MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE)

加州大学洛杉矶分校的 MSM 和物质队列将感染注意影响联系起来（男性）

• 批准号: 8850993
• 负责人: Pamina Mae Gorbach
• 金额: $ 0.9万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8850993
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Advisory Committees; Affect; Age; Alcohol or Other Drugs use; Amphetamines; Anti-Retroviral Agents; Anus; Archives; Basic Science; Behavior; Behavioral; Biological; Biological Testing; Biopsy; Blood; CD4 Positive T Lymphocytes; California; Caring; Chlamydia; Cohort Studies; Communicable Diseases; Communities; County; Crack Cocaine; Data; Drug usage; Drug user; Epidemic; Epidemiology; Fostering; Gonorrhea; HIV; HIV Infections; HIV Seropositivity; HIV risk; HIV therapy; HIV-1; HIV/STD; Health; Health Insurance Portability and Accountability Act; Hepatitis C; Hepatitis C virus; Heroin; High Prevalence; Hispanics; Immune; Immunology; Improve Access; Incidence; Individual; Infection; Inflammatory; Inflammatory Response; Injecting drug user; Knowledge; Lead; Link; Liquid substance; Los Angeles; Measurable; Methamphetamine; Minority; Mucositis; Mucous Membrane; National Institute of Allergy and Infectious Disease; National Institute of Drug Abuse; Pathogenesis; Pattern; Pharmaceutical Preparations; Plasma; Population; Predisposition; Prevalence; Prevention; Public Health; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk; Risk Behaviors; Sampling; Science; Sexual Transmission; Sexually Transmitted Diseases; Source; Specimen; Substance abuse problem; Syphilis; Tissues; Treatment Protocols; Universities; Viral Load result; Visit; Work; base; biobank; clinically relevant; cohort; comparative; cytokine; ecstasy; high risk; immune function; innovation; mathematical model; medication compliance; member; men who have sex with men; non-drug; novel; rectal; repository; response; sexually active; transmission process; treatment adherence

DESCRIPTION (provided by applicant): This application in response to NIDA PAR 12-222 Cohort Studies of HIV/AIDS and Substance Use (U01) seeks to leverage extensive existing infrastructure and cohorts at the University of California, Los Angeles to launch a new cohort of substance using minority (Black or Hispanic) men who have sex with men (MMSM). The epidemic of HIV among MMSM in the US and locally in Los Angeles County (LAC) may be driven by effects of substance use on adherence to treatment regimens and bio-behavioral prevention and enhanced by high prevalence networks. Proposed investigators lead the science on studying associations between non-injection drug use, risk behaviors and infectious disease among MSM, and contribute a broad portfolio of inter-disciplinary work from immunology and basic science to epidemiology, prevention and treatment. The work proposed leverages existing cohorts including the Multicenter AIDS Cohort (MACS) and existing repositories and builds on preliminary work to guide assembly of a cohort for the study of basic and behavioral factors in younger MMSM who actively use substances and engage transmission risks. Establishing a cohort of young active substance users, particularly stimulant users, who have poor histories of antiretroviral treatment (ART) adherence as marked by measurable and clinically relevant Plasma Viral Load (PVL) will enable important tests of biological influences of substances on immune function in MMSM. This cohort is central to prevention and treatment efforts and will provide well-characterized, extensive repository samples for leveraged use with other cohorts, networks' and individual's studies. The MMSM will be: (i) HIV-positive with viral load >5000 copies/ml or (ii) HIV-negative at high risk for HIV infection (unprotected anal intercourse in the past 6 months). This unique cohort will facilitate studies on interactions between substance use and HIV progression and/or transmission, which are of critical public health significance. This cohort of MMSM will characterize: (i) effects substance use on behavioral and network level risk in exposed and infected MMSM on acquisition of HIV and other sexually transmitted infections (STIs: gonorrhea, Chlamydia, syphilis, Hepatitis C (HCV)); and (ii) the extent to which substance use in MMSM facilitates behaviors that transmit HIV compared to non-drug using MMSM. The application also proposes to develop and maintain a bio repository that is HIPAA-compliant, technologically-current and DAIDS Network interfaced that includes a scientific advisory committee. This cohort will comprise 620 MMSM with repeated data visits (from 1,080 MMSM). At least half of these MMSM will be active substance users and younger than age 30.

描述（由申请人提供）：本申请响应NIDA PAR 12-222对HIV/AIDS和药物使用的队列研究（U01）旨在利用洛杉矶大学加利福尼亚大学的广泛现有基础设施和队列，以推出一种新的使用少数民族（黑人或西班牙裔男性）的药物（MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMS）的药物。美国MMSM和洛杉矶县（LAC）的艾滋病毒流行可能是由物质使用对治疗方案和生物行为预防的依从性的影响所驱动的，并通过高流行网络增强。拟议的研究人员领导科学研究MSM之间非注射药物使用，风险行为和传染病之间的关联，并贡献了从免疫学和基础科学到流行病学，预防和治疗的广泛跨学科工作组合。这项工作提出的利用了现有的队列，包括多中心艾滋病队列（MAC）和现有的存储库，并以初步工作为基础，以指导组装同类群体，以研究年轻MMSM的基本和行为因素，这些MMSM的基本和行为因素积极使用物质并参与传播风险。建立一群年轻的活性药物使用者，尤其是兴奋的使用者，他们的抗逆转录病毒治疗历史较差（ART）依从性以可测量和临床相关的血浆病毒载量（PVL）为标志，将启动对MMSM中免疫功能的生物学影响的重要测试。该队列对于预防和治疗工作至关重要，将提供良好的，广泛的存储库样品，用于与其他同类，网络和个人研究的杠杆使用。 MMSM将为：（i）病毒载荷> 5000份/mL或（ii）HIV阴性的HIV阳性，HIV感染高风险（过去6个月中未受保护的肛门性交）。这种独特的队列将促进有关物质使用与艾滋病毒进展和/或传播之间相互作用的研究，这是至关重要的公共健康意义。 MMSM的这一组将表征：（i）在暴露和感染MMSM中对物质使用对艾滋病毒和其他性传播感染的收购的影响（STIS：Gonorrhea，gonorrhea，syphilis，syphilis，syphilis，Hepatitis c（HCV））; （ii）MMSM中物质使用的程度促进了与使用MMSM相比的非药物相比，传播HIV的行为。该应用程序还建议开发和维护一个符合HIPAA的生物存储库，该存储库包括科学咨询委员会，该网络连接到包括科学咨询委员会。该队列将包含620 mmmsm的重复数据访问（从1,080 mmmsm）。这些MMSM中至少有一半是活跃的药物使用者，并且年龄在30岁以下。