ENDO Study: Endometriosis, Natural History and Diagnosis

ENDO 研究：子宫内膜异位症、自然史和诊断

• 批准号: 8941516
• 负责人: Germaine Louis
• 金额: $ 5.6万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8941516
• 关键词: Affect; Age; Area; Blood; Catchment Area; Chemical Exposure; Chemicals; Cities; Clinic; Clinical; Diagnosis; Disease; Endometrial; Environmental Pollution; Epidemiologic Studies; Estrogens; Etiology; Exposure to; Fatty acid glycerol esters; Fibroid Tumor; Goals; Gynecologic; Gynecologic Pathology; Health; Implant; Infertility; Interview; Life; Magnetic Resonance Imaging; Natural History; Omentum; Operative Surgical Procedures; Pelvic Pain; Pelvis; Peritoneal Fluid; Population; Proteome; Recruitment Activity; Reproductive Health; Research; Role; Sampling; San Francisco; Serum; Sodium Chloride; Tissues; Urine; Uterus; Woman; aged; cohort; design; endometriosis; environmental chemical; lifestyle factors; reproductive; residence

The ENDO Study is a collaborative epidemiologic study whose goal is to assess the relation between exposure to environmental chemicals and lifestyle factors that may affect womens reproductive health. Both persistent and non-persistent chemicals are being assessed in relation to the odds of an incident diagnosis of endometriosis. Endometriosis is a condition in which endometrial tissue is found outside the uterus and can be associated with pelvic pain, menstrual changes and infertility. Approximately 11% of women aged 18-44 years may be affected, and many cases may be currently undetected. To date, the cause of endometriosis is unknown and, increasingly, an environmental etiology is suspected for some affected women. A matched cohort design was utilized to establish two cohorts of women - operative and population. 495 women were recruited from 14 participating clinics located in the San Francisco and Salt Lake City areas. This operative cohort was matched on age and residence with a 50-mile catchment area of participating clinical centers to establish a population cohort comprising 131 women who underwent pelvic MRIs to identify endometriosis or its absence. Women participated in baseline interviews and provided blood and urine samples priort to surgery or MRI. Additional operative biospecimens were obtained from the operative cohort when available (i.e., omentum fat, peritoneal fluid, endometrial implants). Serum, fat and urine samples have undergone toxicologic analysis for the quantification of persistent and short lived chemical exposures to assess their relation with endometriosis and, eventually, other gynecologic conditions such as fibroids.

ENDO研究是一项合作的流行病学研究，其目标是评估可能影响女性生殖健康的环境化学物质和生活方式因素之间的关系。 正在评估持久性和非持久化学物质因子宫内膜异位症的事件诊断的几率而评估。 子宫内膜异位症是在子宫外发现子宫内膜组织的疾病，并且可能与骨盆疼痛，月经变化和不育有关。 大约11％的18-44岁妇女可能受到影响，目前可能未发现许多病例。 迄今为止，子宫内膜异位症的原因尚不清楚，并且越来越多地怀疑某些受影响的妇女的环境病因。 匹配的队列设计被用来建立两名妇女 - 手术和人口。 从旧金山和盐湖城地区的14个参与诊所招募了495名妇女。 该手术队列的年龄和居住与参与临床中心的50英里集水区相匹配，以建立一个人群队列，其中包括131名经过骨盆MRI的妇女，以鉴定子宫内膜异位症或缺席。 妇女参加了基线访谈，并为手术或MRI提供了血液和尿液样本。 如果可用的（即，大膜脂肪，腹膜液，子宫内膜植入物），从手术队列中获得了其他手术生物测量。 血清，脂肪和尿液样品已经进行了毒理学分析，以定量持久性和短寿命的化学暴露，以评估其与子宫内膜异位症的关系，并最终在其他妇科条件（如辅助辅助状态）（例如肌瘤）。