Rate of Weight Gain, Linear Growth, and Development During Childhood

儿童时期的体重增加率、线性生长和发育

基本信息

批准号：
8209032
负责人：
Joyce Lee
金额：
$ 8.38万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-12-27 至 2012-11-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Increases in weight gain among US children related to the childhood obesity epidemic may result in alteration of normal patterns of childhood linear growth and development. Few studies have evaluated the impact of weight gain on linear growth patterns or the relationship of linear growth with pubertal timing for a population- based sample of US children followed longitudinally. Using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development, a comprehensive study which collected longitudinal growth and puberty measurements on a population-based cohort of children of diverse socioeconomic status from birth to age 15 years, this proposal provides an unprecedented opportunity to evaluate the following specific aims: Aim 1: To evaluate the association of early childhood (ages 2 -7 years) BMI increases with height gain during early childhood (ages 2-7 years) and how this association varies by gender. Aim 2: To evaluate the association of early childhood (ages 2 -7 years) BMI increases with the timing and magnitude of the adolescent growth spurt (peak height velocity) and height gain during adolescence (ages 9 - 15 years) separately for boys and girls. Aim 3: To evaluate the relationship between timing of height takeoff and peak height velocity with puberty separately for boys and girls. Aim 4: To assess the % of children in the population classified as early, average, and late maturers, based on their individual height velocity curves, and to compare BMI z-scores, increases in BMI during early childhood, and proportion overweight and obese, between early, average, and late maturers for boys and for girls. Results of the proposed study will offer an improved understanding of the relationship between weight gain in early childhood and alterations in patterns of linear growth, as well as the relationship between linear growth patterns and pubertal timing. This information is critical for ensuring accurate interpretation of childhood growth patterns in clinical practice, as well as for offering important insights into mechanisms of childhood linear growth and development. PUBLIC HEALTH RELEVANCE: The epidemic of childhood obesity among US children may result in alterations of normal patterns of childhood linear growth and development. Studies to evaluate the impact of weight gain and obesity on childhood linear growth and development will have practical implications regarding interpretation of the etiology of children's growth patterns, as well as theoretic implications regarding the potential mechanism of excess adiposity in driving growth and development.

描述（由申请人提供）：与儿童肥胖相关的儿童体重增加增加可能会导致儿童线性生长和发育的正常模式改变。很少有研究评估了体重增加对线性生长模式的影响或线性生长与青春期时间的关系对我们的基于人群的孩子样本的关系纵向遵循。 Using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development, a comprehensive study which collected longitudinal growth and puberty measurements on a population-based cohort of children of diverse socioeconomic status from birth to age 15 years, this proposal provides an unprecedented opportunity to evaluate the following specific aims: Aim 1: To evaluate the association of early childhood (ages 2 -7 years) BMI increases with height gain during early童年（2-7岁）以及这种关联如何随性别而变化。目标2：评估儿童早期（2 -7岁）的关联，BMI随着青春期增长的时间和幅度的增加而增加（峰值高度速度）和青春期（9-15岁年龄段）的男孩和女孩的高度增长。 AIM 3：评估男孩和女孩的高度起飞时机与青春期的高度速度与峰值高速速度之间的关系。 AIM 4：根据他们的个人身高速度曲线评估人群中归类为早期，平均和晚期成熟的儿童的百分比，并比较BMI Z分数，在童年时期，BMI的增长以及男孩和女孩的早期，平均和肥胖的比例超重，男孩和女孩的早期和肥胖。拟议研究的结果将对幼儿体重增加与线性生长模式的变化以及线性生长模式与青春期时机之间的关系有了改进的了解。该信息对于确保在临床实践中准确解释儿童生长模式以及对儿童线性生长和发育机制的重要见解至关重要。公共卫生相关性：我们儿童儿童肥胖的流行可能会导致儿童期线性生长和发展的正常模式改变。评估体重增加和肥胖对儿童线性生长和发育的影响的研究将对解释儿童生长模式的病因的解释以及关于过量肥胖在推动生长和发展中的潜在机制的理论意义。