The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core - Methods

迈阿密大学艾滋病心理健康和艾滋病毒/艾滋病研究中心 - Center for HIV

• 批准号: 10686544
• 负责人: Daniel J Feaster
• 金额: $ 47.48万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686544
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Affect; Applications Grants; Architecture; Area; Award; Behavioral; Biological Markers; Biometry; Caring; Cities; Clinical Treatment; Clinical Trials Network; Collaborations; Common Data Element; Communities; Complement; Complex; Consent; Consultations; Cost Effectiveness Analysis; Data; Databases; Development; Disparity; Doctor of Philosophy; Drug abuse; Drug usage; Economic Models; Educational workshop; Epidemic; Ethics; Evidence based practice; Extramural Activities; Funding; Geographic Information Systems; Geographic Locations; Geography; Goals; Growth; HIV; HIV/AIDS; Haitian; Health Resources; Healthcare Systems; Heterogeneity; Implant; Individual; Inflammation; Infrastructure; Injectable; Interdisciplinary Study; International; Intervention; Language; Libraries; Machine Learning; Maps; Measurement; Measures; Mental Health; Methodology; Methods; Modality; Modeling; Modernization; Molecular Neurobiology; National Institute of Drug Abuse; Nature; Neighborhoods; Outcome; Population; Prevention; Process; Psychometrics; Psychosocial Assessment and Care; Qualitative Methods; Qualitative Research; Reproducibility; Research; Research Design; Research Personnel; Research Support; Resource Sharing; Resources; Science; Services; Statistical Data Interpretation; Statistical Methods; Strategic Planning; Stress; Subgroup; Substance abuse problem; Techniques; Technology; Training; Triage; Universities; Validity and Reliability; Viral Load result; Visualization; Work; biobehavior; community engaged research; community engagement; comorbidity; cost effectiveness; data management; data repository; data warehouse; design; eHealth; health assessment; health data; health disparity; health economics; health goals; innovation; instrument; intersectionality; mHealth; meetings; minority health disparity; multilevel analysis; outcome disparities; programs; relational database; social; social culture; social structure; success; synergism; therapy development; treatment effect

PROJECT SUMMARY: METHODS CORE (C) Building off our success as a Core in the D-ARC, in this transition to a Full ARC, we will expand upon our services and training in statistical analysis techniques, research design, qualitative approaches, mental health (MH) measurement, and data management. Because of CHARM’s theme related to reducing the impact of MH and minority health disparities across the HIV prevention and care continua, we focus on multi-level methods. MH comorbidities are inherently individual-level processes. In contrast, MH and minority health disparities are driven by higher-level structural socio-cultural processes that exist at the various levels (e.g., neighborhoods, cities, regions) within which individuals are nested. Therefore, interventions and approaches of Center investigators are likely to address both individual and socio-cultural processes and, thus, be multi-level. The Methods Core is responsible for promotion of state-of-the-science research design (statistical methods and qualitative approaches) via consultation in multi-level research that will inform local implementation of evidence-based practice consistent with CHARM goals. Activities to address this aim include providing consultation to MH-HIV researchers developing grant proposals (as well as post-award support) and supporting early-stage investigators with CHARM Developmental Core Awards Program studies in the areas of research design, use of biomarkers of HIV and its comorbidities, and analytic strategies. To optimize resource-sharing and collaboration on MH-HIV research among CHARM investigators, the Methods Core will expand a unified data architecture, centralized data repository, and collaborate across cores on an instrument library. The voluntary unified data architecture includes common data elements to facilitate collaboration and cooperative projects to utilize CHARM data in ways not possible in single studies. The Core also maintains databases for both consent-to-contact databases implemented by the Mental Health Disparities and Community Engagement Core and the CHARM REDCap Measures Library of well-established validated instruments; including Spanish and Haitian Creole-language measures of constructs relevant to HIV and MH. Finally, the Methods Core provides triaged access to CHARM resources, state-of-the-science methodology workshops, and other capacity-building activities focused on addressing MH disparities in HIV. Via the CHARM Research Navigation Portal, investigators and community partners are provided coordinated access to all CHARM resources, methodology consultations, and methods-focused workshops with content on machine learning, reproducibility, multilevel modelling, geographically-focused analysis, intersectionality, reliability and validity across populations, and model selection approaches. The Core also facilitates consultations and presentations from other CHARM Cores and affiliated research groups, such as the CFAR, CTSI, NIDA’s National Drug Abuse Treatment Clinical Trials Network, and NIDA’s P30 CHERISH Center, which focuses on cost-effectiveness analysis.

项目摘要：方法核心（C） 在D-Arc的核心中建立成功，在过渡到完整的弧线中，我们将扩展我们的 统计分析技术，研究设计，定性方法，心理健康的服务和培训 （MH）测量和数据管理。由于魅力的主题与减少MH的影响有关 以及整个HIV预防和关怀连续性的少数族裔健康差异，我们专注于多层次方法。 MH合并症本质上是个人级别的过程。相反，MH和少数族裔健康差异是 受不同层次存在的高层结构社会文化过程的驱动（例如，社区， 城市，区域），其中嵌套了个人。因此，中心的干预和方法 研究人员可能会解决个人和社会文化过程，因此是多层的。 方法核心负责促进科学研究设计（统计 方法和定性方法）通过在多层研究中进行咨询，该研究将为当地提供信息 实施与魅力目标一致的循证实践。解决此目标的活动包括 向MH-HIV研究人员提供咨询 通过魅力发展的早期调查员在 研究设计，艾滋病毒及其合并症生物标志物的使用以及分析策略。 为了优化有关魅力研究者MH-HIV研究的资源共享和协作， 方法核心将扩展统一的数据架构，集中数据存储库，并在跨核心上进行协作 在乐器库上。自愿统一的数据架构包括促进的通用数据元素 在单一研究中，协作和教练项目以无法使用魅力数据。核心 还维护数据库，用于由心理健康差异实施的两个同意联系数据库 和社区参与核心和魅力RedCap衡量已建立验证的库 乐器；包括与艾滋病毒和MH相关的西班牙和海地克里奥尔语语言措施。 最后，方法核心提供了对魅力资源的分类访问权限，最先进的 方法论研讨会和其他能力建设活动的重点是解决艾滋病毒中的MH差异。 通过魅力研究导航门户网站，调查人员和社区合作伙伴将协调 访问所有魅力资源，方法论咨询和以内容为中心的方法的讲习班 机器学习，可重复性，多级建模，以地理为中心的分析，交叉性， 人群之间的可靠性和有效性以及模型选择方法。核心也有助于 其他魅力核心和会员研究小组（例如CFAR）的咨询和演讲， CTSI，NIDA的国家药物滥用治疗临床试验网络和NIDA的P30珍贵中心， 侧重于成本效益分析。