Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)

产生 NIDA 机会的群体合作联盟 (C3PNO)

• 批准号: 10165380
• 负责人: Pamina Mae Gorbach
• 金额: $ 32.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10165380
• 关键词: 2019-nCoV; AIDS prevention; Address; Adherence; Administrative Supplement; Adolescent Medicine Trials Network; Affect; Alcohol or Other Drugs use; Anxiety; Appointment; Area; Baltimore; Behavior; COVID-19; COVID-19 pandemic; Cannabis; Caring; Chicago; Cities; Cohort Studies; Collection; Communities; Continuity of Patient Care; Counseling; Data; Drug usage; Family; Food; Frequencies; Funding; Funding Opportunities; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV prevention trials network; Health; Height; Home environment; Housing; Individual; Infrastructure; Injections; Interruption; Link; Los Angeles; Measures; Medical Records; Mental Health; Methamphetamine; NIH Program Announcements; National Institute of Drug Abuse; North America; Opioid; Participant; Patient Self-Report; Pharmaceutical Preparations; Population; Population Group; Prevalence; Prevention; Research; Risk Factors; Science; Smoking; Social isolation; Specific qualifier value; Substance Use Disorder; Surveys; Time; Tobacco; Vulnerable Populations; addiction; antiretroviral therapy; base; cohort; data harmonization; design; experience; food insecurity; frontier; high risk; innovation; interest; intimate partner violence; marijuana vaping; neurodevelopment; novel; opioid use disorder; pre-exposure prophylaxis; prescription opioid; public health emergency; response; social; stimulant use; vaping; young men who have sex with men

ABSTRACT In response to the Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (Notice Number NOT-DA-20-047 and linked Program Announcement PA-18-591) funding opportunity, the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO; U24DA044554) proposes a project to assess the impact of COVID-19 on the participating cohorts' population of substance-using people living with HIV (PLWH) and those at high-risk for HIV infection. Our innovative study proposes to collect data from a subset of participants from each of seven participating C3PNO cohorts at two time points – in the height of the COVID-19 pandemic and during its mitigation and control – in order to assess the impact of the COVID-19 epidemic on substance use for PLWH and those at high risk for HIV. We will use our current infrastructure and C3PNO validated harmonization strategies to compile new and existing data across the cohorts in order to: assess changes in social and individual determinants of health during the course of the COVID-19 pandemic, to estimate differences in substance-using behaviors of those who were confirmed/probable cases of COVID-19 (based on self-report or medical record) and those who were not a confirmed/probable case, and to assess how PLWH and people who are at high risk for HIV in C3PNO have different experiences in and responses to the COVID-19 epidemic as compared to other HIV studies and cohorts that have less substance use. The C3PNO Coordinating Center at UCLA and Frontier Science will facilitate the design and implementation of a survey to collect data from a subset of participants from each of seven participating C3PNO cohorts (ALIVE, HYM, JHHCC, MASH, mSTUDY, RADAR, and V-DUS). Participating cohorts will issue the survey to participants and transfer the resulting data to the coordinating center. If funded, this administrative supplement would allow a rapid and coordinated collection of linked COVID-19, HIV, and substance use data related to an ongoing public health emergency affecting the highly vulnerable substance-using populations followed by the cohorts. COVID-19 data harmonization with other HIV cohorts will further aide our collective effort to understand the impact of COVID-19 on HIV impacted communities. Finally, C3PNO's effort to assess changes in social and individual determinants of health during the course of the COVID-19 pandemic as well as estimate differences in substance-using behaviors and the impact on PLWH or at high risk for HIV is both novel and critical in this time of unprecedented social upheaval and instability.

抽象的 响应有关行政补品可用性的特殊利益通知（NOSI）和 紧急竞争修订2019年小说冠状病毒（通知号非DA-DA-20-047）的竞争性修订 和链接的计划公告PA-18-591）资助机会，合作联盟 生产NIDA机会（C3PNO; U24DA044554）提出了一个评估Covid-19的影响的项目 在参与的人群中，使用艾滋病毒（PLWH）和高风险的人群 用于HIV感染。我们的创新研究建议，旨在从七个参与者的一部分中收集数据 参与两个时间点的C3PNO队列 - 在Covid-19大流行期间及其期间 缓解和控制 - 为了评估Covid-19-19的影响对PLWH的物质使用的影响 以及患有艾滋病毒的高风险的人。我们将使用当前的基础架构和C3PNO验证的协调 为了以下策略编译新数据和现有数据以： 在COVID-19-19大流行期间，健康决定者的个人决定者，以估计 被确认/可能的COVID案例的人的物质行为（基于自我报告或 病历）和那些不是确认/可能的情况的人，并评估PLWH和人如何 在C3PNO中，HIV的高风险具有不同的经验和对Covid-19的流行的反应 与其他艾滋病毒研究和同类群体相比，使用较少的物质使用。 C3PNO协调中心 UCLA和Frontier Science将促进调查的设计和实施，以从子集中收集数据 来自七个参与C3PNO队列的参与者（Alive，Hym，JHHCC，MASH，Mstudy， 雷达和v-dus）。参与的队列将向参与者发出调查并传输结果数据 到协调的中心。如果资助，这种行政补充将允许快速和协调 链接的COVID-19，HIV和药物使用数据的收集与正在进行的公共卫生紧急情况有关 影响高度脆弱的物质种群，其次是人群。 COVID-19数据 与其他艾滋病毒队列的协调将进一步促进我们的集体努力，以了解Covid-19的影响 关于艾滋病毒受影响的社区。最后，C3PNO评估社会和个人决定者的变化的努力 在Covid-19大流行过程中的健康状况以及使用物质的估计差异 在这个史无前例的时代 社会动荡和不稳定。