Near-infrared spectral imaging of the breast for cancer detection and monitoring

用于癌症检测和监测的乳腺近红外光谱成像

基本信息

批准号：
8300116
负责人：
SERGIO FANTINI
金额：
$ 46.44万
依托单位：
TUFTS UNIVERSITY MEDFORD
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-12 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8300116
关键词：
Area Benign Breast Breast Cancer Detection Cancer Detection Cancer Diagnostics Clinical Collection Data Detection Development Discrimination Effectiveness Engineering Female breast Hemoglobin Human Image Lesion Light Lipids Malignant - descriptor Malignant Neoplasms Mammary Gland Parenchyma Mammary Neoplasms Mammography Maps Medical center Methods Monitor Neoadjuvant Therapy Optical Instrument Optics Outcomes Research Oxygen saturation measurement Pattern Phase Reproducibility Research Research Activity Resolution Sampling Scanning Scheme Spatial Distribution Testing Time Tissues Treatment Efficacy Water Work analytical tool base breast lesion cancer regression cancer therapy chromophore clinical application clinical practice design hemodynamics image reconstruction imaging modality in vivo instrument instrumentation interest malignant breast neoplasm novel optical imaging prototype reconstruction research and development response tool tumor progression

项目摘要

DESCRIPTION (provided by applicant): This project involves (1) the development of a novel instrument for optical imaging of the human breast, and (2) pilot clinical tests to demonstrate the effectiveness of the proposed instrument in detecting breast cancer and monitoring response to neoadjuvant therapy of breast cancer. The proposed instrument features levels of spatial sampling (25 points/cm2 on the x-y scanning plane), spectral sampling (0.5 points/nm over the wavelength band 650-1000 nm), and temporal resolution (20 full spectra/s) that are not simultaneously achieved by any existing optical mammography instrument. These instrumentation capabilities will be used to enhance the information content of optical mammograms in terms of spatial information (depth discrimination, tomographic reconstruction of hemoglobin/water/lipid/scattering-parameters distributions), quantitative oximetry, and temporal hemodynamics characterization. The planned clinical tests will specifically test the hypothesis that intrinsic optical contrast provided by hemoglobin, water, lipids, and scattering parameters in breast tissue allows for the detection of breast cancer, its discrimination from benign breast lesions, and for monitoring effectiveness of neoadjuvant breast cancer therapy. The broad objective of this application is the development of optical mammography as a stand-alone clinical tool for breast cancer detection, and for monitoring effectiveness of therapy.

描述（由申请人提供）：该项目涉及 (1) 开发一种用于人类乳房光学成像的新型仪器，以及 (2) 试点临床测试，以证明所提出的仪器在检测乳腺癌和监测对乳腺癌的反应方面的有效性。乳腺癌新辅助治疗。所提出的仪器具有空间采样水平（x-y 扫描平面上 25 点/cm2）、光谱采样（650-1000 nm 波长带上 0.5 点/nm）和时间分辨率（20 个全光谱/秒），任何现有的光学乳腺X线摄影仪器均可同时实现。这些仪器功能将用于增强光学乳房 X 光检查在空间信息（深度辨别、血红蛋白/水/脂质/散射参数分布的断层扫描重建）、定量血氧测定和时间血流动力学表征方面的信息内容。计划中的临床测试将专门测试以下假设：乳腺组织中的血红蛋白、水、脂质和散射参数提供的内在光学对比度可以检测乳腺癌、区分良性乳腺病变，并监测新辅助乳腺癌的有效性治疗。该应用的主要目标是开发光学乳房X线照相术作为乳腺癌检测和监测治疗效果的独立临床工具。