A novel transducer clip-on device to enable accessible and functional 3D ultrasound imaging

一种新型换能器夹式装置，可实现易于使用且功能齐全的 3D 超声成像

• 批准号: 10708132
• 负责人: Pengfei Song
• 金额: $ 52.91万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708132
• 关键词: 3-Dimensional; 3D ultrasound; Ablation; Acoustics; Address; Adjuvant Chemotherapy; Adoption; Advanced Development; Anatomy; Area; Axillary lymph node group; Basic Science; Benchmarking; Benign; Biopsy; Blood; Blood flow; Breast Cancer Patient; Cardiology; Cellular Phone; Clinic; Clinical; Clinical Research; Clip; Code; Data; Dependence; Development; Devices; Diagnosis; Diagnostic; Discipline of obstetrics; Equipment; Foundations; Frequencies; Gynecology; Illinois; Image; Imaging technology; Intervention; Ionizing radiation; Malignant - descriptor; Marketing; Medical; Medical Device Designs; Motion; Neoadjuvant Therapy; Operative Surgical Procedures; Pathology; Patients; Performance; Phase; Play; Procedures; Radiology Specialty; Role; Scanning; Solid; Speed; System; Techniques; Technology; Texas; Three-Dimensional Imaging; Time; Tissues; Training; Transducers; Ultrasonic Transducer; Ultrasonography; Universities; Visualization software; Water; Work; clinical application; clinical imaging; cost; disease diagnosis; elastography; falls; handheld equipment; imaging modality; imaging study; imaging system; improved; in vivo; light weight; malignant breast neoplasm; meetings; microsensor; microsystems; non-invasive imaging; novel; portability; radiologist; superresolution imaging; technology research and development; tool; ultrasound; user-friendly; wireless communication

PROJECT SUMMARY/ABSTRACT Three-dimensional ultrasound imaging (3D-US) is an essential clinical tool for visualizing, navigating, and investigating patient anatomy and pathologies in real time in 3D. Owing to its moderate cost and lack of ionizing radiation, 3D-US plays an important role in many clinical applications for diagnosis and intervention. Despite the significant clinical value and potential, 3D-US is not a widely accessible and capable technology with its current implementations: existing 3D-US solutions are challenged by many limitations such as low imaging speed, low functionality, bulky devices that are inconvenient to use, and a high cost of designated equipment. For decades, there has been a long-standing quest for developing an accessible, functional, and user-friendly 3D-US technology. In this proposal, we will develop a new 3D-US solution (called FASTER) that uses a novel, fast-tilting microfabricated acoustic reflector to achieve high-speed and high-functionality 3D-US imaging. The acoustic reflector is water-immersible and enclosed in a clip-on device that is compact, lightweight, and low-cost. It can be easily attached to and removed from different types of ultrasound transducers to turn a conventional 2D ultrasound system into 3D. Unlike conventional 3D-US technologies (e.g., wobbler transducers and 2D matrix arrays), FASTER does not require the procurement of additional ultrasound transducers for different applications. Also, FASTER achieves a much higher imaging volume rate (up to 1000 Hz) than conventional 3D-US technologies. FASTER is compatible with most ultrasound systems on the market ranging from premium scanners to portable and handheld devices. In this proposal, we will conduct basic technology development research and carry out preliminary clinical studies to build a solid technical foundation for the FASTER 3D-US technology. In Aim 1 we will focus on developing the Phase-1 FASTER device that uses a double-axis reflector for extended range of imaging volume rate and field-of-view (FOV). We will also develop Phase-1 FASTER into a stand-alone device that does not need external equipment and communicates wirelessly with the ultrasound system. Aim 2 will focus on developing advanced imaging modes for FASTER, including 3D blood flow imaging (3D-BFI) and 3D shear wave elastography (3D-SWE). Pilot clinical studies will be conducted for both Aims 1 and 2 to facilitate the development and optimization of the FASTER device and imaging sequences. In Aim 3 we will conduct a clinical study to evaluate the performance of FASTER 3D-US in characterizing suspicious axillary lymph nodes (ALNs) for breast cancer patients undergoing clinically indicated biopsy of ALN. We will also evaluate the performance of FASTER in localizing clipped ALNs from patients undergoing neoadjuvant chemotherapy. The study aims will be carried out by a team of experts in ultrasound imaging, micro sensors and systems, medical device design, and breast cancer from the campuses of University of Illinois Urbana- Champaign, Texas A&M University, and Mayo Clinic.

项目摘要/摘要 三维超声成像（3D-US）是可视化，导航和 在3D中实时研究患者的解剖结构和病理。由于其中等成本和缺乏电离 辐射，3D-US在许多诊断和干预的临床应用中起重要作用。尽管有 临床价值和潜力很大，3D-US并不是一项广泛访问且有能力的技术 实施：现有的3D-US解决方案受到许多限制的挑战，例如低成像速度，低 功能，不方便使用的笨重设备以及指定设备的高成本。几十年来， 长期以来一直寻求开发可访问，功能和用户友好的3D-US 技术。在此提案中，我们将开发一种新的3D-US解决方案（称为更快），该解决方案使用新颖的，快速倾斜 微生物反射器以实现高速和高功能3D-US成像。声学 反射器是可易受欢迎的，并封闭在紧凑，轻巧且低成本的夹具设备中。它可以 轻松地附着并从不同类型的超声传感器上删除以转动常规2D 超声系统分为3D。与传统的3D-US技术不同（例如，Wobbler传感器和2D矩阵 阵列），更快的速度不需要为不同的应用程序采购其他超声传感器。 同样，比传统的3D-US更快地达到更高的成像量率（最高1000 Hz） 技术。更快的速度与市场上的大多数超声系统兼容，从高级 扫描仪到便携式和手持设备。在此提案中，我们将进行基本技术开发 研究并进行初步临床研究，为更快的3D-US建立坚实的技术基础 技术。在AIM 1中，我们将专注于开发使用双轴反射器的快速设备 对于扩展成像量率和视野（FOV）的扩展范围。我们还将更快地开发1阶段1 不需要外部设备并与超声无线通信的独立设备 系统。 AIM 2将集中于更快地开发高级成像模式，包括3D血流成像 （3D-BFI）和3D剪切波弹性图（3D-SWE）。将针对目标1和 2促进更快的设备和成像序列的开发和优化。在目标3中，我们将 进行临床研究，以评估3D-US在表征可疑腋生方面的性能 接受临床表明ALN活检的乳腺癌患者的淋巴结（ALNS）。我们也会 评估从接受新辅助的患者的定位剪切ALN的速度更快的表现 化学疗法。该研究的目的将由超声成像，微传感器和 伊利诺伊大学Urbana大学校园的系统，医疗设备设计和乳腺癌 - 德克萨斯州A＆M大学香槟和梅奥诊所。