The Florida Node Alliance of the National Drug Abuse Treatment Clinical Trials Network

国家药物滥用治疗临床试验网络佛罗里达节点联盟

• 批准号: 10655864
• 负责人: Daniel J Feaster
• 金额: $ 197.03万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10655864
• 关键词: Address; Adolescent; Adult; Budgets; Caring; Childhood; Clinic; Clinical Research; Clinical Treatment; Clinical Trials Network; Collaborations; Data; Data Science; Development; Dissemination and Implementation; Drug abuse; Electronic Health Record; Family; Florida; Foundations; HIV; HIV/HCV; Harm Reduction; Health system; Healthcare; Healthcare Systems; Hispanic Populations; Hospitals; Infrastructure; Injecting drug user; Intervention; Leadership; Learning; Mainstreaming; Manuals; Medical; Mental Health; Methods; Modeling; Patients; Population; Precision therapeutics; Prevention; Primary Health Care; Procedures; Ramp; Registries; Research; Schools; Science; Site; Technology; Testing; Training; Treatment outcome; Universities; Work; base; behavioral health; bioinformatics tool; comorbidity; design; eHealth; experience; follow-up; health care settings; health economics; implementation science; improved; individual response; innovation; patient population; point of care; practice-based research network; precision medicine; screening; service delivery; stimulant use; substance use; success; treatment response; treatment services

PROJECT SUMMARY/ABSTRACT The Florida Node Alliance (FNA) aims to build on our record of success in leading and implementing trials in healthcare settings and integrating substance use into mainstream of healthcare. We propose to bring to the CTN the FNA’s considerable expertise in adolescent treatment, the HIV and HCV care continua in substance- using populations, mental health comorbidities, e-Health, data science, culturalized science, health economics, training, implementation/dissemination, and work with Hispanic populations. The FNA’s research agenda will provide scientific leadership to develop, test, and implement interventions for the full spectrum of substance use in adolescents and adults, and strategies for the integration of SU prevention/screening/treatment services into mainstream adolescent and adult health care. The FNA also aims to apply our expertise in implementation science, data science, and the use of electronic health records (EHRs) to promote learning health care systems that build on precision medicine principles by implementing and refining methods to predict individual response to treatment. Building on a foundation of bidirectional collaboration, the FNA proposes to develop, test, and implement interventions that address the service delivery continuum in the FNA’s clinical and research networks. These networks consist of SUD treatment and general medical settings, health systems, clinical research networks, and practice-based research networks. To achieve its aims, the FNA is proposing an innovative research agenda of concepts that (1) integrate behavioral health and family-focused interventions in pediatric care with the use of e-technologies, (2) deliver integrative models of care for comorbid SU and HIV in hospital settings, (3) address the comorbidities of mental health and stimulant use, (4) use EHR, registry and environmental data to improve treatment precision, and (5) use context and culture to improve treatment outcomes. The FNA proposes to collaborate with other Nodes on the design and implementation of CTN trials and by providing the infrastructure and capabilities required for successful study execution. FNA network partners have demonstrated experience in conducting point of care trials and studies that leverage the use of EHR and claims data. The University of Miami CTSI, University of Florida CTSI, and the Georgia CTSA will bring to the CTN the bioinformatics tools of the CTSA National Consortium. These CTSAs together with partners of the FNA, facilitate access to a diverse patient population of 16+ million patients across numerous settings such as primary care, EDs, hospitals, FQHCs, school-based clinics, SUD treatment, and harm reduction venues.

项目摘要/摘要 佛罗里达节点联盟（FNA）旨在基于我们在领导和实施试验中成功的记录。 医疗保健环境和将物质使用整合到医疗保健的主流中。我们建议将 CTN FNA在青少年治疗方面具有丰富的专业知识，HIV和HCV护理在物质中继续进行 - 使用人群，心理健康合并症，电子健康，数据科学，文化科学，健康经济学， 培训，实施/传播以及与西班牙裔人群合作。 FNA的研究议程将 提供科学领导来开发，测试和实施各种物质的干预措施 在青少年和成年人中使用，以及用于整合SU预防/筛查/治疗服务的策略 进入主流青少年和成人医疗保健。 FNA还旨在将我们的专业知识应用于实施 科学，数据科学以及电子健康记录（EHR）的使用来促进学习医疗保健 通过实施和完善方法来预测个人的系统，以精确的医学原理为基础 对治疗的反应。 FNA提出的提案以双向合作为基础 测试和实施干预措施，以解决FNA临床中的服务交付连续性和 研究网络。这些网络包括SUD治疗和一般医疗环境，卫生系统， 临床研究网络和基于实践的研究网络。为了实现其目标，FNA提出了 （1）综合行为健康和以家庭为中心的创新研究议程 小儿护理的干预措施使用电子技术，（2）为合并症提供集成的护理模型 SU和HIV在医院环境中，（3）解决心理健康和兴奋剂使用的合并症，（4）使用EHR， 注册表和环境数据提高治疗精度，（5）使用上下文和文化来改善 治疗结果。 FNA的建议与其他节点合作就设计和实施 CTN试验并通过提供成功的研究执行所需的基础架构和能力。 FNA 网络合作伙伴已经证明了在进行护理点试验和研究方面的经验 使用EHR和索赔数据。迈阿密大学CTSI大学，佛罗里达大学CTSI和佐治亚州CTSA 将为CTN带来CTSA国家财团的生物信息学工具。这些CTSA和 FNA的合作伙伴，促进了众多16多名患者的潜水员患者的机会 诸如初级保健，EDS，医院，FQHC，学校诊所，SUD治疗和伤害等设置 还原场所。