Rate of Weight Gain, Linear Growth, and Development During Childhood

儿童时期的体重增加率、线性生长和发育

• 批准号: 8046780
• 负责人: Joyce Lee
• 金额: $ 8.4万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-27 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8046780
• 关键词: 15 year old; Adolescence; Adolescent; Adult; Age; Automobile Driving; Birth; Body mass index; Breast; Centers for Disease Control and Prevention (U.S.); Child; Child Care; Child health care; Childhood; Chronic Disease; Clinic; Clinical; Data; Development; Ensure; Epidemic; Etiology; Gender; Genital system; Growth; Growth and Development function; Health; Height; Human; Human Development; Individual; Institutes; Link; Measurement; Obesity; Overweight; Pattern; Population; Provider; Puberty; Reporting; Research; Sampling; Socioeconomic Status; Staging; Time; Weight; Weight Gain; base; boys; clinical practice; cohort; disorder risk; early childhood; early onset; girls; improved; insight; obesity in children; population based; pubertal timing; socioeconomics

DESCRIPTION (provided by applicant): Increases in weight gain among US children related to the childhood obesity epidemic may result in alteration of normal patterns of childhood linear growth and development. Few studies have evaluated the impact of weight gain on linear growth patterns or the relationship of linear growth with pubertal timing for a population- based sample of US children followed longitudinally. Using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development, a comprehensive study which collected longitudinal growth and puberty measurements on a population-based cohort of children of diverse socioeconomic status from birth to age 15 years, this proposal provides an unprecedented opportunity to evaluate the following specific aims: Aim 1: To evaluate the association of early childhood (ages 2 -7 years) BMI increases with height gain during early childhood (ages 2-7 years) and how this association varies by gender. Aim 2: To evaluate the association of early childhood (ages 2 -7 years) BMI increases with the timing and magnitude of the adolescent growth spurt (peak height velocity) and height gain during adolescence (ages 9 - 15 years) separately for boys and girls. Aim 3: To evaluate the relationship between timing of height takeoff and peak height velocity with puberty separately for boys and girls. Aim 4: To assess the % of children in the population classified as early, average, and late maturers, based on their individual height velocity curves, and to compare BMI z-scores, increases in BMI during early childhood, and proportion overweight and obese, between early, average, and late maturers for boys and for girls. Results of the proposed study will offer an improved understanding of the relationship between weight gain in early childhood and alterations in patterns of linear growth, as well as the relationship between linear growth patterns and pubertal timing. This information is critical for ensuring accurate interpretation of childhood growth patterns in clinical practice, as well as for offering important insights into mechanisms of childhood linear growth and development. PUBLIC HEALTH RELEVANCE: The epidemic of childhood obesity among US children may result in alterations of normal patterns of childhood linear growth and development. Studies to evaluate the impact of weight gain and obesity on childhood linear growth and development will have practical implications regarding interpretation of the etiology of children's growth patterns, as well as theoretic implications regarding the potential mechanism of excess adiposity in driving growth and development.

描述（由申请人提供）：与儿童肥胖流行相关的美国儿童体重增加可能会导致儿童线性生长和发育的正常模式改变。很少有研究评估体重增加对线性生长模式的影响，或者对基于人口的美国儿童样本的线性生长与青春期时间的关系进行纵向跟踪。使用国家儿童健康和人类发展研究所的早期儿童保育和青少年发展研究的数据，这是一项综合研究，收集了基于人群的不同社会经济地位的儿童从出生到 15 岁的纵向生长和青春期测量数据，该提案为评估以下具体目标提供了前所未有的机会： 目标 1：评估幼儿期（2 -7 岁）BMI 随幼儿期（2-7 岁）身高增加之间的关系以及这种关联如何变化按性别。目标 2：分别评估儿童早期（2 -7 岁）BMI 增加与青少年生长突增（身高峰值速度）的时间和幅度以及青春期（9 - 15 岁）身高增长之间的关系，分别针对男孩和儿童女孩们。目标 3：分别评估男孩和女孩的身高起飞时间和身高峰值速度与青春期之间的关系。目标 4：根据个体身高速度曲线评估儿童在人口中被划分为早熟、平均和晚熟儿童的百分比，并比较 BMI z 分数、幼儿期 BMI 的增加以及超重和肥胖的比例，介于男孩和女孩的早熟、平均和晚熟之间。拟议研究的结果将有助于更好地理解儿童早期体重增加与线性生长模式改变之间的关系，以及线性生长模式与青春期时间之间的关系。这些信息对于确保在临床实践中准确解释儿童生长模式以及为儿童线性生长和发育机制提供重要见解至关重要。 公共卫生相关性：美国儿童中儿童肥胖的流行可能会导致儿童线性生长和发育的正常模式发生改变。评估体重增加和肥胖对儿童线性生长和发育的影响的研究将对解释儿童生长模式的病因学产生实际影响，并对过度肥胖驱动生长和发育的潜在机制产生理论影响。