SWG 1 -Translational Research on Substance Use SWG

SWG 1 - 物质使用转化研究 SWG

• 批准号: 10458376
• 负责人: Pamina Mae Gorbach
• 金额: $ 5.19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458376
• 关键词: AIDS prevention; Address; Affect; Area; Assessment tool; Back; Basic Science; Behavior assessment; Behavioral; Cannabinoids; Clinical; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical assessments; Collaborations; Communities; Community Participation; Competence; Consensus; Data; Data Set; Development; Disease; Disease remission; Ecological momentary assessment; Educational workshop; Epidemiology; Exposure to; Faculty; Feedback; Goals; HIV; HIV Infections; Hair; Immune system; Individual; Infection; Intervention; Laboratories; Laboratory Research; Laboratory Scientists; Los Angeles; Mass Spectrum Analysis; Measurement; Measures; Medical; Method Acceptability; Methodology; Methods; Mission; Nail plate; Opioid; Outcome; Paper; Participant; Persons; Pharmaceutical Preparations; Pilot Projects; Prevention; Process; Research; Research Personnel; Sampling; Science; Scientist; Self Administration; Specimen; Stimulant; Translational Research; Translational Research Working Group; Viral; Voice; Work; acceptability and feasibility; analytical method; biobank; care providers; community based participatory research; community engagement; community setting; drug testing; experience; immune reconstitution; implementation barriers; improved; in vivo; innovation; meetings; member; multidisciplinary; novel; research study; substance misuse; substance use; test strip; tool; working group

SWG TRSU: Project Summary/Abstract: The Translational Research on Substance Use (TRSU) Strategic Working Group (SWG) will connect expertise in community engagement with behavioral, basic and clinical scientists across the CFAR cores and broadly across the UCLA and CDU campuses. The TRSU will generate novel and high impact research at the intersection of HIV prevention, treatment and ART-free remission, and substance use/misuse (SU) by examining best practices from the perspective of participants in CFAR activities on how SU data is generated and used. The TRSU moves the field beyond existing approaches for measuring and intervening on substance use/misuse to examine acceptability and implementation challenges at the community level when studying rigorous characterization of SU exposure that can be used to examine impacts on the immune system, and the HIV reservoir. This TRSU will accelerate science in OAR priority areas by emphasizing that cultural relevance and community competency must be assessed for laboratory and behavioral assessments of drug products and SU exposure in individuals relevant to SU and misuse in the context of HIV infection. This will enable scientists working to understand the dynamics of the HIV reservoir in vivo to have better measures of SU, people working on improving rates of viral suppression will be able to obtain validated measures of SU exposure that are acceptable to the community, and those working on HIV prevention will be better able to identify those who can benefit from interventions to address SU disorders with identification of drug products in use. It also will examine how to feedback the findings on drug products and levels of use in local communities from laboratories and scientists in the CFAR to study participants and local care providers. These goals will be achieved by: identifying innovative methods for assessment of SU that can be used in studies of the HIV reservoir and immune reconstitution as well as in epidemiological, basic, and clinical science research to stop HIV. The TRSU will increase access to and stimulate support for multidisciplinary integrated assessments of SU and misuse such as hair sampling, drug product testing by strips/and or mass spectrometry in community settings, and ecological momentary assessments by bringing new investigators from outside HIV into this work. The TRSU will assess community acceptability of methods of assessment of SU most relevant to research on HIV prevention, treatment, and ART-free remission; and enhancing the dissemination of laboratory and clinical assessments of SU among research participants with the development of best practices for community engagement. The TRSU will enhance cultural relevance by engaging community participation in guiding development and use of research tools that can potentially advance intersectional studies of substance use/misuse and the three CFAR themes of HIV Prevention, Treatment and ART-Free Remission.

SWG TRSU：项目摘要/摘要：关于药物使用的转化研究（TRSU）战略 工作组（SWG）将与行为，基本和临床的社区参与方面的专业知识联系起来 CFAR核心的科学家以及在UCLA和CDU校园中广泛的科学家。 TRSU将生成 在艾滋病毒预防，治疗和无艺术缓解的交集中的新颖和高影响研究， 从参与者的CFAR活动的角度检查最佳实践，通过使用药物使用/滥用（SU） 关于如何生成和使用SU数据。 TRSU将田地移动到现有的测量方法之外 并干预药物使用/滥用以检查可接受性和实施挑战 在研究可用于检查影响的SU暴露的严格表征时，社区层面 在免疫系统和艾滋病毒水库上。该TRSU将通过 强调必须对实验室和行为的文化相关性和社区能力进行评估 在HIV背景下，与SU和SU相关的个体中的药品和SU暴露的评估 感染。这将使科学家能够理解体内艾滋病毒水库的动态 更好的SU度量，致力于提高病毒抑制率的人将能够获得经过验证的 社区可以接受的SU暴露措施，而从事艾滋病毒预防的人将是 更好地识别那些可以从干预措施中受益的人通过识别药物来解决SU疾病 使用的产品。它还将研究如何反馈有关毒品产品和本地使用水平的发现 CFAR的实验室和科学家的社区研究参与者和当地护理提供者。这些 将通过以下方式实现目标：确定可用于评估SU的创新方法 艾滋病毒水库和免疫机构以及流行病学，基础和临床科学研究 阻止艾滋病毒。 TRSU将增加对多学科综合评估的访问并刺激支持 SU和滥用诸如头发采样，通过条带/或社区质谱测试的药物产品测试 设置和生态瞬时评估，通过将来自外部艾滋病毒的新调查人员带入这项工作。 TRSU将评估与研究最相关的SU评估方法的社区可接受性 艾滋病毒预防，治疗和无艺术缓解；并增强实验室和临床的传播 通过开发社区最佳实践的研究参与者评估SU的评估 订婚。 TRSU将通过参与社区参与指导来增强文化相关性 开发和使用研究工具，可以潜在地推进物质的交叉研究 使用/滥用以及艾滋病毒预防，治疗和无艺术缓解的三个CFAR主题。