Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN)Scientific Leadership Center; ADMIN SUPPLEMENT

艾滋病毒/艾滋病干预青少年医学试验网络 (ATN) 科学领导中心；

• 批准号: 10855435
• 负责人: Lisa B Hightow-Weidman
• 金额: $ 195.49万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-05 至 2029-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10855435
• 关键词: AIDS prevention; Achievement; Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Adolescence; Adolescent; Adolescent Medicine Trials Network; Adolescent and Young Adult; Age; Alcohol consumption; Area; Award; Budgets; Caring; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Complex; Consultations; Continuity of Patient Care; Development; Dissemination and Implementation; Elements; Emotional; Enrollment; Ensure; Epidemic; Evolution; Friends; Funding; Goals; Growth; HIV; HIV Infections; HIV Seronegativity; HIV prevention trials network; HIV/AIDS; HIV/STD; Individual; Infection; Infrastructure; Intervention; Leadership; Mental Health; Mission; Monitor; Neurocognitive; Oils; Ownership; Parents; Pharmaceutical Preparations; Phase; Population; Poverty; Prevalence; Prevention; Productivity; Protocols documentation; Qualifying; Research; Research Priority; Research Support; Resources; Science; Site; Social Change; Structure; Substance abuse problem; System; Talents; United States; United States National Institutes of Health; Violence; Viral; Vision; Work; Youth; adolescent HIV prevention; adolescent health outcomes; age group; career; clinical research site; community-level factor; cost; design; electronic consent; evidence base; experience; improved; innovation; insight; medical appointment; member; multidisciplinary; operation; participant retention; participant safety; pharmacovigilance; pre-exposure prophylaxis; programs; racism; recruit; resilience; social media; social stigma; uptake; web site; young adult

The scientific rationale for this supplement is to support the Adolescent Medicine Trials Network for HIV Interventions (ATN) mission and overall aims. These supplemental funds are needed to cover unanticipated costs that were not budgeted in either the original Scientific Leadership Center (SLC) application (RFA-HD-23- 020) or the Operations and Collaborations Center (OCC) application (RFA-HD-23-021) but are critical to the successful execution of the ATN goals. All funds requested support core needs and gaps identified through collaborative consultation with members of the SLC, OCC and NIH and are for activities that are within the scope of the originally reviewed and awarded application. Based on our detailed review of the parent RFAs, we anticipated that all of these activities would have been included in the application put forth by the OCC. However, now that the network has launched, we have found that these critical gaps exist and re-budgeting from the prime award to cover these costs is not an option because all the awarded funds are obligated. Specific Aim 1: Advance a rigorous and innovative research agenda to end the HIV epidemic among adolescents and young adults (ages 13-24) in the US by establishing a robust ATN infrastructure that prioritizes and implements high-impact research. The administrative supplement will support research gaps in current ATN agenda, specifically addressing HIV prevention and care needs among youth impacted by alcohol use and aligning one of the currently supported protocols with a collaborative protocol in the HIV Prevention Trials Network (HPTN). Further, the supplement supports important aspects of successful research implementation, including enrollment and retention of participants through social media and eConsent and critical aspects of monitoring participant safety and pharmacovigilance. Specific Aim 2: Facilitate internal communication and external collaborations and idea exchange to optimize alignment with NIH priorities, address emergent opportunities and maximize network productivity and resources. The administrative supplement will support successful implementation and dissemination of ATN protocols. While the OCC is developing the ATN website, they do not have the capacity or expertise to create any recruitment/dissemination materials to be displayed on the website nor have they planned for any dissemination activities at the site level. Specific Aim 3: Develop and nurture partnerships that will ensure community and youth input at all stages of conceptualization, design, implementation, and interpretation of the research. The administrative supplement will support adequate representation of youth within the ATN. The Subject Matter Research Consultants (SMRC) are a core facet of the ATN and are being deeply embedded into all aspects of the project including as members of protocol teams, scientific leadership groups, and Communication and Dissemination Hub where they will provide ongoing consultation.

该补充的科学原理是支持艾滋病毒的青少年医学试验网络 干预措施（ATN）任务和整体目标。需要这些补充资金来涵盖意外的 最初的科学领导中心（SLC）应用程序（RFA-HD-23--- 020）或操作与协作中心（OCC）应用程序（RFA-HD-23-021），但对 成功执行ATN目标。所有资金都要求支持核心需求和差距 与SLC，OCC和NIH成员的合作咨询，并用于活动中的活动 最初审查和授予申请的范围。根据我们对父rfas的详细评论，我们 预计所有这些活动都将包括在OCC提出的申请中。 但是，既然该网络已经启动，我们发现存在这些关键差距并重新预算 从Prime奖励到支付这些费用不是一个选择，因为所有奖励资金都有义务。 特定目的1：提出严格而创新的研究议程，以结束艾滋病毒的流行 在美国，青少年和年轻人（13-24岁）通过建立强大的ATN基础设施 优先考虑并实施高影响力的研究。行政补充将支持研究 当前ATN议程的差距，专门针对受艾滋病毒的预防和护理需求。 饮酒并与艾滋病毒中的协作协议对当前支持的协议之一对齐 预防试验网络（HPTN）。此外，这些补充剂支持成功研究的重要方面 实施，包括通过社交媒体和Econsent的参与者入学和保留参与者以及 监测参与者安全和药物措施的关键方面。特定目标2：促进内部 沟通和外部协作和想法交流，以优化与NIH的一致性 优先级，解决新兴机会并最大程度地提高网络生产率和资源。这 行政补充将支持成功实施和传播ATN协议。尽管 OCC正在开发ATN网站，他们没有能力或专业知识来创建任何 将在网站上展示的招聘/传播材料，也没有计划 现场级别的传播活动。特定目标3：建立和培育合作伙伴关系，以确保 社区和青年在概念化，设计，实施的各个阶段的投入和 研究的解释。行政补充剂将支持足够的青年代表 在ATN中。主题研究顾问（SMRC）是ATN的核心方面 深层嵌入项目的各个方面，包括作为协议团队的成员，科学领导 小组以及沟通和传播中心将提供持续的咨询。