CTN-0121: Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders among Hospitalized Patients

CTN-0121：住院患者严重传染病和药物滥用障碍的综合护理和治疗

• 批准号: 10442205
• 负责人: Daniel J Feaster
• 金额: $ 121.33万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10442205
• 关键词: Address; Adolescent; Adult; Area; Budgets; Caring; Childhood; Clinic; Clinical Research; Cocaine; Collaborations; Communicable Diseases; Data; Data Science; Dissemination and Implementation; Electronic Health Record; Epidemic; Evidence based treatment; Family; Florida; Foundations; HIV; HIV/HCV; Harm Reduction; Health system; Healthcare; Healthcare Systems; Hispanics; Hospitals; Information Systems; Infrastructure; Injecting drug user; Intervention; Leadership; Learning; Mainstreaming; Medical; Mental Health; Methamphetamine; Methods; Modeling; National Institute of Drug Abuse; Opioid; Overdose; Patients; Pharmaceutical Preparations; Population; Precision therapeutics; Prevention; Primary Health Care; Puerto Rico; Registries; Research; Schools; Science; Substance Use Disorder; Technology; Testing; Training; Treatment outcome; Universities; Work; base; behavioral health; bioinformatics tool; comorbidity; design; eHealth; experience; follow-up; health care settings; health economics; implementation science; improved; individual response; innovation; patient population; point of care; practice-based research network; precision medicine; protocol development; screening; service delivery; stimulant use; substance use; success; treatment response; treatment services; Address; Adolescent; Adult; Area; Budgets; Caring; Childhood; Clinic; Clinical Research; Cocaine; Collaborations; Communicable Diseases; Data; Data Science; Dissemination and Implementation; Electronic Health Record; Epidemic; Evidence based treatment; Family; Florida; Foundations; HIV; HIV/HCV; Harm Reduction; Health system; Healthcare; Healthcare Systems; Hispanics; Hospitals; Information Systems; Infrastructure; Injecting drug user; Intervention; Leadership; Learning; Mainstreaming; Medical; Mental Health; Methamphetamine; Methods; Modeling; National Institute of Drug Abuse; Opioid; Overdose; Patients; Pharmaceutical Preparations; Population; Precision therapeutics; Prevention; Primary Health Care; Puerto Rico; Registries; Research; Schools; Science; Substance Use Disorder; Technology; Testing; Training; Treatment outcome; Universities; Work; base; behavioral health; bioinformatics tool; comorbidity; design; eHealth; experience; follow-up; health care settings; health economics; implementation science; improved; individual response; innovation; patient population; point of care; practice-based research network; precision medicine; protocol development; screening; service delivery; stimulant use; substance use; success; treatment response; treatment services

PROJECT SUMMARY/ABSTRACT This is an application for years 21-25 of NIDA’s CTN Florida Node Alliance (FNA). The FNA covers Florida, Georgia and Puerto Rico, areas of the US that continue to suffer from high rates of drug overdoses and unceasing opioid, cocaine and methamphetamine epidemics. These areas have unmet treatment needs and experience disparities in the implementation of evidence-based treatments. The FNA aims to build on our record of success in leading and implementing trials in healthcare settings and integrating substance use into mainstream of healthcare. We propose to bring to the CTN the FNA’s considerable expertise in adolescent treatment, the HIV and HCV care continua in substance-using populations, mental health comorbidities, e- Health, data science, culturalized science, health economics, training, implementation/dissemination, and work with Hispanic populations. The FNA’s research agenda will provide scientific leadership to develop, test, and implement interventions for the full spectrum of substance use in adolescents and adults, and strategies for the integration of SU prevention/screening/treatment services into mainstream adolescent and adult health care. The FNA also aims to apply our expertise in implementation science, data science, and use of electronic health records (EHRs) to promote learning health care systems that build on precision medicine principles by implementing and refining methods to predict individual response to treatment. Building on a foundation of bidirectional collaboration, the FNA proposes to develop, test and implement interventions that address the service delivery continuum in the FNA’s clinical and research networks. These networks consist of SUD treatment and general medical settings, health systems, clinical research networks, and practice-based research networks. To achieve its aims, the FNA is proposing an innovative research agenda of concepts that (1) integrate behavioral health and family focused interventions in pediatric care with the use of e-technologies, (2) deliver integrative models of care for comorbid SU and HIV in hospital settings, (3) address the comorbidities of mental health and stimulant use, (4) use EHR, registry and environmental data to improve treatment precision, and (5) use context and culture to improve treatment outcomes. The FNA proposes to collaborate with other Nodes on the design and implementation of CTN trials and by providing the infrastructure and capabilities required for successful study execution. FNA network partners have demonstrated experience in conducting point of care trials and studies that leverage the use of EHR and claims data. The University of Miami CTSI, University of Florida CTSI, and the Georgia CTSA, will bring to the CTN the bioinformatics tools of the CTSA National Consortium. These CTSAs together with partners of the FNA, facilitate access to a diverse patient population of 16+ million patients across a numerous settings such as primary care, EDs, hospitals, FQHCs, school-based clinics, SUD treatment and harm reduction venues.

项目摘要/摘要 这是NIDA CTN佛罗里达节点联盟（FNA）21 - 25年的应用。 FNA覆盖佛罗里达， 佐治亚州和波多黎各，美国地区的药物过量发生率很高， 不断的阿片类药物，可卡因和甲基苯丙胺发作。这些领域有未满足的治疗需求， 在实施基于证据的治疗方面经历差异。 FNA旨在以我们的 领导和实施医疗保健设置中的试验的成功记录，并将物质使用整合到 医疗保健的主流。我们建议将FNA在青少年的巨大专业知识带入CTN 治疗，艾滋病毒和HCV护理连续性在使用物质的人群中，心理健康合并症，E- 健康，数据科学，文化科学，健康经济学，培训，实施/传播以及工作 与西班牙裔人口。 FNA的研究议程将为发展，测试和 在青少年和成年人中实施各种物质使用范围的干预措施，并采取策略 将SU预防/筛查/治疗服务整合到主流青少年和成人医疗保健中。 FNA还旨在将我们的专业知识应用于实施科学，数据科学和电子健康的使用 记录（EHRS）促进以精确医学原则为基础的学习医疗保健系统 实施和完善方法以预测个人对治疗的反应。建立在基础上 双向协作，FNA的提案，开发，测试和实施干预措施，以解决 在FNA的临床和研究网络中，服务提供继续。这些网络由SUD组成 治疗和一般医疗环境，卫生系统，临床研究网络和基于实践的 研究网络。为了实现其目标，FNA提出了创新的研究议程 （1）使用电子技术的综合行为健康和家庭关注的小儿护理干预措施， （2）在医院环境中为合并症和艾滋病毒提供综合护理模型，（3）解决 心理健康和兴奋性使用的合并症，（4）使用EHR，注册表和环境数据来改进 治疗精度和（5）使用上下文和文化来改善治疗结果。 FNA提案 与其他节点在CTN试验的设计和实施方面合作，并通过提供 成功的研究执行所需的基础架构和能力。 FNA网络合作伙伴有 在执行护理试验和研究中表现出的经验，这些经验利用了EHR的使用和 索赔数据。迈阿密大学CTSI大学，佛罗里达大学CTSI和佐治亚州CTSA将带给 CTN CTSA国家财团的生物信息学工具。这些CTSA与 FNA，促进在多种环境中获得16+百万患者的潜水员患者的机会 作为初级保健，EDS，医院，FQHC，学校诊所，SUD治疗和减少伤害场所。