Climate Change Effects on Pregnancy via a Traditional Food

气候变化通过传统食物对怀孕的影响

• 批准号: 10822202
• 负责人: Contessa Ricci
• 金额: $ 7.65万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-02 至 2027-01-01
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10822202
• 关键词: Accounting; Acute; Address; Adult; Affect; Behavioral; Chinook Salmon; Climate; Collaborations; Communities; Complex; Conceptions; Consumption; Core Facility; Custom; Data; Development; Diet; Dietary History; Educational workshop; Environment; Environmental Risk Factor; Exposure to; Fatty Acids; Food; Gestational Diabetes; Goals; Habits; Health; Hour; Human; Indigenous; Individual; Influentials; Isotopes; Knowledge; Laboratories; Link; Literature; Longevity; Machine Learning; Maternal Health; Mercury; Methods; Modeling; Mothers; Museums; Neighborhood Health Center; Nutritional; Outcome; Pacific Northwest; Participant; Persons; Play; Population; Pregnancy; Pregnancy Outcome; Prenatal Nutrition; Prenatal care; Prospective Studies; Questionnaires; Recurrence; Research; Research Training; Risk; Risk Factors; Role; Salmon; Scientist; Security; Series; Source; Specimen; Stratification; Surveys; System; Techniques; Technology; Temperature; Testing; Time; Training; Training Programs; Tribes; Underserved Population; Universities; Validation; Vulnerable Populations; Washington; Work; adverse pregnancy outcome; career networking; climate change; climate impact; cohort; experimental study; food consumption; food insecurity; food quality; food security; health disparity; improved; innovation; interdisciplinary approach; meetings; migration; modifiable risk; mother nutrition; nutrition; offspring; pregnant; resilience; skills; social health determinants; trait

PROJECT SUMMARY Impacts of climate change on traditional food systems is of great concern for Indigenous health and currently has unknown consequences for pregnancy. Maternal diet and nutrition are highly influential in pregnancy outcome and can affect the short- and long-term health of both mothers and offspring. Yet, while changing climate regimes have documented influences on food availability and quality, there is substantial underappreciation for the environments from which foods consumed during pregnancy are sourced. Certain adverse pregnancy outcomes (APOs) have been linked to maternal diet and nutrition, and Indigenous and First Nations groups have overall higher rates of APOs. Though maternal diet and nutrition have been identified as a potential target for improving health disparities, there is a paucity of literature concerning nutrition during pregnancy in Indigenous First Nations mothers. The research proposed will help fill this critical knowledge gap by identifying how climate-driven changes in the environment can influence the nutritional quality of a traditional food source, and how this may determine Indigenous maternal health outcomes. We approach investigating this in two Specific Aims using wild Pacific salmon consumption in pregnant First Nations peoples situated within the Pacific Northwest, USA because Pacific salmon are highly sensitive to environmental factors, and many Indigenous First Nations peoples within this region have been consuming Pacific salmon as a vital traditional food from time immemorial. In Specific Aim 1, we will establish effects of climate change on Pacific salmon nutritional content by: 1) investigating historical changes in nutritional metrics of museum specimen in relation to historical temperatures; and 2) experimental validation of nutritional changes through exposure of Pacific salmon to elevated temperatures. In Specific Aim 2, we will determine if Pacific salmon nutritional content contributes to pregnancy outcome by surveying Pacific salmon consumption in pregnant First Nations individuals, and using super learners (machine learning technology) to: 1) develop a model describing the relationship between Pacific salmon-specific nutritional contributions to maternal diet and pregnancy outcome; and 2) apply the model developed to manipulated data to test if changes in Pacific salmon-specific nutritional contributions to diet can influence pregnancy outcome. The research will be carried out with community health centers at Washington State University, and in close collaboration with regional Tribes and Nations. I will have access to state-of-the-art core facilities and laboratory spaces for this work and will be guided by experts in the skills and techniques that I will gain training in. To enrich my research training, I will be attending various workshops, seminar series, and scientific meetings to expand my professional network and prepare me as I transition to an independent scientist. Together, the research and training program developed will enhance the innovative potential of my future research and support my long-term goal of promoting climate resilience and addressing health disparities in vulnerable and underserved populations.

项目摘要 气候变化对传统粮食系统的影响对土著健康非常关注，目前 对怀孕有未知的后果。孕产妇饮食和营养在怀孕方面具有很大影响 结果并可能影响母亲和后代的短期和长期健康。但是，在改变时 气候制度已经记录了对食品可用性和质量的影响，这是有实质性的 对怀孕期间食用食物食物的环境的评价不足。肯定 不良妊娠结局（APO）与孕产妇饮食和营养有关 国家组的APO总体率更高。尽管孕产妇饮食和营养已被确定为 改善健康差异的潜在目标，关于营养的文献很少 土著原住民母亲的怀孕。提出的研究将有助于填补这一关键知识 通过确定气候驱动的环境变化如何影响营养质量来差距 传统食物来源，以及如何决定土著孕产妇的健康结果。我们 使用野生太平洋鲑鱼在怀孕的两个特定目的中进行调查的方法 位于美国太平洋西北部的国家人民，因为太平洋鲑鱼对 环境因素以及该地区的许多土著原住民都在消耗 从远古时代开始，太平洋鲑鱼是至关重要的传统食物。在特定目标1中，我们将建立 太平洋鲑鱼营养含量的气候变化：1）研究营养指标的历史变化 与历史温度有关的博物馆标本； 2）营养的实验验证 通过太平洋鲑鱼暴露于温度升高的变化。在特定目标2中，我们将确定是否 太平洋鲑鱼营养含量通过调查太平洋鲑鱼的消费有助于妊娠结局 在怀孕的原住民个人中，并使用超级学习者（机器学习技术）到：1） 描述太平洋鲑鱼特异性营养对孕妇饮食和 怀孕结果； 2）将开发的模型应用于操纵数据以测试太平洋的变化是否发生变化 鲑鱼特异性营养贡献对饮食会影响妊娠结局。该研究将进行 与华盛顿州立大学的社区保健中心一起，并与地区密切合作 部落和国家。我将可以使用这项工作的最新核心设施和实验室空间， 将由我将获得培训的技能和技巧的专家指导。为了丰富我的研究培训，我 将参加各种研讨会，研讨会系列和科学会议，以扩大我的专业人士 当我过渡到独立科学家时，网络并为我做好准备。一起研究和培训 开发的计划将增强我未来研究的创新潜力，并支持我的长期目标 促进气候弹性并解决脆弱和服务不足的人群中的健康差异。