Shear Wave Reciprocity for Breast Imaging

乳房成像的剪切波互易性

• 批准号: 10722721
• 负责人: Stephen A McAleavey
• 金额: $ 19.25万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-07 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10722721
• 关键词: Acoustics; Area; Benign; Biopsy; Breast Microcalcification; Breast biopsy; Categories; Classification; Computer Models; Data; Descriptor; Development; Diagnosis; Diagnostic; Distal; Elasticity; Equipment; Focused Ultrasound; Geometry; Goals; Human; Image; Lesion; Location; Malignant - descriptor; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Ultrasonography; Maps; Mastectomy; Measurement; Measures; Mechanics; Methods; Modulus; Morphologic artifacts; Parameter Estimation; Patients; Performance; Physicians; Predictive Value; Property; Radiation; Research; Resolution; Shapes; Source; Speed; System; Testing; Tissue Sample; Tissue imaging; Tissues; Ultrasonics; Ultrasonography; Variant; Woman; absorption; acoustic imaging; attenuation; breast imaging; breast lesion; contrast imaging; design; elastography; electric impedance; imaging system; improved; in vivo; malignant breast neoplasm; parametric imaging; simulation; sound; success; transmission process; ultrasound

Abstract: We propose a new ultrasound image formation method, which we call shear-wave reciprocity imaging (SRI), to produce images based on the sound speed and attenuation of tissue. These acoustic properties carry important diagnostic information but are not revealed in conventional B-mode images except as artifacts. For example, in breast imaging the “posterior features” (shadowing/enhancement) BiRADS descriptor depends on these properties. In contrast to conventional B-mode imaging that produces speckle images of variations in tissue acoustic impedance, we propose SRI as a method for speckle-free imaging of an attenuation/sound speed parameter. SRI images are complementary to both B-mode and elastography images yet are produced using the same backscatter imaging geometry as conventional ultrasound. SRI relies on the principle of mechanical reciprocity to measure local variations in acoustic radiation force, which relate to attenuation and sound speed. While using acoustic radiation force impulses similar to ARFI imaging, SRI is designed to be insensitive to elastic properties and to specifically image the attenuation/sound speed parameter. The aims of this project are to implement SRI on a linear-array imaging system, characterize its sensitivity and resolution through in vivo measurements prior to biopsy, and validate SRI in ex vivo breast tissue from mastectomy. We expect that the additional information provided by SRI will ultimately improve lesion categorization and reduce the number of biopsies required by replacing qualitative estimates of lesion attenuation from B-mode shadowing with parametric acoustic images.

抽象的： 我们提出了一种新的超声图像形成方法，我们将其称为剪切波相互成像（SRI） 基于组织的音速和衰减的产品图像。这些声学特性携带 重要的诊断信息，但在传统的B模式图像中未揭示，除了文物外。为了 例如，在乳房成像“后验特征”（阴影/增强）Birads描述符取决于 这些属性。与传统的B模式成像相反，该成像产生了变化的斑点图像 组织声阻抗，我们提出SRI作为一种无斑点成像的方法 速度参数。 SRI图像均已完成B模式和弹性图像均已完成 使用与常规超声相同的反向散射成像几何形状。斯里依赖于 与衰减和 音速。在使用类似于ARFI成像的声学辐射力脉冲时，SRI设计为 对弹性特性不敏感，并专门为衰减/音速参数做出图像。目的 该项目是在线性阵列成像系统上实现SRI，表征其灵敏度和分辨率 通过活检之前的体内测量，并通过乳房切除术中的体内乳腺组织验证SRI。我们 预计SRI提供的其他信息最终将改善病变类别并减少 通过替换B模式病变衰减定性估计的活检数量 用参数声图像阴影。