Childhood Obesity and Type 2 Diabetes Trends: A Life Course Analysis

儿童肥胖和 2 型糖尿病趋势：生命历程分析

• 批准号: 7440720
• 负责人: Joyce Lee
• 金额: $ 14.72万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7440720
• 关键词: Accounting; Address; Affect; Age; Age of Onset; Cardiovascular system; Cations; Child; Child health care; Childhood; Chronic Disease; Cohort Analysis; Complications of Diabetes Mellitus; Coupled; Development; Diabetes Mellitus; Employee Strikes; Endocrinologist; Epidemic; Epidemiologic Studies; Epidemiology; Evaluation Research; Event; Future; Health Policy; Health Services; Healthcare; Incidence; Lead; Life; Life Cycle Stages; Life Expectancy; Link; Mentors; Mentorship; Michigan; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Policies; Population; Prevalence; Prevention; Public Health Schools; Publishing; Rate; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Staging; Time; Training; Universities; base; cohort; diabetes risk; disorder risk; early onset; experience; health care delivery; illness length; multidisciplinary; novel; programs; skills; trend; young adult

DESCRIPTION (provided by applicant): This proposal will provide Dr. Joyce Lee with the analytic skills and research experience for becoming an independent researcher focused on obesity and type 2 diabetes over the life course. Dr. Lee will build on her unique training as a pediatric endocrinologist and pediatric health services researcher with a program of advanced coursework focused on quantitative skills in epidemiology, applied modeling, and child health policy. Her accomplished mentoring team includes Dr. William Herman, MD, MPH, and Dr. Gary Freed MD, MPH, and resources such as the Michigan Diabetes Research and Training Center, the Child Health Evaluation and Research Unit, and the School of Public Health at the University of Michigan. With this project, Dr. Lee proposes a novel life course approach for understanding the long-term consequences of childhood obesity with regard to type 2 diabetes risk. Rates of childhood obesity are accelerating over time, with large increases in prevalence and magnitude of obesity, as well as earlier onset of obesity. Despite this trend, population-based studies suggest that rates of T2D among children have not yet increased substantially, which may reflect the latency period between the onset of obesity and the development of T2D, which can last upwards of 10 years of more. Therefore, the epidemic of childhood obesity may result in large increases in T2D among young adults, which is of great concern due to higher rates of cardiovascular and end-stage complications from a longer duration of disease. In this proposal, Dr. Lee will evaluate the epidemiologic link between childhood obesity and T2D among young adults using age-period-cohort analyses, and will examine how both degree of excess BMI and duration of obesity early in life affect the rate and age at onset of T2D. She will then develop a state transition model to project future trends in T2D which account for recent increases in childhood obesity. Finally she will identify the policy implications of her findings from the epidemiologic studies and the state transition model to identify and prioritize changes in child health policy and health care delivery needed for addressing childhood obesity as a chronic disease risk factor originating in childhood and extending into adulthood.

描述（由申请人提供）：该提案将为 Joyce Lee 博士提供分析技能和研究经验，帮助他成为一名专注于整个生命过程中肥胖和 2 型糖尿病的独立研究人员。李博士将在她作为儿科内分泌学家和儿科健康服务研究员的独特培训的基础上，开设一个高级课程项目，重点关注流行病学、应用建模和儿童健康政策的定量技能。她卓有成效的指导团队包括医学博士、公共卫生硕士 William Herman 博士和医学博士、公共卫生硕士 Gary Freed 博士，以及密歇根糖尿病研究和培训中心、儿童健康评估和研究单位以及公共卫生学院等资源。密歇根大学。通过这个项目，Lee 博士提出了一种新颖的生命全程方法，用于了解儿童肥胖对 2 型糖尿病风险的长期影响。随着时间的推移，儿童肥胖率不断加快，肥胖的患病率和严重程度大幅增加，并且肥胖发生的时间也提前。尽管存在这种趋势，基于人群的研究表明，儿童中的 T2D 发病率尚未大幅增加，这可能反映了肥胖发作和 T2D 发展之间的潜伏期，该潜伏期可能持续 10 年甚至更长。因此，儿童肥胖的流行可能会导致年轻人中T2D的大幅增加，由于病程较长导致心血管和终末期并发症的发生率较高，这一问题值得高度关注。在这项提案中，Lee 博士将使用年龄阶段队列分析来评估儿童肥胖与年轻人中 T2D 之间的流行病学联系，并将研究 BMI 过高程度和生命早期肥胖持续时间如何影响发病率和年龄。 T2D 发作。然后，她将开发一个状态转换模型来预测 T2D 的未来趋势，这解释了近期儿童肥胖的增加。最后，她将确定流行病学研究和国家转型模型的研究结果的政策含义，以确定儿童健康政策和医疗保健服务的变化并确定其优先顺序，以解决儿童肥胖作为起源于儿童期并延续到成年期的慢性疾病风险因素的问题。 。