Longitudinal Investigation of Fertility and the Environment

生育力与环境的纵向调查

• 批准号: 8149320
• 负责人: Germaine Louis
• 金额: $ 9.63万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8149320
• 关键词: Cotinine; Couples; Data Analyses; Environment; Fertility; Investigation

The purpose of the LIFE Study is to assess the impact of environmental factors, broadly defined to include lifestyle factors, on human reproduction and development. The LIFE Study is consistent with the mission of the National Institute of Child Health and Human Development that includes conducting basic, clinical and epidemiologic research focusing on factors and processes associated with human reproduction and development thereby, ensuring the birth of healthy infants capable of reaching full adult potential unimpaired by physical or mental disabilities. This study will assess the relation between select environmental factors and human fecundity and fertility. This research proposes to recruit and retain 800 couples interested in becoming pregnant and willing to participate in a longitudinal study. Couples will be selected from geographic regions that were chosen from peer reviewed competitive proposals. Fecundity will be measured by the time required for the couples to achieve pregnancy, while fertility will be measured by the ability of couples to have a live born infant. Infertility will be recognized for couples unable to conceive within 12 months of trying. The studys primary environmental exposures include: organochlorine pesticides; polychlorinated biphenyls; polybrominated diphenyl ethers; metals; perfluorinated compounds; cotinine; and phytoestrogens. A growing body of literature suggests these compounds may exert adverse effects on human reproduction and development; however, definitive data are lacking especially for sensitive endpoints. Couples will participate in a 25-minute baseline interview and be instructed in the use of home fertility monitors and pregnancy kits for counting the time required for pregnancy and detecting pregnancy. Blood and urine samples will be collected at baseline from both partners of the couple for measurement of the environmental exposures. Two semen samples from male partners and two saliva samples from female partners also will be requested. Semen samples will be used to globally assess male fecundity as measured primarily by sperm concentration and morphology. Saliva samples will be used for the measurement of cortisol levels as a marker of stress among female partners so that the relation between environmental factors, stress and human reproduction can be assessed. The findings will provide valuable information regarding the effect of environmental contaminants on sensitive markers of human reproduction and development, filling critical data gaps. Moreover, these environmental exposures will be analyzed in the context of other lifestyle exposures such as use of cigarettes and alcohol, consistent with the manner in which human beings are exposed. Data analysis is just beginning.

生命研究的目的是评估环境因素的影响，广泛定义为包括生活方式因素，对人类繁殖和发展的影响。 生活研究与国家儿童健康与人类发展研究所的使命是一致的，该研究所包括进行基本，临床和流行病学研究，重点关注与人类繁殖和发展相关的因素和过程，从而确保健康婴儿的诞生，能够实现能够达到全部成人潜在的潜在潜在潜在的身体或精神上的潜在影响。 这项研究将评估某些环境因素与人类繁殖力和生育能力之间的关系。 这项研究建议招募并保留800对有兴趣怀孕并愿意参加纵向研究的夫妇。 夫妻将从从同行评审的竞争建议中选择的地理区域中选择。 繁殖力将通过夫妻实现怀孕所需的时间来衡量，而生育能力将通过夫妻有活生生婴儿的能力来衡量。 不孕症将因在尝试后的12个月内无法构想而被认可。 Studys的主要环境暴露包括：有机氯农药；多氯联苯;多溴二苯基醚；金属；全氟化化合物； cotinine;和植物雌激素。 越来越多的文献表明，这些化合物可能对人类繁殖和发育产生不利影响。但是，缺乏确定的数据，尤其是对于敏感的终点。 夫妻将参加25分钟的基线访谈，并指示使用家庭生育监测器和怀孕套件来计算怀孕和检测怀孕所需的时间。 将在这对夫妇的两个伴侣的基线上收集血液和尿液样本，以测量环境暴露。 还将要求来自男性伴侣的两个精液样本和两个女性伴侣的唾液样本。 精液样品将用于全球评估男性繁殖力，主要是通过精子浓度和形态来测量的。 唾液样本将用于测量皮质醇水平，作为女性伴侣的压力标志，以便可以评估环境因素，压力和人类繁殖之间的关系。 这些发现将提供有关环境污染物对人类繁殖和开发敏感标记的影响的有价值的信息，从而填补了关键的数据差距。 此外，将在其他生活方式暴露（例如使用香烟和酒精）的情况下分析这些环境暴露，这与人类暴露的方式一致。 数据分析才刚刚开始。