Research Core Methods

研究核心方法

基本信息

批准号：
10115852
负责人：
Daniel J Feaster
金额：
$ 32.21万
依托单位：
UNIVERSITY OF MIAMI CORAL GABLES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-22 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10115852
关键词：
AIDS prevention AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Applications Grants Architecture Area Award Behavioral Biological Markers Caring Cities Clinical Treatment Clinical Trials Network Collaborations Common Data Element Complement Complex Consultations Cost Effectiveness Analysis Data Data Collection Development Disease Doctor of Philosophy Drug abuse Educational workshop Evidence based practice Extramural Activities Funding Goals Guidelines HIV Haitian Heterogeneity Individual Instruction Intervention Language Libraries Machine Learning Measurement Measures Mental Health Methodology Methods Modeling Modernization National Institute of Drug Abuse Nature Neighborhoods Outcome Pilot Projects Process Psychosocial Assessment and Care Research Research Design Research Methodology Research Personnel Research Project Summaries Research Support Resources Science Services Statistical Data Interpretation Statistical Methods Structure Subgroup System Techniques Training Triage United States National Institutes of Health Universities University resources Work base behavioral outcome biobehavior comorbidity cost effectiveness data management data repository design electronic data health disparity implementation cost implementation intervention implementation research implementation science implementation study innovation instrument minority health multilevel analysis ranpirnase social social culture social structure synergism therapy development treatment effect

AIDS prevention AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Applications Grants Architecture Area Award Behavioral Biological Markers Caring Cities Clinical Treatment Clinical Trials Network Collaborations Common Data Element Complement Complex Consultations Cost Effectiveness Analysis Data Data Collection Development Disease Doctor of Philosophy Drug abuse Educational workshop Evidence based practice Extramural Activities Funding Goals Guidelines HIV Haitian Heterogeneity Individual Instruction Intervention Language Libraries Machine Learning Measurement Measures Mental Health Methodology Methods Modeling Modernization National Institute of Drug Abuse Nature Neighborhoods Outcome Pilot Projects Process Psychosocial Assessment and Care Research Research Design Research Methodology Research Personnel Research Project Summaries Research Support Resources Science Services Statistical Data Interpretation Statistical Methods Structure Subgroup System Techniques Training Triage United States National Institutes of Health Universities University resources Work base behavioral outcome biobehavior comorbidity cost effectiveness data management data repository design electronic data health disparity implementation cost implementation intervention implementation research implementation science implementation study innovation instrument minority health multilevel analysis ranpirnase social social culture social structure synergism therapy development treatment effect

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项目摘要

Project Summary Research Methods Core C The Methods Core will provide services and training in statistical analysis techniques, research design, mental health (MH) measurement, and data management. With the University of Miami Developmental AIDS Research Center (UM D-ARC)’s emphasis on Reducing the Impact of Mental Health and Minority Health Disparities across the HIV Prevention and Care Continua we focus on multi-level methods. MH co- morbidities are inherently individual-level processes. In contrast, MH and minority health disparities are driven by higher-level structural socio-cultural processes that exist at the various levels (e.g. neighborhoods, cities, regions) within which the individual is nested. Therefore, interventions and approaches of center investigators are likely to address both individuals as well as these socio-cultural processes and, thus, be multi-level. The Methods Core has three aims. Aim 1: To promote use of appropriate state-of-the-science research design and statistical methods in multi-level research that will inform local implementation of evidence-based practice consistent with the UM D-ARC theme and goals. Activities to address this aim will include providing consultation to HIV/AIDS MH researchers developing NIH grant proposals (as well as post-award support) and supporting early stage investigator with UM-ARC pilot studies in the areas of research design, use of biomarkers of HIV and its comorbidities, and statistical analysis strategies. Aim 2: To create, maintain, and facilitate use of a centralized data repository and an instrument library as resources for high-impact research on MH and minority health disparities in HIV/AIDS. This will include a voluntary unified data architecture that includes common data elements to facilitate collaboration and cooperative projects to utilize D-ARC data in innovative new ways and a REDCap instrument library including Spanish and Haitian Creole-language measures. We will provide access to existing electronic data collection forms and instruction on how to create new electronic data collection forms for new measures. Aim 3: To provide triaged access to other UM D-ARC Core resources as well as state-of-the science methodology workshops and other capacity-building activities that complement and expand existing UM resources to focus on MH disparities in HIV/AIDS. Activities to support this aim include creation of a comprehensive Research Navigation Platform to coordinate access to D-ARC methodology consultations and all Center resources; and conducting new methods-focused workshops with content on multilevel modeling, GIS mapping of MH outcomes, methods for identifying subgroups and estimating treatment effect heterogeneity, approaches to implementation research, and model selection approaches. The Core will also facilitate consultations and presentations from other D-ARC cores and affiliated research groups, such as the CFAR, CTSI, NIDA’s National Drug Abuse Treatment Clinical Trials Network, and NIDA’s P30 CHERISH Center, which focuses on cost-effectiveness analysis.

项目摘要研究方法核心C 方法核心将在统计分析技术，研究设计，心理方面提供服务和培训健康（MH）测量和数据管理。与迈阿密大学发展艾滋病研究中心（UM D-ARC）强调减少心理健康和少数民族健康的影响艾滋病毒预防和护理连续性的差异我们专注于多层次方法。 MH共同病态是固有的个人级过程。相反，MH和少数族裔健康差异是驱动的通过在各个层面上存在的高层结构社会文化过程（例如社区，城市，区域）中嵌套的区域。因此，中心调查人员的干预和方法可能会解决个人以及这些社会文化过程，因此是多层次的。方法核心具有三个目标。目标1：促进使用适当的水平多层次研究中的研究设计和统计方法将为本地实施提供信息循证实践与UM D-ARC主题和目标一致。解决这个目标的活动将包括向艾滋病毒/艾滋病的MH研究人员提供咨询雄辩后的支持）并在研究领域为早期阶段调查员提供了UM-ARC试点研究设计，艾滋病毒生物标志物及其合并症的使用以及统计分析策略。目标2：创建，维护并促进使用集中式数据存储库和仪器库作为资源对艾滋病毒/艾滋病中MH和少数族裔健康差异的高影响研究。这将包括自愿统一的数据体系结构，其中包括通用数据元素，以促进协作和合作以创新的新方式使用D-ARC数据的项目以及包括西班牙语和包括西班牙语的RedCap仪器库海地克里奥尔语语言测量。我们将提供对现有电子数据收集表的访问权限和有关如何为新测量创建新的电子数据收集表格的说明。目标3：提供访问其他UM D-ARC核心资源以及最先进的科学方法论讲习班和其他能力建设活动，这些活动完成和扩大现有的UM资源专注于艾滋病毒/艾滋病的MH差异。支持此目标的活动包括创建全面研究导航平台，以协调访问D-ARC方法论和所有中心资源;并进行新方法的研讨会，其中包含有关多层建模的内容，GIS映射 MH结果，识别亚组的方法和估计治疗效果异质性的方法实施研究和模型选择方法。核心还将促进咨询和来自其他D-ARC核心和会员研究小组的演讲，例如CFAR，CTSI，NIDA 国家药物滥用治疗临床试验网络和NIDA的P30珍贵中心，重点介绍成本效益分析。