ENDO Study: Endometriosis, Natural History and Diagnosis

ENDO 研究：子宫内膜异位症、自然史和诊断

基本信息

批准号：
8351214
负责人：
Germaine Louis
金额：
$ 6.5万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8351214
关键词：
Affect Age Area Authorization documentation Blood California Chemicals Clinics and Hospitals Diagnosis Dimensions Disease Dose Employment Endometrial Ensure Environment Environmental Pollution Epidemiologic Studies Estrogens Etiology Exposure to Fatty acid glycerol esters Female Fertility Geographic Locations Goals Gynecologic Gynecologic Pathology Health Health Status Infertility Interview Laboratories Laparoscopy Laparotomy Life Life Style Measurement Measures Medical History Mental Health National Health Interview Survey Natural History Operative Surgical Procedures Pelvic Pain Peritoneal Fluid Physical activity Prevalence Publications Reproduction Reproductive Health Research Risk Role Sampling Serum Sex Functioning Surgeon Tissues Urine Utah Uterus Woman aged cohort design endometriosis environmental chemical lifestyle factors organochlorine pesticide reproductive

项目摘要

The ENDO Study is a collaborative epidemiologic study whose goal is to assess the relation between exposure to environmental chemicals and lifestyle factors that may affect womens reproductive health. Particular focus will be on the relation between hormonally active chemicals and risk of developing endometriosis considering womens lifestyles. Endometriosis is a condition in which endometrial tissue is found outside the uterus and can be associated with pelvic pain, menstrual changes and infertility. Approximately 10% of women aged 18-44 years may be affected, and many cases may be currently undetected. To date, the cause of endometriosis is unknown and, increasingly, an environmental etiology is suspected for some affected women. To answer questions about the effect of the environment and lifestyle on womens gynecologic health, the ENDO Study will use an operative cohort design. Women aged 18-44 years residing in geographically defined areas of California and Utah who are undergoing laparoscopy or laparotomy are eligible for inclusion in this study, along with women who reside in geographic areas served by participating hospitals and clinics. Participation in the study asks women to: 1) complete an interview to provide information about lifestyle and medical history; 2) complete an anthropometric assessment to measure fatness and 3) provide blood and urine samples for the measurement of chemicals. Women undergoing surgery will be asked permission for the surgeon to remove fat, peritoneal fluid and endometrial tissue for laboratory analysis to help identify the cause(s) of endometriosis. Publications are underway.

ENDO研究是一项合作的流行病学研究，其目标是评估可能影响女性生殖健康的环境化学物质和生活方式因素之间的关系。特别关注荷尔蒙活性化学物质与考虑女性生活方式的子宫内膜异位症的风险之间的关系。子宫内膜异位症是在子宫外发现子宫内膜组织的疾病，并且可能与骨盆疼痛，月经变化和不育有关。大约10％的18-44岁妇女可能受到影响，目前可能未发现许多病例。迄今为止，子宫内膜异位症的原因尚不清楚，并且越来越多地怀疑某些受影响的妇女的环境病因。为了回答有关环境和生活方式对女性妇科健康的影响的问题，Endo研究将使用手术队列设计。居住在加利福尼亚和犹他州的地理定义区域的18-44岁妇女正在接受腹腔镜检查或剖腹手术，并有资格纳入这项研究，以及居住在参与医院和诊所服务的地理区域的妇女。参与研究要求妇女：1）完成一次面试，以提供有关生活方式和病史的信息； 2）完成人体测量评估以测量脂肪，3）为化学物质的测量提供血液和尿液样本。接受手术的妇女将被要求允许外科医生去除脂肪，腹膜液和子宫内膜组织进行实验室分析，以帮助确定子宫内膜异位症的原因。出版物正在进行中。