Impact of Psychosocial Stress on Time-to-Pregnancy

心理社会压力对怀孕时间的影响

• 批准号: 8351184
• 负责人: Germaine Louis
• 金额: $ 7万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8351184
• 关键词: Anxiety; Biological Markers; Clinical Trials Design; Conceptions; Control Locus; Data; Data Analyses; Enrollment; Feedback; Female; Fertility; Follow-Up Studies; Hydrocortisone; Measures; Mental Depression; Monitor; Moods; National Institute of Child Health and Human Development; Physiological; Pregnancy; Pregnancy Rate; Psychosocial Stress; Questionnaires; Randomized Clinical Trials; Research; Research Personnel; Role; Saliva; Salivary; Sampling; Social support; Stress; Time; Universities; Woman; alpha-amylase; arm; base; diaries; digital; instrument; pregnant; psychosocial; self esteem

NICHD is collaborating with Dr. Cecilia Pyper, Oxford University, to assess the impact of psychosocial stress on female fecundity as measured by time-to-pregnancy. Specifically, NICHD will build a stress component into Dr. Pypers currently ongoing Oxford Conception Study (OCS). The OCS is a three-arm randomized clinical trial designed to evaluate whether or not daily feedback from a digital fertility monitor increases the conception rate among women desiring pregnancy. Women enrolled in the OCS are followed for up to six months as they try to conceive. During this time, women send daily diary information, a mood questionnaire and data from their fertility monitor to the investigators on a monthly basis. Three-month and six-month cumulative pregnancy rates will be compared for the women in each of the three groups. NICHD has added a component to the Oxford Conception Study (OCS) with the expressed intent of measuring stress and its impact on female fecundity among newly enrolled women in the OCS (approximately 400 women). The NICHDs research objectives are: 1) to evaluate the effect of perceived psychosocial stress on time to pregnancy; 2) to evaluate the effect of physiologic stress on time to pregnancy; 3) to assess whether or not perceived psychosocial stress is associated with physiologic stress; and 4) to assess whether or not underlying anxiety and depression, social support, locus of control, or self-esteem confound or modify the relation between perceived psychosocial stress or physiologic stress and time-to-pregnancy. Saliva samples will be analyzed for two biomarkers of stress, viz., cortisol and alpha amylase. The Cohens Perceived Stress Scale will be used to measure perceived psychosocial stress. Several other psychosocial instruments will be administered at baseline to allow us to assess whether or not they confound or modify the relation between physiologic stress or perceived psychosocial stress and time-to-pregnancy. Data analysis has been completed for salivary biomarkers and TTP. Additional data analysis of psychosocial stress and TTP is underway.

NICHD正在与牛津大学的Cecilia Pyper博士合作，以评估心理压力对女性繁殖力的影响，如怀孕时间的衡量。 具体而言，NICHD将为当前正在进行的牛津构想研究（OCS）的Pypers博士建立压力成分。 OCS是一项三臂随机临床试验，旨在评估数字生育率监测仪的每日反馈是否会增加渴望怀孕的女性的受孕率。 在OCS中入学的妇女在试图怀孕时最多六个月。 在此期间，妇女每月向调查人员发送每日日记信息，情绪调查表以及其生育监测仪的数据。 将比较三组女性的三个月和六个月累积妊娠率。 NICHD已在牛津构想研究（OCS）中增加了一个组成部分，其意图是测量应力及其对OCS新入学的女性（约400名女性）中女性繁殖力的影响。 NICHDS的研究目标是：1）评估感知到的社会心理压力对怀孕时间的影响； 2）评估生理压力对时间的影响； 3）评估感知的心理压力是否与生理压力有关； 4）评估是否潜在的焦虑和抑郁，社会支持，控制源或自尊心混淆或修改感知的社会心理压力或生理压力与怀孕时间之间的关系。 唾液样品将分析两个胁迫的生物标志物，即皮质醇和α淀粉酶。 Cohens感知的压力量表将用于衡量感知到的社会心理压力。 将在基线时管理其他几种社会心理仪器，以使我们能够评估它们是否混淆或修改生理压力或感知的社会心理压力和怀孕时间之间的关系。 唾液生物标志物和TTP的数据分析已完成。 心理压力和TTP的其他数据分析正在进行中。