Mentorship in patient-oriented research to optimize community-based HIV prevention for adults at high-risk of HIV at alcohol drinking venues in East Africa

指导以患者为导向的研究，以优化东非饮酒场所艾滋病毒高危成年人的社区艾滋病毒预防

• 批准号: 10762303
• 负责人: Gabriel Chamie
• 金额: $ 19.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762303
• 关键词: 2019-nCoV; AIDS prevention; Address; Adherence; Adult; Africa; Africa South of the Sahara; African; Alcohol abuse; Alcohol consumption; Alcohols; Attention; Award; Awareness; California; Caring; Clinic; Clinical Trials; Collaborations; Communicable Diseases; Communities; Community Trial; Consumption; Counseling; Country; Educational workshop; Effectiveness; Facility Accesses; Faculty; Future; Goals; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; HIV/TB; Health Personnel; Health care facility; Hot Spot; Human immunodeficiency virus test; Incidence; Infrastructure; Intervention; Interview; Kenya; Measures; Medical; Medical Research; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Perception; Persons; Physicians; Play; Population; Prevalence; Prevention; Prevention Research; Prevention approach; Prophylactic treatment; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Institute; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Rural; San Francisco; Services; Site; Surveys; Time; Training; Transact; Uganda; Universities; Unsafe Sex; Viral; Work; alcohol misuse; arm; career; career development; community intervention; community setting; cost; drinking; experience; female sex worker; health care availability; high risk; human centered design; implementation framework; implementation outcomes; improved; innovation; interest; intervention delivery; member; mid-career faculty; novel; outreach; patient oriented; patient oriented research; person centered; pilot test; pilot trial; postdoctoral investigator; pre-doctoral; pre-exposure prophylaxis; preference; prevention effectiveness; prevention service; preventive intervention; primary outcome; programs; prototype; recruit; service delivery; sex; social stigma; testing services; therapy development; transmission process; treatment services; uptake

Project Summary Dr. Gabriel Chamie is an infectious diseases physician and Associate Professor of Medicine in the Division of HIV, Infectious Diseases and Global Medicine at the University of California, San Francisco (UCSF). His research has focused on developing effective approaches to promote community-based diagnosis of HIV, TB and SARS-CoV-2, and engagement in HIV and TB prevention and treatment, with a more recent focus on persons with unhealthy alcohol use in East Africa. He has over a decade of experience mentoring numerous early-stage investigators (ESI), including pre- and post-doctoral investigators and junior faculty, and now seeks the protected time of a K24 award to focus greater attention and time on mentoring, mentorship training and expanding his research program at the intersection of HIV and alcohol use. In this application, Dr. Chamie proposes a comprehensive mentorship, mid-career development, and research plan to address the challenge of reaching and engaging populations at increased risk of HIV in biomedical HIV prevention from alcohol drinking venues in East Africa. Despite a growing number of efficacious biomedical HIV prevention options, a major challenge remains reaching persons at highest risk of HIV – such as adults at alcohol drinking venues – who do not routinely engage in medical care, to overcome barriers to HIV prevention initiation and retention, including alcohol use. To further develop and expand his patient-oriented research (POR) program and mentoring, he proposes mid-career training in methods that support the application of quantitative preference elicitation and human-centered design for intervention development, and additional training in mentorship. Leveraging the infrastructure of his recently awarded R01 (the OPAL trial) and the ongoing SEARCH- SAPPHIRE trial, Dr. Chamie proposes research in this application to: a) elicit preferences for biomedical HIV prevention service delivery among adults at high risk of HIV who attend drinking venues in rural Kenya and Uganda, b) to adapt the SAPPHIRE trial’s clinic-based “dynamic PrEP/PEP choice” intervention for community- based delivery to this population at or near drinking venues, and c) to assess uptake, retention, and adherence to biomedical prevention in a pilot trial of community-based biomedical prevention delivery among adults who attend or work at drinking venues in rural Kenya and Uganda. With the guidance of an experienced senior mentorship team, Dr. Chamie will utilize multiple ongoing research projects, and long-standing research collaborations between UCSF and Makerere University in Uganda and the Kenya Medical Research Institute in Kenya, to provide mentees with a robust infrastructure on which to develop their research interests and support US-East African ESI partnerships in POR. The K24 award is instrumental to supporting him in achieving his long-term goals of becoming a global leader in HIV and alcohol use research and mentoring future leaders in patient-oriented research from the US and East Africa.

项目摘要 Gabriel Chamie博士是一种感染性疾病，医学和医学副教授 旧金山分校（UCSF）的艾滋病毒，传染病和全球医学。他的 研究的重点是开发有效的方法来促进基于社区的艾滋病毒诊断，结核病 以及SARS-COV-2，以及参与HIV和TB的预防和治疗，最新的重点是 东非有不健康饮酒的人。他多次有十年的经验心态 早期调查人员（ESI），包括博士后研究员和初级教师，现在寻求 K24奖的受保护时间，以将更多的关注和时间放在心理，精神训练和时间上 在艾滋病毒和饮酒的交集中扩大了他的研究计划。在此申请中，Chamie博士 提出全面的心态，职业中期发展和研究计划，以应对挑战 在生物医学艾滋病毒预防饮酒中，艾滋病毒风险增加和吸引人的人口 东非的饮酒场所。尽管有越来越多的有效的生物医学预防艾滋病毒选择，但 主要的挑战仍然存在于最高风险的艾滋病毒风险的人（例如饮酒场所的成年人） 谁不常规从事医疗服务，以克服预防艾滋病毒的障碍和保留的障碍， 包括饮酒。进一步开发和扩大其面向患者的研究（POR）计划和 他指导，他提出了支持定量偏好应用的方法中职业培训 启发和以人为中心的设计进行干预开发，并在心态方面进行额外的培训。 利用他最近授予R01（蛋白石审判）和正在进行的搜索的基础设施 - 蓝宝石试验，Chamie博士在此应用中研究的研究：a）引起生物医学艾滋病毒的偏好 艾滋病毒高风险的成年人的预防服务交付，他们参加了肯尼亚农村和 乌干达，b）适应蓝宝石试验的基于诊所的“动态准备/PEP选择”干预措施 - 基于向该人群或附近的饮酒场所交付，c）评估摄取，保留和依从性 在针对基于社区的生物医学预防交付的成年人的试验试验中进行生物医学预防 在肯尼亚和乌干达的饮酒场所参加或工作。在经验丰富的高年级的指导下 Menorship Team，Chamie博士将利用多个正在进行的研究项目和长期研究 UCSF与乌干达的Makerere大学与肯尼亚医学研究所之间的合作 肯尼亚，为门德提供强大的基础设施，以发展其研究兴趣和支持 POR的美国东非ESI合作伙伴关系。 K24奖有助于支持他实现自己的 成为艾滋病毒和酒精使用研究的全球领导者的长期目标 美国和东非的以患者为导向的研究。