fact, the proposed instrument for optical imaging of the breast provides functional information (hemodynamics, oxygenation, water/lipids distribution, etc.) that is complementary to the information provided by existing clinical imaging modalities, thus potentially enhancing detection of breast cancer and its discrimination from benign lesions. Furthermore, because the proposed instrument uses safe levels of non-ionizing near-infrared light, it allows for repeated breast examinations on a weekly or even daily basis for continuous monitoring of breast cancer progression or regression.

描述（由申请人提供）：该项目涉及（1）开发一种新型的人类乳房光学成像的仪器，以及（2）试验临床测试，以证明该拟议仪器在检测乳腺癌和监测对乳腺癌新辅助治疗的反应中的有效性。所提出的仪器具有空间采样的水平（X-Y扫描平面上的25点/cm2），光谱采样（在波长650-1000 nm上的0.5点/nm）和时间分辨率（20个完整光谱/s），这些分辨率并非通过任何现有的光学乳液仪器同时实现。这些仪器功能将用于增强光学乳房X线照片的信息含量（在空间信息，血红蛋白/水/脂质/脂质/散射参数分布），定量血氧仪和临时血液动力学特征方面的空间信息（深度歧视，层析成像重建）。计划的临床测试将特异性检验以下假设：乳腺组织中血红蛋白，水，脂质和散射参数提供的内在光学对比度可以检测乳腺癌，其与良性乳腺癌的歧视以及监测新辅助乳腺癌治疗的有效性。该应用的广泛目的是将光X线摄影作为乳腺癌检测的独立临床工具的发展，并用于监测治疗的有效性。 公共卫生相关性：这项研究可以在乳腺癌检测和对治疗反应的预测领域开辟新的临床实践机会。实际上，乳房光学成像的拟议仪器提供了功能信息（血液动力学，氧合，水/脂质分布等），符合现有的临床成像方式提供的信息，从而有可能增强乳腺癌的检测及其对良性病情的歧视。此外，由于所提出的仪器使用安全水平的非电离近红外光，因此它可以每周甚至每天进行一次重复的乳房检查，以连续监测乳腺癌的进展或退化。