Research Core Methods

研究核心方法

• 批准号: 10361449
• 负责人: Daniel J Feaster
• 金额: $ 23.66万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-22 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10361449
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Applications Grants; Architecture; Area; Award; Behavioral; Biological Markers; Caring; Cities; Clinical Treatment; Clinical Trials Network; Collaborations; Common Data Element; Complement; Complex; Consultations; Cost Effectiveness Analysis; Data; Data Collection; Development; Disease; Doctor of Philosophy; Drug abuse; Educational workshop; Evidence based practice; Extramural Activities; Funding; Goals; Guidelines; HIV; Haitian; Heterogeneity; Individual; Instruction; Intervention; Language; Libraries; Machine Learning; Measurement; Measures; Mental Health; Methodology; Methods; Modeling; Modernization; National Institute of Drug Abuse; Nature; Neighborhoods; Outcome; Pilot Projects; Process; Psychosocial Assessment and Care; Research; Research Design; Research Methodology; Research Personnel; Research Project Summaries; Research Support; Resources; Science; Services; Statistical Data Interpretation; Statistical Methods; Subgroup; System; Techniques; Training; Triage; United States National Institutes of Health; Universities; University resources; Work; base; behavioral outcome; biobehavior; comorbidity; cost effectiveness; data management; data repository; design; electronic data; health disparity; implementation cost; implementation intervention; implementation research; implementation science; implementation study; innovation; instrument; minority health disparity; multilevel analysis; ranpirnase; social; social culture; social structure; synergism; therapy development; treatment effect

Project Summary Research Methods Core C The Methods Core will provide services and training in statistical analysis techniques, research design, mental health (MH) measurement, and data management. With the University of Miami Developmental AIDS Research Center (UM D-ARC)’s emphasis on Reducing the Impact of Mental Health and Minority Health Disparities across the HIV Prevention and Care Continua we focus on multi-level methods. MH co- morbidities are inherently individual-level processes. In contrast, MH and minority health disparities are driven by higher-level structural socio-cultural processes that exist at the various levels (e.g. neighborhoods, cities, regions) within which the individual is nested. Therefore, interventions and approaches of center investigators are likely to address both individuals as well as these socio-cultural processes and, thus, be multi-level. The Methods Core has three aims. Aim 1: To promote use of appropriate state-of-the-science research design and statistical methods in multi-level research that will inform local implementation of evidence-based practice consistent with the UM D-ARC theme and goals. Activities to address this aim will include providing consultation to HIV/AIDS MH researchers developing NIH grant proposals (as well as post-award support) and supporting early stage investigator with UM-ARC pilot studies in the areas of research design, use of biomarkers of HIV and its comorbidities, and statistical analysis strategies. Aim 2: To create, maintain, and facilitate use of a centralized data repository and an instrument library as resources for high-impact research on MH and minority health disparities in HIV/AIDS. This will include a voluntary unified data architecture that includes common data elements to facilitate collaboration and cooperative projects to utilize D-ARC data in innovative new ways and a REDCap instrument library including Spanish and Haitian Creole-language measures. We will provide access to existing electronic data collection forms and instruction on how to create new electronic data collection forms for new measures. Aim 3: To provide triaged access to other UM D-ARC Core resources as well as state-of-the science methodology workshops and other capacity-building activities that complement and expand existing UM resources to focus on MH disparities in HIV/AIDS. Activities to support this aim include creation of a comprehensive Research Navigation Platform to coordinate access to D-ARC methodology consultations and all Center resources; and conducting new methods-focused workshops with content on multilevel modeling, GIS mapping of MH outcomes, methods for identifying subgroups and estimating treatment effect heterogeneity, approaches to implementation research, and model selection approaches. The Core will also facilitate consultations and presentations from other D-ARC cores and affiliated research groups, such as the CFAR, CTSI, NIDA’s National Drug Abuse Treatment Clinical Trials Network, and NIDA’s P30 CHERISH Center, which focuses on cost-effectiveness analysis.

项目概要 研究方法 Core C 方法核心将提供统计分析技术、研究设计、心理分析等方面的服务和培训。 健康（MH）测量和数据管理与迈阿密大学发展艾滋病。 研究中心 (UM D-ARC) 强调减少心理健康和少数民族健康的影响 艾滋病毒预防和护理方面的差异 我们继续关注多层次的 MH 方法。 发病本质上是个人层面的过程，相比之下，MH 和少数族裔的健康差异是由其驱动的。 通过存在于各个层面（例如社区、城市、 区域），因此，中心研究人员的干预措施和方法。 可能既涉及个人也涉及这些社会文化进程，因此是多层次的。 核心方法有三个目标 1：促进使用适当的最新科学技术。 多层次研究中的研究设计和统计方法将为当地实施 与 UM D-ARC 主题和目标相一致的基于证据的实践，以实现这一目标。 将包括向艾滋病毒/艾滋病 MH 研究人员提供咨询，制定 NIH 拨款提案（以及 授予后支持）并支持早期研究人员在研究领域进行 UM-ARC 试点研究 设计、使用 HIV 及其合并症的生物标志物以及统计分析策略。 维护并促进使用集中式数据存储库和仪器库作为资源 关于艾滋病毒/艾滋病方面的 MH 和少数族裔健康差异的高影响力研究 这将包括一项自愿研究。 统一数据架构，包括通用数据元素以促进协作和合作 项目以创新的新方式利用 D-ARC 数据和 REDCap 仪器库，包括西班牙语和 我们将提供对现有电子数据收集表格和海地克里奥尔语措施的访问。 关于如何为新措施创建新电子数据收集表格的说明： 提供新措施。 对其他 UM D-ARC 核心资源以及最新科学方法的访问进行分类 补充和扩展现有 UM 资源的研讨会和其他能力建设活动 关注艾滋病毒/艾滋病方面的 MH 差异。支持这一目标的活动包括建立一个全面的机制。 研究导航平台，用于协调 D-ARC 方法咨询和所有中心的访问 资源；并举办以新方法为重点的研讨会，内容涉及多层次建模、GIS 制图 MH 结果、识别亚组和估计治疗效果异质性的方法、方法 核心还将促进咨询和模型选择方法。 其他 D-ARC 核心和附属研究小组（例如 CFR、CTSI、NIDA）的演讲 国家药物滥用治疗临床试验网络和 NIDA 的 P30 CHERISH 中心，该中心专注于 成本效益分析。