Near-infrared oximetry of breast tumors

乳腺肿瘤的近红外血氧定量法

• 批准号: 7390343
• 负责人: SERGIO FANTINI
• 金额: $ 33.1万
• 依托单位: TUFTS UNIVERSITY MEDFORD
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-21 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7390343
• 关键词: Area; Benign; Breast; Breast Cancer Detection; Collection; Data Analyses; Depth; Detection; Discrimination; Effectiveness; Functional Imaging; Hemoglobin; Image; Imaging Techniques; Lighting; Malignant - descriptor; Mammary Neoplasms; Mammography; Measurement; Measures; Methods; Nature; Optical Instrument; Optics; Oxygen saturation measurement; Painless; Performance; Phase; Pilot Projects; Safety; Scanning; Scheme; Sensitivity and Specificity; Shapes; Simulate; Testing; Tumor Oxygenation; Work; base; breast lesion; human subject; improved; instrument; malignant breast neoplasm; novel; optical fiber; size; success; tool; transmission process; tumor; two-dimensional

DESCRIPTION (provided by applicant): Near-infrared mammography is a safe and painless breast imaging technique that is inherently sensitive to the hemoglobin concentration and oxygenation within the breast. The potential of this functional imaging technique for the detection of breast cancer has been explored for many decades with only partial success. The major limitation has been the qualitative nature of the oxygenation information provided by previous approaches to optical mammography. The broad objective of this application is to develop a new optical tool for functional breast imaging, which is aimed at discriminating benign and malignant breast lesions on the basis of a quantitative measurement of their oxygenation level. In the R21 Phase of this proposal, we intend to experimentally demonstrate the feasibility and the potential effectiveness of a novel spectral approach to optical mammography. To this aim, we plan to perform experimental tests on breast-like phantoms to simulate a quantitative measurement of the oxygen saturation of hemoglobin within breast lesions. The proposed approach is based on our quest for a robust oxygenation measurement of breast tumors that is insensitive to the high variability in the shape, size, and depth of the tumors. The basic hypothesis behind this proposal is that optical measurements at two optimal wavelengths, which are identified within the 680- 880 nm spectral band using a novel scheme of data analysis, can provide an accurate measurement of the tumor oxygenation. In the R33 Phase, we will implement the proposed spectral method into a practical instrument for breast imaging that is applicable to human subjects. This instrument will work in an optical transmission mode through the slightly compressed breast, and will measure two-dimensional projection images of the breast by means of a planar tandem scan of the illumination and collection optical fibers. Following preliminary tests of safety and technical performance, we will carry out a pilot study on human subjects to investigate the practical effectiveness of our proposed spectral approach. In particular, we will assess its potential in the detection and discrimination of benign and malignant breast tumors on the basis of their oxygenation levels. Our proposed approach to optical mammography has the potential to improve both the specificity and the sensitivity of current optical instruments, and it may open new opportunities in the area of breast cancer detection.

描述（由申请人提供）： 近红外乳腺X线摄影是一种安全且无痛的乳房成像技术，对乳房内的血红蛋白浓度和氧合固有敏感。数十年来，已经探索了这种功能成像技术检测乳腺癌的潜力。主要的局限性是先前的光X摄影方法提供的氧合信息的定性性质。该应用的广泛目的是开发一种用于功能性乳房成像的新光学工具，该工具旨在根据其氧合水平的定量测量，旨在区分良性和恶性乳房病变。在该提案的R21阶段，我们打算在实验上证明新型光X线摄影的新光谱方法的可行性和潜在有效性。为此，我们计划对乳腺样幻象进行实验测试，以模拟乳腺病变中血红蛋白氧饱和度的定量测量。所提出的方法是基于我们对乳腺肿瘤进行稳健的氧合测量的寻求，这对肿瘤的形状，大小和深度的高变异性不敏感。该提案背后的基本假设是，使用新的数据分析方案在680-880 nm光谱带中鉴定出两个最佳波长的光学测量值可以提供对肿瘤氧合的准确测量。在R33阶段，我们将将所提出的光谱方法实施到适用于人类受试者的乳房成像的实用仪器中。该仪器将通过略微压缩的乳房在光学传输模式下工作，并通过平面串联扫描和收集光纤维的平面串联扫描来测量乳房的二维投影图像。经过对安全性和技术绩效的初步测试，我们将对人类受试者进行一项试点研究，以研究我们提出的光谱方法的实际有效性。特别是，我们将根据其氧合水平评估其在良性和恶性乳腺肿瘤的检测和区分中的潜力。我们提出的光乳房X线摄影方法具有提高当前光学仪器的特异性和敏感性的潜力，并且它可能在乳腺癌检测领域打开新的机会。