Volumetric Real-Time MRI at 0.55 Tesla

0.55 特斯拉的体积实时 MRI

• 批准号: 10611241
• 负责人: Adrienne Campbell
• 金额: $ 52.56万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611241
• 关键词: 3-Dimensional; 3D ultrasound; Adult; Air; Anatomy; Arrhythmia; Basic Science; Breathing; Cardiac; Cardiac Catheterization Procedures; Cardiac Output; Cardiac ablation; Cardiovascular system; Caring; Catheterization; Catheters; Clinical; Collaborations; Data; Deposition; Detection; Development; Devices; Diagnostic Imaging; Disease; Disease Progression; Early Diagnosis; Engineering; Evaluation; Extramural Activities; Goals; Heart; Heating; Image; Imaging technology; Intervention; Ionizing radiation; Magnetic Resonance Imaging; Manuals; Methods; Modality; Monitor; Morphologic artifacts; Motion; Movement; Myocardial; National Heart, Lung, and Blood Institute; Obstructive Sleep Apnea; Organ; Outcome; Patient Care; Patients; Pattern; Performance; Physiologic pulse; Procedures; Relapsing polychondritis; Relaxation; Research; Resolution; Sampling; Scanning; Scientist; Sleep Apnea Syndromes; Slice; Surface; System; Techniques; Technology; Testing; Time; Tissues; Trachea; Training; Translating; Ultrasonography; United States National Institutes of Health; Variant; Visualization; Work; X-Ray Computed Tomography; clinical center; clinical translation; cohort; data acquisition; deep learning; flexibility; heart function; heart imaging; image reconstruction; imaging approach; imaging modality; improved; innovation; instrument; lung imaging; magnetic field; millisecond; next generation; novel; programs; prospective test; radio frequency; real-time images; reconstruction; respiratory imaging; simulation; soft tissue; spatiotemporal; synergism; temporal measurement; ultrasound; volunteer

PROJECT SUMMARY This project will develop volumetric real-time magnetic resonance imaging (RT-MRI) technology on a novel 0.55 Tesla platform to provide improved assessment of the heart and airway in motion. Rationale: Volumetric real- time imaging by computed tomography and ultrasound have had a profound impact on our ability to understand and evaluate disorders involving movement and of moving organs. These modalities each have limitations that include ionizing radiation, obstructed visualization angles, and limited contrast. MRI is currently capable of slice- by-slice RT-MRI and a leap to volumetric would enable improved assessment of a wide range of heart and airway disorders. Innovation: NIH has developed a 0.55 Tesla MRI instrument, that we argue will enable a breakthrough in RT-MRI performance. This is due to substantially reduced off-resonance effects, substantially reduced tissue heating, and a leap in scan efficiency due to increased flexibility in the MRI pulse sequence. We propose an innovative intramural-extramural partnership and interdisciplinary team to explore this potential. Approach: The objective of this project is to develop and translate low-latency volumetric RT-MRI methods that provide unprecedented spatio-temporal resolution and spatial coverage and will benefit several heart and airway applications. Specifically, we will: 1- develop and technically validate volumetric RT-MRI data acquisition at the 0.55T field strength, 2- develop and technically validate low-latency volumetric RT-MRI reconstruction, artifact mitigation, and segmentation, and 3- clinically evaluate volumetric RT-MRI in two unique patient cohorts at the NIH Clinical Center where it is likely to make an immediate impact on care—patients with tracheomalacia and relapsing polychondritis (N=20), and patients undergoing MRI-guided invasive cardiac catheterization (N=20). Broader Impact: The proposed volumetric RT-MRI technology is generalizable and could benefit many additional applications, such as cardiac function assessment in arrhythmia, and upper airway assessment in obstructive sleep apnea. The intramural and extramural labs each offer unique and complementary expertise to achieve this ambitious technical development. Creation of this new intramural-extramural collaboration will benefit both research programs and lead to new synergies that include basic research, clinical translation, and training of the next generation of scientists and engineers.

项目摘要 该项目将在小说0.55上开发体积实时磁共振成像（RT-MRI）技术 特斯拉平台可改善对运动中心脏和气道的评估。理由：体积实现 - 计算机断层扫描和超声检查的时间成像对我们理解的能力产生了深远的影响 并评估涉及运动和移动器官的疾病。这些方式各有局限性 包括电离辐射，可视化角度阻塞和对比度有限。 MRI目前能够切片 宽带RT-MRI和体积的飞跃将改善对广泛心脏和气道的评估 疾病。创新：NIH开发了0.55 Tesla MRI仪器，我们认为这将使一项突破 在RT-MRI性能中。这是由于显着降低的呼声效应，大幅降低了组织 加热以及由于MRI脉冲序列的柔韧性提高而导致的扫描效率飞跃。我们提出了一个 创新的壁内伙伴关系和跨学科团队探索这一潜力。方法： 该项目的目的是开发和翻译提供的低延迟体积RT-MRI方法 空前的时空分辨率和空间覆盖范围，将使几个心脏和气道受益 申请。特别是：我们将：1开发和技术验证体积RT-MRI数据采集 0.55T场强，2开发和技术验证低延迟体积RT-MRI重建，人工制品 缓解和分割，以及在两个独特的患者队列中的临床评估体积RT-MRI NIH临床中心可能会立即对护理产生直接影响 - 患者是气管菌和患者 复发性多发性炎（n = 20），并接受MRI引导性心脏导管插入术的患者（n = 20）。 更广泛的影响：拟议的体积RT-MRI技术是可以推广的，并且可以使许多其他 应用，例如心律不齐中的心脏功能评估和阻塞性的上呼吸道评估 睡眠呼吸暂停。壁内和壁外实验室各自提供独特而完整的专业知识来实现​​这一目标 雄心勃勃的技术发展。创建这种新的壁内 - 外部合作将受益 研究计划并导致新的协同作用，包括基础研究，临床翻译和培训 下一代科学家和工程师。