Coherent hemodynamics spectroscopy for cerebral autoregulation and blood flow

用于脑自动调节和血流的相干血流动力学光谱

• 批准号: 9921500
• 负责人: SERGIO FANTINI
• 金额: $ 50.22万
• 依托单位: TUFTS UNIVERSITY MEDFORD
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9921500
• 关键词: Acute; Age; Aging; Aneurysmal Subarachnoid Hemorrhages; Biomedical Engineering; Blood Volume; Blood capillaries; Blood flow; Brain; Brain Mapping; Cardiopulmonary Bypass; Cerebral Ischemia; Cerebrovascular Circulation; Cerebrum; Chronic; Clinical; Clinical Management; Comparative Study; Critical Care; Data; Data Analyses; Development; Dialysis procedure; Diffuse; Discrimination; Disease; Effectiveness; Frequencies; Hemodialysis; Homeostasis; Impaired cognition; Impairment; Interdisciplinary Study; Ischemic Stroke; Licensing; Measurement; Measures; Medical; Medical center; Methods; Microcirculation; Modeling; Monitor; Near-Infrared Spectroscopy; Neurocognitive; Neurologic; Neurologist; Neurology; Optical Methods; Patients; Peer Review; Perfusion; Physiological; Procedures; Protocols documentation; Publications; Regulation; Reporting; Reproducibility; Research; Spectrum Analysis; Sphygmomanometers; Stroke; Subarachnoid Hemorrhage; Techniques; Technology; Testing; Therapeutic Intervention; Thigh structure; Time; Tissue imaging; Tissues; Translating; Traumatic Brain Injury; Venous; base; blood flow measurement; brain tissue; cerebral hemodynamics; cerebrovascular; cerebrovascular disorder diagnosis; diabetic; diabetic patient; diffuse optical spectroscopy and imaging; hemodynamics; high risk; hypoperfusion; improved; innovation; instrument; mathematical model; neurovascular; new technology; novel; patient population; pressure; public health relevance; research clinical testing; success; tool

Project Summary: This project aims to develop a novel non-invasive technique, coherent hemodynamics spectroscopy (CHS), for the local measurement of brain perfusion and autoregulation at the microvascular level. This new technique consists of three components: (1) An experimental method based on diffuse near- infrared spectroscopy (NIRS) to non-invasively collect brain perfusion data at the microcirculation level; (2) Mild perturbations in the systemic mean arterial pressure to evoke oscillations or transients in the cerebral hemodynamics; (3) The application of a new hemodynamic model to translate NIRS measurements of cerebral hemodynamics into measurements of physiological and functional quantities. Specifically, this proposal focuses on CHS measurements of dynamic cerebral autoregulation (dCA) and capillary transit time (CTT), which yields absolute cerebral blood flow (CBF). The capability of CHS to measure local CTT, CBF, and dCA will be capitalized by developing spatially-resolved CHS (for brain mapping) and depth-resolved CHS (for discrimination of extracerebral and brain tissues). We plan clinical tests at two units at the Tufts Medical Center, namely the dialysis unit and the neurological critical care unit, to demonstrate the clinical potential of CHS. The first clinical test, on diabetic hemodialysis patients, aims to validate CHS measurements of CBF and dCA in a comparative study with age-matched healthy controls, and to demonstrate the potential of CHS to detect a reduction in cerebral perfusion during hemodialysis. The second clinical test, on patients who suffered from aneurysmal Subarachnoid Hemorrhage (aSAH) and Traumatic Brain Injury (TBI), will directly test the clinical potential of CHS in monitoring cerebral perfusion and autoregulation deficits. The broad objective of this application is the development of a new tool for the quantitative, non-invasive assessment of local cerebrovascular hemodynamics at the microcirculation level. CHS offers a significant clinical potential as a result of its ability to non-invasively assess and monitor brain tissue perfusion, which is impaired in a variety of clinical conditions, including subarachnoid hemorrhage, traumatic brain injury, hemodialysis treatment, ischemic stroke, and cardiopulmonary bypass.

项目成果

Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy.

• DOI: 10.1117/1.nph.10.1.013508
• 发表时间: 2023-01
• 期刊: Neurophotonics
• 影响因子: 5.3

Method for Measuring Absolute Optical Properties of Turbid Samples in a Standard Cuvette.

标准比色皿中浑浊样品绝对光学性质的测量方法。

• DOI: 10.3390/app122110903
• 发表时间: 2022
• 期刊: Applied sciences (Basel, Switzerland)
• 作者: Blaney,Giles;Sassaroli,Angelo;Fantini,Sergio
• 通讯作者: Fantini,Sergio

Dual-slope imaging in highly scattering media with frequency-domain near-infrared spectroscopy.

• DOI: 10.1364/ol.394829
• 发表时间: 2020-08-15
• 期刊: OPTICS LETTERS
• 影响因子: 3.6
• 作者: Blaney, Giles;Sassaroli, Angelo;Fantini, Sergio
• 通讯作者: Fantini, Sergio

Dual-slope method for enhanced depth sensitivity in diffuse optical spectroscopy.

双斜率方法可增强漫光谱中的深度灵敏度。

• DOI: 10.1364/josaa.36.001743
• 发表时间: 2019
• 期刊: Journal of the Optical Society of America. A, Optics, image science, and vision
• 作者: Sassaroli,Angelo;Blaney,Giles;Fantini,Sergio
• 通讯作者: Fantini,Sergio

Design of a source-detector array for dual-slope diffuse optical imaging.

• DOI: 10.1063/5.0015512
• 发表时间: 2020-09
• 期刊: The Review of scientific instruments
• 作者: Giles Blaney;A. Sassaroli;S. Fantini