Conventional and Metabolomic Predictors of Pediatric Prediabetes & Insulin Resist

儿童糖尿病前期的常规和代谢组学预测因子

• 批准号: 8843502
• 负责人: Joyce Lee
• 金额: $ 56.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8843502
• 关键词: Adolescence; Adolescent; Adult; American; Biological Markers; Biometry; Carbohydrates; Cardiovascular Diseases; Child; Childhood; Clinical; Cross-Sectional Studies; Development; Diabetes Mellitus; Diabetes prevention; Diagnosis; Diet; Dietary Intervention; Early Intervention; Early identification; Epidemic; Epidemiologic Studies; Epidemiology; Etiology; Functional disorder; Future; Glycosylated hemoglobin A; Growth; Health; Human; Impaired fasting glycaemia; Incidence; Individual; Insulin; Insulin Resistance; Intake; Interdisciplinary Study; Intervention; Lead; Link; Longitudinal Studies; Macronutrients Nutrition; Measures; Medical Research; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Pathogenesis; Pattern; Performance; Policies; Population; Prediabetes syndrome; Prevalence; Preventive Intervention; Puberty; Research Personnel; Research Project Grants; Risk; Risk Factors; Science; Time; Youth; cohort; diabetes risk; disorder risk; feeding; glucose tolerance; high risk; human disease; impaired glucose tolerance; insight; insulin sensitivity; interest; metabolomics; novel; nutrition; obesity in children; performance tests; polyunsaturated fat; primary care setting; response; screening; trend

DESCRIPTION (provided by applicant): Rates of prediabetes and diabetes are increasing in the pediatric population, due to the epidemic of childhood obesity. Epidemiologic studies have linked prediabetes in childhood with a higher risk of type 2 diabetes in adulthood. Because children with prediabetes represent a high-risk group of individuals who may benefit from early identification and intervention, there is increasing interest in the use of biomarkers previously validated in adults for pediatric populations. The proposed study will evaluate the longitudinal test performance of an array of conventional biomarkers of glycemia, including Hemoglobin A1c (HbA1c), and novel metabolomic biomarkers for identifying progression of glucose tolerance (normal to prediabetes or prediabetes to diabetes) in an overweight and obese pediatric cohort. In addition, a feeding study will also be conducted to examine variability in metabolomic biomarkers associated with abnormal glucose tolerance in response to macronutrient diet composition. The specific aims of this study are the following: Specific Aim #1: Assess whether conventional biomarkers of glycemia longitudinally predict progression of glucose tolerance (normal to prediabetes or prediabetes to diabetes) in a cohort of overweight/obese children. Specific Aim #2a: Identify novel metabolomic measures that longitudinally predict progression of glucose tolerance (normal to prediabetes or prediabetes to diabetes) and insulin resistance in a cohort of overweight/obese children. Specific Aim #2b: Evaluate the variability in metabolomic biomarkers associated with abnormal glucose tolerance in response to high carbohydrate and high polyunsaturated fat diets in an overweight/obese adolescent population. Application of the science of metabolomics to human disease risk is a major focus of the NIH's Roadmap for Medical Research. Although an increasing number of metabolomic studies have been conducted in adults, few studies have been conducted in children. This will be one of the first longitudinal studies to evaluate the predictive capacity of a comprehensive set of conventional and novel biomarkers for identifying adolescents with insulin sensitivity and progression of glucose tolerance status. The proposed research project represents a unique multidisciplinary collaboration of investigators with expertise in pediatric obesity and diabetes, diabetes epidemiology, metabolomics, human nutrition, and biostatistics, and will provide important information relevant for future pediatric screening policy, insights into the pathogenesis of prediabetes/type 2 diabetes during adolescence, and information on specific dietary interventions and their impact on the metabolomic 'at risk' profile.

描述（由申请人提供）：由于儿童肥胖症的流行，小儿人群的前糖尿病和糖尿病率正在增加。流行病学研究将童年时期糖尿病前期与成年期2型糖尿病风险相关。由于糖尿病前期的儿童代表了一群可能从早期识别和干预中受益的高风险人群，因此对以前在成年人中对小儿种群验证的生物标志物的使用越来越兴趣。拟议的研究将评估一系列传统的糖血症生物标志物的纵向测试性能，包括血红蛋白A1C（HBA1C）和新型的代谢生物标志物，以鉴定葡萄糖耐量的进展，以识别山水预期的葡萄糖耐受性（正常或对糖尿病的预生物学）。此外，还将进行一项喂养研究，以检查与大量营养素饮食组成相关的异常葡萄糖耐受性相关的代谢组生物标志物的变异性。这项研究的具体目的是：具体目的＃1：评估纵向纵向糖糖的常规生物标志物是否可以预测葡萄糖耐受性的进展（糖尿病前期或糖尿病前期糖尿病前期糖尿病至糖尿病）是否在超重/肥胖儿童中。具体目的＃2a：确定新型代谢组学测量方法，以纵向预测葡萄糖耐量的进展（糖尿病前期或糖尿病前期或糖尿病前期）和胰岛素抵抗在超重/肥胖儿童中。特定目标＃2b：评估与高碳水化合物和高度不饱和脂肪饮食相关的代谢组生物标志物的变异性，在超重/肥胖的青少年种群中。代谢组学科学在人类疾病风险中的应用是NIH的医学研究路线图的主要重点。尽管在成年人中已经进行了越来越多的代谢组学研究，但在儿童中很少进行研究。这将是评估一组综合的常规生物标志物和新型生物标志物的预测能力的纵向研究之一，用于识别具有胰岛素敏感性和葡萄糖耐受状态进展的青少年。拟议的研究项目代表了研究人员在儿科肥胖和糖尿病，糖尿病学，流行病学，代谢组学，人类营养和生物统计学方面具有专业知识的独特多学科合作，并将为未来的儿科筛查政策，对疾病的发病机构的发病机构提供重要的信息，并为未来的儿童筛查政策提供重要的信息，并提供有关疾病的疾病，以及对疾病的发病机构的疾病，疾病及其对疾病的发病机构及其对疾病的发病机构的影响，并提供疾病的疾病。代谢组的“处于风险”概况。