Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) Second Bridge Funding Supplement

产生 NIDA 机会的队列合作联盟 (C3PNO) 第二桥资金补充

• 批准号: 10609365
• 负责人: Pamina Mae Gorbach
• 金额: $ 49.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609365
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Area; Automobile Driving; Behavioral; Bioethics; Bioinformatics; Biological Specimen Banks; Biometry; California; Catalogs; Clinical; Clinical Research; Clinical Sciences; Clinical Trials Network; Collaborations; Common Data Element; Computer software; Data; Data Collection; Data Linkages; Data Management Resources; Data Set; Data Sources; Data Store; Databases; Development; Ethics; Foundations; Funding; Gold; HIV; HIV prevention trials network; Immunology; Individual; Industry; Infrastructure; Laboratories; Lead; Leadership; Letters; Link; Logistics; Longitudinal cohort; Los Angeles; Measurement; Measures; Methodology; Methods; Modeling; National Institute of Drug Abuse; Online Systems; Outcome Measure; Participant; Patient Outcomes Assessments; Performance; Procedures; Process; Recording of previous events; Research; Research Personnel; Research Priority; Research Project Grants; Resource Sharing; Resources; Sample Size; Science; Scientist; Site; Specimen; Standardization; Strategic Planning; Study models; Substance abuse problem; System; Technical Expertise; Techniques; Technology; Translating; United States National Institutes of Health; Universities; Work; biobank; bioinformatics network; cohort; comorbidity; data harmonization; data sharing; diverse data; epidemiology study; experience; flexibility; frontier; innovation; instrument; interest; meetings; member; programs; repository; response; substance use; tool; virtual; webinar; working group

ABSTRACT In response to RFA-DA-17-019 we propose to establish a Coordinating Center for the NIDA Cohorts entitled “C3NPO” * to manage and stimulate use of the data generated to address high priority research on HIV/AIDS in the context of substance abuse. Our focus is cutting-edge science powered by the cohorts' combined sample size of approximately 12,500 participants. We bring together a team of researchers with global leadership in substance use, HIV prevention, clinical science and co-morbidities, immunology, modeling, and bioethics to work with NIDA program scientists to stimulate the highest impact science across NIDA-funded cohorts that have compiled unique repositories of varied and rich data. Our proposal uniquely combines academic and professional research management expertise that will stimulate, manage, and support scientific collaboration. We will enable internal and external investigators to cultivate the data from these cohorts in new and innovative scientific directions. Our bioinformatics capacity is uniquely strong in the area of specimen management, having developed the industry gold standard software that will greatly facilitate sharing of specimens across the cohorts. Our leadership bridges NIDA's interests with the perspectives and concerns of the cohorts by having a cohort PI/research scientist (Pamina Gorbach, University of California, Los Angeles) partnered with an experienced HIV network bioinformatics management leader (Suzanne Siminski, Frontier Science & Technology Research Foundation (FSTRF). We will leverage other funded research initiatives though our External Scientific Advisory Board (ESAB) such as NIDA-supported efforts to harmonize measures for substance use research and combine that with data linking strategies. We have the endorsement of all cohort PIs that Consortium leadership is best led from another cohort PI to enhance team science and support for our team as the leaders. The collaborative character of this proposing team offers the potential for new developments in bioinformatics techniques that allow integration of diverse and ever more massive sets of behavioral, clinical, and laboratory data for use by cohort and outside researchers. Thus, our proposal will address NIDA's 2016-2020 Strategic Plan priority focus areas and cross-cutting themes (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan) by leveraging technology, driving innovation, promoting collaboration, and encouraging data and resource sharing. The strategy will develop infrastructure that allows cross-disciplinary, large-scale analyses leading to the highest impact HIV science on substance use.

抽象的 为了响应RFA-DA-17-019 “ C3NPO” * 管理和刺激生成的数据的使用 解决有关艾滋病毒/艾滋病的高优先研究 在滥用毒品的情况下。我们的重点是由同伙组合提供的前沿科学 样本大小约为12,500名参与者。我们将一组研究人员与全球 在药物使用，预防艾滋病毒，临床科学和合并症，免疫学，建模和 与NIDA计划科学家合作的生物伦理学，以刺激NIDA资助的最高影响科学 汇编了各种数据和丰富数据的独特存储库的同类产品。我们的建议独特地结合了 学术和专业研究管理专业知识，将刺激，管理和支持科学 合作。我们将使内部和外部研究人员能够从新的同类中培养这些数据 和创新的科学方向。我们的生物信息学能力在标本领域独特 管理层开发了行业黄金标准软件，该软件将大大促进 横跨人群的标本。我们的领导层以尼达的利益与观点和关注 通过拥有PI/研究科学家（加利福尼亚大学洛杉矶分校的Pamina Gorbach），该队列通过 与经验丰富的HIV网络生物信息学管理领导者（Suzanne Siminski，Frontier）合作 科学技术研究基金会（FSTRF）。我们将利用其他基本研究计划 尽管我们的外部科学咨询委员会（ESAB），例如NIDA支持的努力来协调测量 用于物质使用研究，并将其与数据链接策略相结合。我们得到所有人的认可 联盟领导层最好由另一个队列PI领导，以增强团队科学和支持 对于我们的团队作为领导者。这个提议团队的协作特征为新的潜力提供了潜力 生物信息学技术的发展，允许扩展潜水员和更大的集合 行为，临床和实验室数据，用于同类和外部研究人员。那，我们的建议将 探讨NIDA的2016 - 2020年战略计划优先重点领域和交叉切割主题 （https://www.drugabuse.gov/about-nida/2016-2020-NIDA-Strategic-plan）借用技术，驾驶 创新，促进协作以及鼓励数据和资源共享。策略将发展 允许跨学科大规模分析的基础设施，导致艾滋病毒科学对艾滋病毒的影响最高 使用物质。

项目成果

Changes in secondary substance use after the onset of the COVID-19 pandemic among people who use cannabis: Findings from a web-based sample of adults in the United States.

• DOI: 10.1037/pha0000572
• 发表时间: 2023-04
• 期刊: EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
• 影响因子: 2.3
• 作者: Lake, Stephanie;Assaf, Ryan D.;Gorbach, Pamina M.;Cooper, Ziva D.
• 通讯作者: Cooper, Ziva D.

COVID-19 Testing and the Impact of the Pandemic on the Miami Adult Studies on HIV Cohort.

• DOI: 10.1097/qai.0000000000002680
• 发表时间: 2021-08-01
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Tamargo JA;Martin HR;Diaz-Martinez J;Trepka MJ;Delgado-Enciso I;Johnson A;Mandler RN;Siminski S;Gorbach PM;Baum MK
• 通讯作者: Baum MK

Resilience, Anxiety, Stress, and Substance Use Patterns During COVID-19 Pandemic in the Miami Adult Studies on HIV (MASH) Cohort.

• DOI: 10.1007/s10461-021-03292-y
• 发表时间: 2021-11
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Diaz-Martinez J;Tamargo JA;Delgado-Enciso I;Liu Q;Acuña L;Laverde E;Barbieri MA;Trepka MJ;Campa A;Siminski S;Gorbach PM;Baum MK
• 通讯作者: Baum MK

Stress Increases the Association between Cigarette Smoking and Mental Disorders, as Measured by the COVID-19-Related Worry Scale, in the Miami Adult Studies on HIV (MASH) Cohort during the Pandemic.

• DOI: 10.3390/ijerph19138207
• 发表时间: 2022-07-05
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Diaz-Martinez, Janet;Delgado-Enciso, Ivan;Campa, Adriana;Tamargo, Javier A.;Martin, Haley R.;Johnson, Angelique;Siminski, Suzanne;Gorbach, Pamina M.;Baum, Marianna K.
• 通讯作者: Baum, Marianna K.

Changes in medical and non-medical cannabis use among United States adults before and during the COVID-19 pandemic.

• DOI: 10.1080/00952990.2021.2007257
• 发表时间: 2022-05-04
• 期刊: AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
• 影响因子: 2.7
• 作者: Assaf, Ryan D.;Gorbach, Pamina M.;Cooper, Ziva D.
• 通讯作者: Cooper, Ziva D.