Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Scientific Leadership Center

艾滋病毒/艾滋病干预青少年医学试验网络 (ATN) 科学领导中心

• 批准号: 10595899
• 负责人: Lisa B Hightow-Weidman
• 金额: $ 1116.21万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-25 至 2029-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595899
• 关键词: AIDS prevention; Achievement; Acquired Immunodeficiency Syndrome; Address; Adolescence; Adolescent; Adolescent Medicine Trials Network; Adolescent and Young Adult; Age; Area; Caring; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Complex; Continuity of Patient Care; Development; Elements; Emotional; Ensure; Epidemic; Evolution; Friends; Goals; Growth; HIV; HIV Infections; HIV Seronegativity; HIV/AIDS; HIV/STD; Individual; Infection; Infrastructure; Intervention; Leadership; Mental Health; Mission; Neurocognitive; Oils; Ownership; Pharmaceutical Preparations; Phase; Population; Poverty; Prevalence; Prevention; Productivity; Qualifying; Research; Research Priority; Resources; Science; Social Change; Structure; Substance abuse problem; System; Talents; United States; United States National Institutes of Health; Violence; Viral; Vision; Work; Youth; adolescent HIV prevention; adolescent health outcomes; age group; career; clinical research site; community-level factor; design; evidence base; experience; improved; innovation; insight; medical appointment; multidisciplinary; operation; pre-exposure prophylaxis; programs; racism; resilience; social stigma; uptake; young adult

Adolescents and young adults (AYA) under the age of 25 in the United States (US) are the least likely of all age groups to: 1) know their HIV status, 2) initiate PrEP if HIV-negative even when indicated, 3) take medication as prescribed, attend medical appointments, and be virally suppressed if living with HIV. Persistent rates of new infections among US youth indicate that evidence-based and integrated approaches to increase the uptake and use of effective biomedical prevention and treatment products are required. Adolescence and young adulthood are challenging developmental periods, with significant physical, neurocognitive, emotional, and social changes. While multiple vulnerabilities and complex community factors drive the HIV epidemic among youth, these developmental periods are also characterized by opportunities for growth, achievement, and resilience. HIV research networks must be broad in agenda, go beyond traditional clinical sites and individual level interventions and address the multi-faceted, multi-level barriers that have thwarted HIV prevention and care progress among AYA. The newly envisioned Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) is a multi- component collaborative research enterprise focused on the reduction of new HIV infections among AYA in the US as well as improvements across the HIV continuum of care for youth living with HIV. Such a large-scale, complex clinical research program demands high productivity and strong contributions from each essential component. Our proposed overall network structure is conceptualized as a well-oiled machine with interdependent structures working together seamlessly to achieve the mission of the ATN. The Scientific Leadership Center (SLC) will bring all elements together and ensure that they function collaboratively, effectively, and efficiently with the Operations and Collaboration Center (OCC), NIH, and the overall network. The ATN has identified five high priority research areas to address the substantial and disproportionate gaps in the health outcomes of AYA across the HIV prevention and care continuum. With this application, we include seven highly innovative and impactful clinical trials led by talented multi-disciplinary teams, addressing all five priority research areas, spanning key populations of youth, multiple socioecological systems, and a variety of regulatory phases. We are also poised to accept emerging research opportunities as the field of prevention and treatment science advances. Communities will be situated at the center of the ATN’s work because community ownership, engagement, and connectedness are critical for successful research implementation. Drs. Hightow-Weidman and Hosek are uniquely qualified as MPIs to lead the SLC. Both have worked in the field of adolescent HIV prevention and treatment for the entirety of their careers and have worked collaboratively within the ATN for >16 years, giving them clear insight on how best to make this new iteration successful. Our overall vision for a redesigned and robust ATN is one that not only anticipates and plans for ongoing evolution in the HIV field and an emerging scientific agenda but one with a renewed focus on the most impactful science and priority areas.

在美国25岁以下的青少年和年轻人（AYA）（美国）是所有年龄段的最小可能 组：1）知道其HIV状况，2）如果艾滋病毒阴性，即使指示了艾滋病毒阴性，3）服用药物为 开处方，参加医疗预约，如果艾滋病毒居住，几乎被抑制了。持续的新率 我们年轻人中的感染表明，基于证据和综合的方法来增加吸收和 需要使用有效的生物医学预防和治疗产品。青少年和成年 受到挑战的发展时期，具有重大的身体，神经认知，情感和社会变化。 尽管多种脆弱性和复杂的社区因素驱动了青年人的艾滋病毒流行，但 艾滋病病毒 研究网络必须在阿格恩达（Agernda）广泛，超越了传统的临床站点和个人水平干预措施 并解决具有阻碍艾滋病毒预防和护理进步的多方面的多面障碍 嗯。新设想的艾滋病毒/艾滋病干预措施（ATN）的青少年医学试验网络是多种多样的 组件协作研究企业的重点是减少AYA中新的HIV感染 我们以及在艾滋病毒青年的艾滋病毒连续体中的改善。如此大规模， 复杂的临床研究计划需要每个基本的生产率高和强大的贡献 成分。我们提出的整体网络结构被概念化为一台用良好的机器 相互依存的结构无缝地共同努力，以实现ATN的使命。科学 领导力中心（SLC）将将所有要素汇集在一起​​，并确保它们有效，有效地运作， 并有效地利用了运营与协作中心（OCC），NIH和整个网络。 ATN有 确定了五个高优先研究领域，以解决健康方面的巨大和不成比例的差距 AYA在HIV预防和护理连续体中的结果。使用此应用程序，我们将七个高度包括在内 由才华横溢的多学科团队领导的创新且有影响力的临床试验，解决所有五项优先研究 领域，涵盖青年的关键人群，多个社会生态系统以及各种监管阶段。 我们也被毒死，接受新兴的研究机会作为预防和治疗科学领域 进步。社区将位于ATN工作的中心，因为社区所有权， 参与和联系对于成功的研究实施至关重要。博士。 Hightow-Weidman Hosek和Hosek成为MPI的独特资格，以领导SLC。两者都在青春期艾滋病毒领域工作 整个职业的预防和治疗 多年来，让他们清楚地了解如何最好地使这种新的迭代成功。我们对 重新设计和健壮的ATN不仅预期并计划在艾滋病毒领域进行持续发展，并且 一个新兴的科学阿格恩达，但人们重新关注最有影响力的科学和优先领域。