NeuroMAP Phase II - Recruitment and Assessment Core

NeuroMAP 第二阶段 - 招募和评估核心

• 批准号: 10711136
• 负责人: ROBIN L AUPPERLE
• 金额: $ 33.99万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711136
• 关键词: 2019-nCoV; Acceleration; Accounting; Address; Adult; Affect; Anxiety Disorders; Applications Grants; Arkansas; Behavior; Behavior assessment; Businesses; Cells; Cities; Common Core; Common Data Element; DSM-V; Data; Data Analyses; Data Collection; Databases; Development; Diagnosis; Diagnostic; Disease; Equilibrium; Extramural Activities; Fee-for-Service Plans; Formulation; Future; Goals; Guidelines; Health Sciences; Individual; Infrastructure; Institution; Interoception; Interview; Leadership; Literature; Measures; Mental Health; Mental disorders; Mood Disorders; Moods; Motivation; National Institute of Mental Health; Negative Valence; Neurosciences; Neurosciences Research; Oklahoma; Participant; Patient Recruitments; Patient Self-Report; Performance; Phase; PhenX Toolkit; Physiology; Pilot Projects; Positive Valence; Procedures; Process; Reproducibility; Research; Research Domain Criteria; Research Personnel; Research Project Grants; Research Support; Resources; Severities; Signal Transduction; Standardization; Stimulus; Structure; Symptoms; System; Teenagers; Thinking; Training; United States National Institutes of Health; Universities; Update; Validation; Work; approach behavior; avoidance behavior; base; health assessment; instrument; meetings; motivated behavior; negative affect; novel; operation; recruit; research study; response; screening

PROJECT SUMMARY: Recruitment and Assessment Core Psychiatric research relies on the use of validated and reliable self-report, interview-based, and behavioral assessments to diagnose DSM-5 psychiatric disorders, estimate level of severity of mental health symptoms, and to delineate transdiagnostic constructs of relevance across disorders. The Recruitment and Assessment Core of the Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) in Phase II will support Research Project Leaders (RPLs) and Pilot Project Investigators (PPIs) by overseeing and completing the recruitment, screening, and common Core interview-based, self-report, and behavioral assessment procedures. The goal of the Recruitment and Assessment Core is to accelerate the RPL and PPI projects by allowing for efficient participant recruitment and more rapid data collection, aiding in the formulation of aims and hypotheses based on core data, and thereby making R-level grant applications more competitive. The Recruitment and Assessment Core will work closely with the Circuits and Molecules Core to support a multi-level assessment approach (symptoms & behavior, circuits & physiology, cells & molecules) and is structured to support the NeuroMAP theme: identification and validation, via an experimental approach, of targetable disease-modifying processes (DMPs) in mood and anxiety disorders. During Phase I, common data elements were established across all RPL projects and provided a balance between the research goals of the individual RPL projects and secondary data analyses for PPIs. During this phase, the Core was able to recruit 552 participants for RPLs and each project reached recruitment milestones despite SARS-CoV-2 and a two-month shutdown of the institute. Moreover, 8 PPI used the Core data to identify novel DMPs in mood and anxiety disorders. The Core focuses on measures derived from a modified NIMH Research Domain Criteria approach: (a) Negative Valence Systems measures, i.e., how individuals respond to aversive situations or context (RPL Project 1 focuses on threat sensitivity; Project 2 focuses on avoidance behavior, Project 3 focuses on repetitive negative thinking); (b) Positive Valence Systems measures, i.e., how individuals respond to positive motivational situations or contexts (Project 2 will focus on approach motivation); (c) Interoception measures, i.e. sensing, processing, and integrating internal bodily signals together with external stimuli to affect motivated behavior (Project 2 focuses on responses to interoceptive perturbation). The aims of the core are (1) to provide timely recruitment and standardized assessments for all NeuroMAP projects; (2) to maintain a reproducible and reliable assessment structure that can be used for extramurally supported projects; and (3) to develop a self-sustainable business plan for the user base. The Core will be a unique resource for LIBR investigators as well as researchers at other academic institutions in northeastern Oklahoma and Arkansas.

项目摘要：招聘和评估核心 精神病学研究依赖于使用经过验证和可靠的自我报告、访谈和行为 诊断 DSM-5 精神疾病的评估，估计精神健康症状的严重程度， 并描述跨疾病相关的跨诊断结构。招聘与考核 基于神经科学的心理健康评估和预测中心（NeuroMAP）的核心阶段 II 将通过监督和支持研究项目负责人 (RPL) 和试点项目研究者 (PPI) 完成招聘、筛选和共同核心面试、自我报告和行为 评估程序。招聘和评估核心的目标是加速 RPL 和 PPI 项目通过允许高效的参与者招募和更快速的数据收集来帮助 基于核心数据制定目标和假设，从而使R级资助申请更加容易 竞争的。招募和评估核心将与电路和分子核心密切合作 支持多层次评估方法（症状和行为、回路和生理学、细胞和 分子），其结构支持 NeuroMAP 主题：识别和验证，通过 情绪和焦虑症的有针对性的疾病缓解过程（DMP）的实验方法。 在第一阶段，所有 RPL 项目都建立了通用数据元素，并提供了平衡 各个 RPL 项目的研究目标和 PPI 的二次数据分析之间的关系。在此期间 阶段，核心能够招募 552 名 RPL 参与者，每个项目都达到招募人数 尽管出现 SARS-CoV-2 且该研究所关闭了两个月，但仍取得了里程碑式的进展。此外，8 PPI 使用了 Core 识别情绪和焦虑障碍的新型 DMP 的数据。核心重点关注源自以下方面的措施： 修改后的 NIMH 研究领域标准方法：(a) 负价系统测量，即如何 个人对厌恶的情况或环境做出反应（RPL 项目 1 侧重于威胁敏感性；项目 2 重点关注回避行为，项目3重点关注重复性消极思维）； (b) 正价 系统测量，即个人如何应对积极的动机情况或环境（项目 2 将 关注方法动机）； (c) 内感知措施，即感知、处理和整合内部 身体信号与外部刺激一起影响动机行为（项目 2 侧重于对 内感受扰动）。核心目标是（1）提供及时的招聘和标准化 所有 NeuroMAP 项目的评估； (2) 保持可重复且可靠的评估结构 可用于外部支持的项目； (3) 制定自我可持续的商业计划 用户群。该核心将成为 LIBR 研究人员以及其他研究人员的独特资源 俄克拉荷马州东北部和阿肯色州的学术机构。