Childhood Obesity and Type 2 Diabetes Trends: A Life Course Analysis

儿童肥胖和 2 型糖尿病趋势：生命历程分析

• 批准号: 7440720
• 负责人: Joyce Lee
• 金额: $ 14.72万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7440720
• 关键词: Accounting; Address; Affect; Age; Age of Onset; Cardiovascular system; Cations; Child; Child health care; Childhood; Chronic Disease; Cohort Analysis; Complications of Diabetes Mellitus; Coupled; Development; Diabetes Mellitus; Employee Strikes; Endocrinologist; Epidemic; Epidemiologic Studies; Epidemiology; Evaluation Research; Event; Future; Health Policy; Health Services; Healthcare; Incidence; Lead; Life; Life Cycle Stages; Life Expectancy; Link; Mentors; Mentorship; Michigan; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Policies; Population; Prevalence; Prevention; Public Health Schools; Publishing; Rate; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Staging; Time; Training; Universities; base; cohort; diabetes risk; disorder risk; early onset; experience; health care delivery; illness length; multidisciplinary; novel; programs; skills; trend; young adult

DESCRIPTION (provided by applicant): This proposal will provide Dr. Joyce Lee with the analytic skills and research experience for becoming an independent researcher focused on obesity and type 2 diabetes over the life course. Dr. Lee will build on her unique training as a pediatric endocrinologist and pediatric health services researcher with a program of advanced coursework focused on quantitative skills in epidemiology, applied modeling, and child health policy. Her accomplished mentoring team includes Dr. William Herman, MD, MPH, and Dr. Gary Freed MD, MPH, and resources such as the Michigan Diabetes Research and Training Center, the Child Health Evaluation and Research Unit, and the School of Public Health at the University of Michigan. With this project, Dr. Lee proposes a novel life course approach for understanding the long-term consequences of childhood obesity with regard to type 2 diabetes risk. Rates of childhood obesity are accelerating over time, with large increases in prevalence and magnitude of obesity, as well as earlier onset of obesity. Despite this trend, population-based studies suggest that rates of T2D among children have not yet increased substantially, which may reflect the latency period between the onset of obesity and the development of T2D, which can last upwards of 10 years of more. Therefore, the epidemic of childhood obesity may result in large increases in T2D among young adults, which is of great concern due to higher rates of cardiovascular and end-stage complications from a longer duration of disease. In this proposal, Dr. Lee will evaluate the epidemiologic link between childhood obesity and T2D among young adults using age-period-cohort analyses, and will examine how both degree of excess BMI and duration of obesity early in life affect the rate and age at onset of T2D. She will then develop a state transition model to project future trends in T2D which account for recent increases in childhood obesity. Finally she will identify the policy implications of her findings from the epidemiologic studies and the state transition model to identify and prioritize changes in child health policy and health care delivery needed for addressing childhood obesity as a chronic disease risk factor originating in childhood and extending into adulthood.

描述（由申请人提供）：该提案将为乔伊斯·李博士提供分析技能和研究经验，以成为专注于肥胖和2型糖尿病的独立研究人员。 Lee博士将以她作为儿科内分泌学家和儿科健康服务研究人员的独特培训为基础，其高级课程计划着重于流行病学，应用建模和儿童健康政策的定量技能。她成熟的指导团队包括MD，MPH医学博士William Herman博士和MPH的Gary Freed MD博士以及密歇根州糖尿病研究与培训中心，儿童健康评估与研究部门以及密歇根大学公共卫生学院。通过这个项目，李博士提出了一种新颖的生活课程方法，以了解2型糖尿病风险对儿童肥胖的长期后果。随着时间的流逝，儿童肥胖的率正在加速，肥胖症的患病率和次数很大，肥胖症的早期发作。尽管有这种趋势，但基于人群的研究表明，儿童的T2D率尚未大大增加，这可能反映了肥胖发作与T2D发展之间的潜伏期，这可以持续10年以上。因此，儿童肥胖症的流行可能导致年轻人的T2D大幅增加，这是由于较长的疾病持续时间的心血管和终阶段并发症的率较高，因此引起了极大的关注。在这项建议中，Lee博士将使用年龄 - 周期 - 霍特分析的年轻人中儿童肥胖与T2D之间的流行病学联系，并将研究过多的BMI和生命早期肥胖时间的程度如何影响T2D的发病率和年龄。然后，她将开发一个国家过渡模型，以预测T2D的未来趋势，这解释了儿童肥胖症的最新增加。最后，她将从流行病学研究和国家过渡模型中确定她的发现的政策影响，以确定和优先考虑儿童健康政策和医疗保健服务的变化，以解决儿童肥胖症作为一种慢性疾病危险因素，起源于儿童时期并延伸到成年。